Exploring the links between idea generation and motivation

The adoption of specific idea management programs is becoming a strategic asset for organizations as they are increasingly trying to adopt specific organizational solutions to detect, fertilize, evaluate and promote new idea generation within and across their boundaries. The centrality of ideas generation is linked to its vital characteristic of being the main source for new products, services, processes, and drivers of change. This papers deals with the controversial role of general organizational setting and closely focuses on the rewards mechanisms that can further nurture creativity. We submit that understanding of the motivational drivers as well as acknowledging the importance of the organizational settings for individual learning behavior and idea generation is crucial in order to distill the links between idea generation and incentive structures. Consistently, we will conduct a theoretical understanding of the phenomenon in order to explain how new ideas can be nurtured through the adoption of a routine system aligned with general human resource management policy

New Idea Generation and Individual Motivation: A conceptual framework

The adoption of specific idea management programs is becoming a strategic asset for organizations as they are increasingly trying to adopt specific organizational solutions to detect, fertilize, evaluate and promote new idea generation within and across their boundaries. The centrality of the ideas generation is linked to its vital characteristic of being the main source for new products, services, processes, and drivers of change. This papers copes with the controversial role of the general organizational setting and closely focuses on the rewards mechanisms that could further nurture creativity. By formulating a set of propositions, the paper submits that the understanding of the motivational drivers and the organizational settings is paramount to distill the links between idea generation and incentive structures. This paper aims also to critically analyze and assess the impact of extrinsic and intrinsic motivation on idea generation both at an individual and team level, and develop a framework within which explore the necessary change to be adopted by firms in managing the idea generation. What is new to the field is the recognition of the impact of the individual locus of control on creative performance. In this vein the paper sees its ultimate aim in uncovering the dynamics of individual and collective motivation related to creativity, considered as the main source for innovation. The paper concludes that new ideas could be nurtured through the adoption of routine system aligned with the companies human resource management policy

Determinants of early working impairments in multiple sclerosis

IntroductionUnemployment can directly affect social status and identity. Assessing and adjusting determinants of early working impairments in a chronic disease can thus reduce its long-term burden. Hereby, we aim to evaluate differences in occupational history and early working impairments between people with multiple sclerosis (MS) and healthy workers.MethodsThis is a cross-sectional study comparing 71 workers with MS [age 41.7 ± 9.4 years; females 59.1%; EDSS 2.0 (1.0–6.0)] and 71 controls (age 42.6 ± 11.9 years; females 33.8%). All participants filled in Work Ability Index (WAI), Work Productivity and Activity Impairment (WPAI), European Questionnaire for Quality of Life (EuroQoL), Beck Depression Inventory II (BDI-II), and Pittsburgh Sleep Quality Index (PSQI). In MS, we further collected expanded disability status scale (EDSS), MS Questionnaire for Job difficulties (MSQ-Job), Fatigue severity scale (FSS), and the Brief International Cognitive Assessment for MS (BICAMS).ResultsWorkers with MS were more working disabled (p < 0.01), less exposed to workplace risks (p < 0.01), and more limited in fitness to work (p = 0.01), compared with controls. On linear regression models adjusted by age, sex, education, and type of contract, people with MS had worse WAI (Coeff=−5.47; 95% CI = −7.41, −3.53; p < 0.01), EuroQoL (Coeff = −4.24; 95% CI = −17.85, −6.50; p < 0.01), BDI-II (Coeff = 3.99; 95% CI = 2.37, 7.01; p < 0.01), and PSQI (Coeff = 4.74; 95% CI = 3.13, 7.61; p < 0.01), compared with controls, but no differences in WPAI (p = 0.60). EuroQoL, BDI-II, and PSQI were equally associated with both WAI and WPAI in MS and controls (all p< 0.01). In MS, worse MSQJob was associated with higher EDSS (Coeff = 5.22; 95% CI = 2.24, 7.95; p < 0.01), progressive disease (Coeff = 14.62; 95% CI = 5.56, 23.69; p < 0.01), EuroQoL (Coeff = 4.63; 95% CI = 2.92, 6.35; p < 0.01), FSS (Coeff = 0.55; 95% CI = 0.38, 0.72; p < 0.01), and cognitive impairment (Coeff = 4.42; 95% CI = 0.67, 8.22; p = 0.02).DiscussionEarly factors associated with working difficulties in MS include disability, fatigue, depression, and cognitive dysfunction. Early identification of clinical features potentially causing working difficulties should be considered to enhance job retention, along with targeted prevention and protection measures

