Table of simple linear regressions in CTL, CR and RSV animals.

<p>Sample size for each diet groups and Pearson correlation coefficient r are given for each regression, as dependent and independent variables. Statistical significance was considered when p<0.05 (*), p<0.001 (***), NS: non significance. Control (CTL), calorie restricted (CR), resveratrol (RSV).</p

Body mass at oral glucose tolerance test in control (CTL), calorie restricted (CR) and resveratrol supplemented (RSV) animals after 21 months of treatment (n CTL = 5, n CR = 5, n RSV = 6) and after 33 months of treatment (n CTL = 5, n CR = 5, n RSV = 8).

<p>Data are expressed as means±SEM. Statistical significance (**) p<0.01 when comparing CTL and CR animals.</p

Sample size, fasting plasma levels of insulin and HOMA-IR obtained during the OGTT after 21 months of treatment or after 33 months of treatment.

<p>Data are expressed as means±SEM. Control (CTL), calorie restricted (CR), resveratrol (RSV).</p

Plasma glucose concentrations and area under curves (AUC) during oral glucose tolerance test in control (CTL), calorie restricted (CR) and resveratrol supplemented (RSV) animals.

<p>A: after 21 months of treatment and B: after 33 months of treatment. Data are expressed as means±SEM. Statistical significance (*) p<0.05 when comparing CTL and CR animals, ($) p<0.05 when comparing CTL and RSV animals.</p

Effects of CR and RSV treatments on cognitive performances in an open field (OF) task.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0016581#pone-0016581-g004" target="_blank">Figure 4A and 4B</a> respectively represent the latency (expressed in sec) before the first movement in the open field and the total distance traveled (expressed in cm) in the open field task of control (CTL, n = 9), caloric restricted (CR, n = 9) or resveratrol supplemented (RSV, n = 10) mouse lemurs after 18 months of dietary interventions. Values are mean ± SEM.</p

Effects of CR and RSV treatments on cognitive performances in a continuous spontaneous alternation (CSA) task.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0016581#pone-0016581-g001" target="_blank">Figure 1A and B</a> respectively represents the partial and total alternation (%) in the CSA task of control (CTL, n = 6), caloric restricted (CR, n = 6) or resveratrol supplemented (RSV, n = 9) mouse lemurs after 18 months of dietary interventions. Values are mean ± SEM.</p

Effects of CR and RSV treatments on physical performances in motor tasks and spontaneous night locomotor activity.

<p>Data of control (CTL), caloric restricted (CR) or resveratrol supplemented (RSV) mouse lemurs after 18 months of dietary interventions are reported. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0016581#pone-0016581-g005" target="_blank">Figure 5A</a> represents physical performances of the animals in a jump task (expressed in cm, with n = 9 CTL, n = 11 CR and n = 10 RSV). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0016581#pone-0016581-g005" target="_blank">Figure 5B</a> represents physical performances of the animals in rotarod task (expressed in sec, with n = 7 CTL, n = 9 CR and n = 8 RSV). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0016581#pone-0016581-g005" target="_blank">Figure 5C</a> represents spontaneous night locomotor activity (expressed in arbitrary units of locomotor activity, with n = 7 CTL, n = 6 CR and n = 7 RSV). Values are mean ± SEM.</p

Effects of CR and RSV treatments on cortisol level (expressed in ng/mg of creatinine).

<p>Data of control (CTL, n = 9), caloric restricted (CR, n = 10) or resveratrol supplemented (RSV, n = 11) mouse lemurs after 18 months of dietary interventions are reported. Values are mean ± SEM.</p

Effects of CR and RSV treatments on percentage of reversal in a conditioned placed preference (CPP) task.

<p>Data of control (CTL, n = 8), caloric restricted (CR, n = 8) or resveratrol supplemented (RSV, n = 9) mouse lemurs after 18 months of dietary interventions are reported. Values are mean ± SEM.</p

Plasma fatty acids from total phospholipids of control and tuna oil supplemented animals.

1<p>Values are means ± SEM, n = 6.</p><p>*indicates significant differences between dietary treatments with p<0.01.</p>2<p>Minor fatty acids [14∶0, 15∶0, 17∶0, 19∶0, 20∶0, 22∶0, 24∶0, 14∶1(n-5), 16∶1(n-9), 20∶1(n-7), 20∶1(n-11), 22∶1(n-7), 24∶1(n-11), 24∶1(n-7), 20∶3(n-9), and 22∶3(n-9)] are not reported because they represented <0.3% of total fatty acids.</p>a<p>20∶4 n-6: Arachidonic Acid (AA),</p>b<p>20∶5 n-3: Eicosapentaenoic Acid (EPA),</p>c<p>22∶6 n-3: Docosahexaenoic Acid (DHA).</p