9 research outputs found

    P53 expression.

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    <p>A, B, C and D: invasive cervical cancer epithelium. (A) negative; (B) less than 5% nuclear stain positivity; (C) 5% to 25% nuclear stain positivity; (D) higher than 25% (FastRed, red stain; Mag 40×, Fig A Mag.20×).</p

    Clinical performance of p16<sup>INK4a</sup>, Ki-67 and p53 immunostaining in relationship to FIGO stage III or more severe (FIGO III+) and FIGO II+.

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    <p>Se = sensitivity, Sp = specificity, YI = Youden's Index (Sp+Se−100%).</p>*<p>Highlighted with bold font are the cut point combinations of p16<sup>INK4a</sup> and Ki-67 that are most accurate (highest Youden's Index) for consensus diagnosis of FIGO II+.</p

    P16<sup>ink4a</sup> expression.

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    <p>A: control epithelium; B, C, D, E and F: invasive cervical cancer epithelium. (A) Negative; (B) Focal moderate nuclear and cytoplasmatic expression; (C) Diffuse weak nuclear and cytoplasmatic expression; (D) Diffuse moderate cytoplasmatic expression; (E) Diffuse strong nuclear and cytoplasmatic expression; (F) Negative (DAB, brown stain; Mag. 40×).</p

    Ki-67 expression.

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    <p>A, B and C: control epithelium; D, E and F: invasive cervical cancer epithelium. (A) Negative; (B) Strict positive stain in the basal layer; (C) positive stain in the basal and intermediate layer; (D) less than 25% of positive cells all over the epithelium; (E) 25–50% of positive cells all over the epithelium; (F) more than 50% of positive cells all over the epithelium (DAB, brown stain; Mag. 40×).</p
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