Framing offshoring: Antecedents, processes, and outcomes

Following the increasing globalization of value chains, offshoring is gaining importance for firms' competitiveness. Strategy, management, and organizational scholars have analyzed this phenomenon from different theoretical lenses and with a variety of methodological approaches. However, literature lacks a framework within which to analyze firms' offshoring strategies and processes. This paper proposes an interpretative framework to understand extant literature as well as to identify possible gaps to be fulfilled with future research. The identified categories of the proposed interpretative framework are: antecedents, processes, and outcomes. We use case-based evidence to populate the framework and to highlight implications for innovation management. \uc2\ua9 2013 World Scientific Publishing Company

ARGONAUTE1 and ARGONAUTE4 regulate gene expression and hypoxia tolerance

In plants, hypoxia can be induced by submergence and the lack of oxygen impairs mitochondrial respiration, thus affecting the plant's energy status. Hypoxia has major effects on gene expression; these changes induce key responses that help meet the needs of the stressed plant. However, little is known about the possible role of RNA signaling in the regulation of gene expression under limited oxygen availability. Here, we report the contribution of ARGONAUTE1 (AGO1) to hypoxia-induced gene regulation in Arabidopsis (Arabidopsis thaliana). Submergence induced changes in levels of the microRNAs miR2936 and miR398 but this had no obvious effects on their putative target mRNA levels. However, we found that ago1-27 plants are intolerant to submergence and transcriptome analysis identified genes whose regulation requires functional AGO1. Analysis of mutants affected in various branches of RNA signaling highlighted the convergence of AGO1 signaling with the AGO4-dependent RNA-directed DNA methylation (RdDM) pathway. AGO4-dependent RdDM represses the expression of HOMOLOG OF RPW8 4 (HR4) and alters its response to submergence. Remarkably, methylation of the second exon of HR4 is not only reduced in ago4-1 but also in plants overexpressing a constitutively stable version of the oxygen sensor RELATED TO AP2 12 (RAP2.12), indicating convergence of oxygen signaling with epigenetic regulation of gene expression. Therefore, our results identify a role for AGO1 and AGO4 RNA-silencing pathways in low-oxygen signaling in Arabidopsis

Comparison of transplastomic Chlamydomonas reinhardtii and Nicotiana tabacum expression system for the production of a bacterial endoglucanase

The bulk production of recombinant enzymes by either prokaryotic or eukaryotic organisms might contribute to replace environmentally non-friendly chemistry-based industrial processes with enzyme-based biocatalysis, provided the cost of enzyme production is low. In this context, it is worth noting that the production of recombinant proteins by photosynthetic organisms offer both eukaryotic (nuclear) and prokaryotic (chloroplast) alternatives, along with the advantage of an autotrophic nutrition. Compared to nuclear transformation, chloroplast transformation generally allows a higher level of accumulation of the recombinant protein of interest. Furthermore, among the photosynthetic organisms, there is a choice of using either multicellular or unicellular ones. Tobacco, being a non-food and non-feed plant, has been considered as a good choice for producing enzymes with applications in technical industry, using a transplastomic approach. Also unicellular green algae, in particular Chlamydomonas reinhardtii, have been proposed as candidate organisms for the production of recombinant proteins. In the light of the different features of these two transplastomic systems, we decided to make a direct comparison of the efficiency of production of a bacterial endoglucanase. With respect to the amount obtained, 14 mg g-1 of biomass fresh weight equivalent to 8-10% of the total protein content, and estimated production cost, 1.5-2 € Kg-1, tobacco proved to be far more favourable for bulk enzyme production when compared to Chlamydomonas reinhardtii which accumulated this endoglucanase at 0.003% of the total protein