New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives

In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of TBARS in brain membranes and thiol peroxidase-like activity) as well as antitumoral agents in bladder carcinoma 5637. A prominent response was obtained for the selected chalcogenonucleosides, showing effective antioxidant and antitumoral activities

Kinetic growth curve of the <i>Trichomonas vaginalis</i> 30236 isolate after exposure to EOP at 500 μg/mL for 1 h, 6 h, 12 h, 24 h, 48 h, 72 h and 96 h.

<p>Data represent mean ± standard deviation of at least three experiments, all in triplicate. Different letters indicate a significant difference (p < 0.05).</p

CHO-K1 cell viability after treatment with different concentrations of EOP.

<p>Cell proliferation in CHO-K1 was investigated by the MTT assay, and metronidazole was used as a positive control. Data are expressed as the mean ± SEM of the viabilities of CHO-K1 cells in three independent experiments. (*) indicates a difference between the treatments in CHO-K1 cells. The differences were considered significant at p < 0.05. VC = vehicle control; MTZ = metronidazole.</p

Volatile compounds identified by gas chromatography followed by mass spectrometry (GC-MS) of the Brazilian red propolis essential oil.

<p>Volatile compounds identified by gas chromatography followed by mass spectrometry (GC-MS) of the Brazilian red propolis essential oil.</p

Anti-rCP40 total IgG (4A), IgG1 (4B) and IgG2a (4C) levels in immunized mice treated with EOP and recombinant endoglycosidase CP40 from <i>C</i>. <i>pseudotuberculosis</i> (rCP40), either separately or together.

<p>Measurements were taken on day 0 and then 21 and 42 days post-immunization. Data represent means ± standard deviations of IgG levels in the sera collected from 6 animals/group. Different letters in the same experimental day indicate a significant difference (p < 0.05).</p