Visual abstracts to disseminate research on Twitter: a quantitative analysis

The Web has indisputably changed the way researchers share information. Web-based scholarly communication allows to rapidly disseminate research findings, to reach a broader audience, to transversely connect different contents through hypertext linkages, to update and correct texts if needed, and to integrate multimedia materials. Moreover, it allows interactivity and real-time exchange between authors and readers. Such features are even more evident in the context of the so-called Web 2.0, which involves user-generated content, data sharing, and collaborative efforts. The diffusion of social software and web-based applications has lead to a new use of the Web as a platform for generating, re-purposing and consuming scientific content. Social media brought additional advantages and challenges: they help to fulfill the demand for cheap, instant communication in a context of growing collaborative and interdisciplinary research, but they also, for example, add complexity in terms of quantification of the impact of scientific articles. Nevertheless, researchers are now using social media platforms in every phase of the research lifecycle, from identifying opportunities to disseminating findings. In particular, Twitter, the microblogging platform that allows users to post/publish short messages up to 140 (now 280) characters, has emerged as a powerful tool in scholarly communication. Indeed, it connects researchers around the world (both within and outside one\u2019s research field), giving them the chance to communicate and discuss research findings with the rest of the scientific community, to provide and receive post-publication critiques, and to increase the reach and the impact of their work. Recently, also scientific journals adopted social media, and Twitter in particular, to disseminate research findings published on their pages and websites. In the field of biomedical research, this led to the development of new strategies of dissemination..

Interacción entre objetos matemáticos y representaciones semióticas en diferentes escenarios de aprendizaje. Diseño de situaciones didácticas

Consideramos que desde nuestras prácticas docentes y teniendo en cuenta la diversidad de los objetos matemáticos, sus significados y representaciones, es posible diseñar estrategias de enseñanza a fin de lograr una adecuada aprehensión de los mismos. La coordinación de diversas actividades con aplicaciones propias de la matemática como las vinculadas a las ciencias en general, contribuye a modificar la visión negativa que algunos alumnos poseen de esta disciplina y a disminuir la deserción que frecuentemente se produce en los primeros años de la universidad. En la búsqueda de soluciones a esta problemática y en el marco de un proyecto de investigación que desarrollamos en la UNLPam, implementamos actividades con los estudiantes, que contribuyeron a resignificar los contenidos propios de Matemática, fomentar el trabajo autónomo y fortalecer capacidades como: argumentar, relacionar, aplicar, entre otras

A Borehole Muon Telescope for Underground Muography

Radiographic imaging with muons by absorption, also called Muon Radiography or Muography, is a methodology based on the characteristic of the matter to be crossed by high energy muons. This physical property allows muons to pass through the material with a measurable degree of absorption depending on the density of the material. Muon Radiography applies to several different situations and is particularly suitable for investigating subsoil of civil or archaeological interest. This kind of applications needs the muon detector to be installed below the target region. A novel borehole cylindrical detector has been built and tested for use in harsh conditions and for limited space installations. It is based on the past expertise with scintillator detectors and is composed of two types of scintillating elements, bar-shaped and arcshaped. Due to its size, it can be easily installed in drilled holes of 25 cm in diameter or more, typically economical to make. Here, we describe the idea, commissioning, and some preliminary results

Muon Radiography Investigations in Boreholes with a Newly Designed Cylindrical Detector

Muons are constantly produced in cosmic-rays and reach the Earth surface with a flux of about 160 particles per second per square meter. The abundance of muons with respect to other cosmic particles and their capability to cross dense materials with low absorption rate allow them to be exploited for large scale geological or human-made object imaging. Muon radiography is based on similar principles as X-ray radiography, measuring the surviving rate of muons escaping the target and relating it to the mass distribution inside the object. In the course of decades, after the first application in 1955, the methodology has been applied in several different fields. Muography allows us to measure the internal density distribution of the investigated object, or to simply highlight the presence of void regions by observing any excess of muons. Most of these applications require the detector to be installed below the rock being probed. In case that possible installation sites are not easily accessible by people, common instrumentation cannot be installed. A novel borehole cylindrical detector for muon radiography has been recently developed to deal with these conditions. It has been realized with a cylindrical geometry to fit typical borehole dimensions. Its design maximizes the geometrical acceptance, minimizing the dead spaces by the use of arc-shaped scintillators. The details of the construction and preliminary results of the first usage are described in this paper

