4 research outputs found
The Mediterranean ocean Forecasting System
The Mediterranean Forecasting System (MFS) is operationally working since year 2000 and it is continuously improved in the frame of international projects. The system is part of the Mediterranean Operational Oceanography Network-MOON and MFS is coordinated and operated by the Italian Group of Operational Oceanography (GNOO). The latest upgrades and integration to MFS has been undertaken in the EU-MERSEA and BOSS4GMES Projects. Since October 2005 ten days forecasts are produced daily as well as 15 days of analyses once a week. The daily forecast and weekly analysis data are available in real time to the users through a dedicated ftp service and every day a web bulletin is published on the web site (http://gnoo.bo.ingv.it/mfs). A continuous evaluation in near real time of the forecasts and analyses produced by MFS has been developed in order to continuously verify the system and to provide useful information to the users. The R&D is focused on different aspects of the system. A new basin scale ocean model nested with operational MERCATOR global model has been developed and run in real time operationally for a test period together with a new assimilation scheme based on the 3DVAR. This system is now under evaluation. Important activities have been carried out to: implement and test a Bayesian methodologies of Ensemble and Super-Ensemble for the Mediterranean sea; produce 20 years of re-analysis; re-formulate the air-sea fluxes bulk formulae; develop dedicated products to support particular request of end users such as: indicators, real time oil spill forecasting, search & rescue.EUROGOOS and European CommissionPublishedExeter, UK4.6. Oceanografia operativa per la valutazione dei rischi in aree marineope
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A Ten-Year Real-Life Experience with Pazopanib in Uterine Leyomiosarcoma in Two High-Specialized Centers in Italy: Effectiveness and Safety
Peer reviewed: TrueAcknowledgements: Editorial support was provided by PINCH s.r.l.Publication status: PublishedBackground: Uterine leiomyosarcoma (uLMS) is characterized by aggressive behavior associated with a high risk of relapse and mortality. Several therapeutic agents have been employed in the treatment of metastatic disease, with a poor objective response rate. Pazopanib, approved in 2012, is a multi-targeted, orally active small molecule that exerts its effects by inhibiting several tyrosine kinases. To date, poor research on real-life data has been conducted. We aimed to assess the effectiveness and safety of the drug in everyday clinical practice. Methods: We present results of multicenter retrospective data on 38 patients with heavily pretreated metastatic uLMS who underwent oral pazopanib during their therapeutic journey. Results: At a median follow-up of 8.6 months, the disease control rate was 55.2%, with 17% partial responses and 15 patients (39.5%) with stable disease. At a median follow-up of 8.6 months, median progression-free survival was 4 months, and median overall survival was 19.8 months. The most common grade 3 adverse events (AEs) drug-related were hepatic toxicities, diarrhea, hypertension, nausea, and vomiting (all of them with an incidence of 5% considering the whole study cohort). No grade 4 AEs occurred. Conclusions: Pazopanib in everyday clinical practice is safe and shows a good disease control rate with prolonged survival.</jats:p
The Mediterranean ocean Forecasting System
The Mediterranean Forecasting System (MFS) is operationally working since year 2000 and it is continuously improved in the frame of international projects. The system is part of the Mediterranean Operational Oceanography Network-MOON and MFS is coordinated and operated by the Italian Group of Operational Oceanography (GNOO). The latest upgrades and integration to MFS has been undertaken in the EU-MERSEA and BOSS4GMES Projects. Since October 2005 ten days forecasts are produced daily as well as 15 days of analyses once a week. The daily forecast and weekly analysis data are available in real time to the users through a dedicated ftp service and every day a web bulletin is published on the web site (http://gnoo.bo.ingv.it/mfs). A continuous evaluation in near real time of the forecasts and analyses produced by MFS has been developed in order to continuously verify the system and to provide useful information to the users. The R&D is focused on different aspects of the system. A new basin scale ocean model nested with operational MERCATOR global model has been developed and run in real time operationally for a test period together with a new assimilation scheme based on the 3DVAR. This system is now under evaluation. Important activities have been carried out to: implement and test a Bayesian methodologies of Ensemble and Super-Ensemble for the Mediterranean sea; produce 20 years of re-analysis; re-formulate the air-sea fluxes bulk formulae; develop dedicated products to support particular request of end users such as: indicators, real time oil spill forecasting, search & rescue