Within subject variability of repeated tTI measurements.

<p>Shown are median (range) coefficients of variation (CV) of repeated tTI measurements for corresponding VT levels at different PEEP levels Pre- and Post-lavage for n = 5 animals. Repeated measurements are taken at different time points during variation at one PEEP level.</p

Bland-Altman Plot for comparison between VT_calc and VT_PNT during pre-lavage measurements.

<p>Shown are Line of Identity (grey line), Bias (blue line), and 95%-Limits of Agreement (dashed line). Calibration was performed at each PEEP level in all animals. Data points indicate the means of measurements in individual piglets at different PEEP levels.</p

Distribution of fTI in different quadrants at different VT, pre-lavage.

<p>Shown are mean (grey line) fTI values for different VT, with 95%-Confidence Interval of the mean (green diamonds).</p

Distribution of fTI in different quadrants at different VT, post-lavage.

<p>Shown are mean (grey line) fTI values for different VT, with 95%-Confidence Interval of the mean (green diamonds).</p

Placement of electrodes.

<p>a) Schematic map of the piglet's body and position of electrodes; b) detailed illustration of the sternum and distances of the electrodes; the length of the sternum (s) is quartered. Cranial Right (CrR) and Cranial Left (CrL) ventral are set at the end of the first quarter from the cranial end of the sternum right and left with the distance ¼ s from the axis. The central electrode for current injection (CE) is set in the middle (m) of the remaining ¾ of the sternum. Caudal Right (CaR) and Caudal Left (CaL) are placed right and left from the caudal end of the sternum with the distance between m and the caudal end of the sternum. Dorsal electrodes are set mirror-inverted to the ventral electrodes.</p

Distribution of fTI at different VT stratified according to PEEP, pre-lavage.

<p>Shown are mean fTI values (grey line) for different VT at different PEEP with 95%-Confidence Interval of the mean (green diamonds).</p

Tracing signal of impedance measurement during 5 breathing cycles.

<p>Shown are tracing signals of QIM measurements from 4 quadrants during 5 respiratory cycles. In addition flow and pressure curves from the ventilator are shown below in order to illustrate the time course of impedance changes with respect to ventilatory cycles from the ventilator.</p

Bland-Altman Plot for comparison between VT_calc and VT_PNT during post-lavage measurements.

<p>Shown are Line of Identity (grey line), Bias (blue line), and 95%-Limits of Agreement (dashed line). Calibration was performed at each PEEP level in all animals. Data points indicate the means of measurements in individual piglets at different PEEP levels.</p