Muography applied to nuclear waste storage sites

Legacy storage sites for nuclear waste can pose a serious environmental problem. In fact, since certain sites date from the middle of the last century when safety protocols had not been properly established and strict bookkeeping was not enforced, a situation has evolved where the content of storage silos is basically known only with a large uncertainty both on quantity and quality. At the same time maintenance work on old storage structures is becoming ever more urgent and yet this work requires exactly that information which is now lacking on the type of waste that was stored inside. Because of the difficulty in accessing the storage silos and the near impossibility of making visual inspections inside, techniques have to be developed which can determine the presence or absence of heavy elements (i.e. uranium) within the structures. Muography is a very promising technique which could allow the survey of previously inaccessible structures. We have begun an evaluation performing feasibility studies using simulations based on real case scenarios. This paper will outline the storage site scenarios and then present some of the results obtained from the Monte Carlo simulations

Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine

Despite the availability of over 20 antiepileptic drugs, about 30% of epileptic patients do not achieve seizure control. Thus, identification of additional molecules targeting novel molecular mechanisms is a primary effort in today’s antiepileptic drug research. This paper reviews the pharmacological development of retigabine, an antiepileptic drug with a novel mechanism of action, namely the activation of voltage-gated potassium channels of the Kv7 subfamily. These channels, which act as widespread regulators of intrinsic neuronal excitability and of neurotransmitter-induced network excitability changes, are currently viewed among the most promising targets for anticonvulsant pharmacotherapy. In particular, the present work reviews the pathophysiological role of Kv7 channels in neuronal function, the molecular mechanisms involved in the Kv7 channel-opening action of retigabine, the activity of retigabine in preclinical in vitro and in vivo studies predictive of anticonvulsant activities, and the clinical status of development for this drug as an add-on treatment for pharmacoresistant epilepsy. Particular efforts are devoted to highlighting the potential advantages and disadvantages of retigabine when compared with currently available compounds, in order to provide a comprehensive assessment of its role in therapy for treatment-resistant epilepsies

a possible point of contact between cosmic ray physics and archaeology muon absorption radiography at the tharros phoenician roman site

Several on-going activities exploiting the potential of the muon-absorption radiography technique are focusing on the study of large volcanic structures located in different geographical regions. Nonetheless, the possible application of this non-destructive surveying method to other fields is also under consideration by different groups. Looking backward to the history of muon radiography, we can learn how the first important success of this technique was achieved in the archaeological field by the physicist Luis W. Alvarez in the 1960s. Further examples of possible applications can be found concerning geological and mining applications. In this paper a possible application of muon absorption radiography in the context of the archaeological research is proposed. Results of a simulation of a simplified case study are presented

a geant4 framework for generic simulations of atmospheric muon detection experiments

A flexible and adaptive simulation framework based on Geant4 is presented. The framework has been developed in order to speed up the deployment of full-featured Monte Carlo simulation codes for small/medium sized particle detection experiments with generic geometries. Specific components related to atmospheric muon experiments have been developed and are presented as well

The MURAVES muon telescope: technology and expected performances

The MURAVES project aims to study the inner structure of the upper part of the Mt. Vesuvius volcano by muon radiography (muography) technique. Very high energy muons, produced by cosmic rays in the at- mosphere, can penetrate large thickness of rocks. By measuring the at- tenuation of the muons flux trough the volcano cone is possible to obtain a 2D image of the density structure. Internal discontinuities, with a spa- tial resolution of about 10 m, can be, in principle, resolved. An absolute average density measurement can be provided too. The project, funded by the Italian Ministry of University, Research and Education (MIUR), is led by INGV and INFN. In this article the mechanical structure of the de- tectors and background suppression techniques are reported

The MURAVES telescope front-end electronics and data acquisition

The MURAVES detector is a 4 m 2 muon tracker equipped with a low power consumption electronic and designed to work in volcanic areas. Due to the great amount of channels (~1500) the detector is equipped with a multilayer electronic for data acquisition. It consists of 12 slave boards and 1 master board per square meter of detector and a single Raspberry Pi board that rules the whole set of one-square-meter detectors. Because of this modularity, we can enlarge in principle the detector surface by adding more one-square-meter elements. In the present work, we resume the main features of the MURAVES detector designed for the muography of volcanoes and, more generally, for the imaging of the underground. We focus on the capability to fine tune every single channel of the detector and the precise measure of the time of flight of the muons. The latter uses a time expansion technique and it should allow us to make a background rejection never obtained until now