学生による企画展の報告「写真で見る前身校PartⅡ～キンダイ医学の源流を辿る～」

In this article, we look back on the studentʼs exhibition “Kanazawa Universityʼs Former Schools seen in the photos, Part II : Tracing the origins of modern medicine,” at Kanazawa University (9/11/2020-20/01/2021) and it will be evaluated by the students who actuary participated in this exhibition program. Kawai and Matsunaga introduce this article, presenting the background of the special exhibition by the students at Kanazawa University as a part of the class “Museum Training” and the overview of the class schedule. Furuta discusses Chapter 2, 4, 5, 6, while Ooki discusses Chapter 3. In Chapter 2, Furuta explains the idea of this exhibition, and provides selection and research of the materials in Chapter 3, focuses on the display of the exhibition in Chapter 4, describes on the exhibition devices in Chapter 5, discuses related events in Chapter 6. Finally, Matsunaga, who is another instructor of the class and a curator of Kanazawa University Museum, considers this significance of the special exhibition conducted by the students in the University Museum

Precocious Metamorphosis in the Juvenile Hormone–Deficient Mutant of the Silkworm, Bombyx mori

Insect molting and metamorphosis are intricately governed by two hormones, ecdysteroids and juvenile hormones (JHs). JHs prevent precocious metamorphosis and allow the larva to undergo multiple rounds of molting until it attains the proper size for metamorphosis. In the silkworm, Bombyx mori, several “moltinism” mutations have been identified that exhibit variations in the number of larval molts; however, none of them have been characterized molecularly. Here we report the identification and characterization of the gene responsible for the dimolting (mod) mutant that undergoes precocious metamorphosis with fewer larval–larval molts. We show that the mod mutation results in complete loss of JHs in the larval hemolymph and that the mutant phenotype can be rescued by topical application of a JH analog. We performed positional cloning of mod and found a null mutation in the cytochrome P450 gene CYP15C1 in the mod allele. We also demonstrated that CYP15C1 is specifically expressed in the corpus allatum, an endocrine organ that synthesizes and secretes JHs. Furthermore, a biochemical experiment showed that CYP15C1 epoxidizes farnesoic acid to JH acid in a highly stereospecific manner. Precocious metamorphosis of mod larvae was rescued when the wild-type allele of CYP15C1 was expressed in transgenic mod larvae using the GAL4/UAS system. Our data therefore reveal that CYP15C1 is the gene responsible for the mod mutation and is essential for JH biosynthesis. Remarkably, precocious larval–pupal transition in mod larvae does not occur in the first or second instar, suggesting that authentic epoxidized JHs are not essential in very young larvae of B. mori. Our identification of a JH–deficient mutant in this model insect will lead to a greater understanding of the molecular basis of the hormonal control of development and metamorphosis

Cerebral Venous Thrombosis in the Superior Sagittal Sinus as a Rare Cause of a Paroxysmal Kinetic Tremor

Cerebral venous thrombosis (CVT) has a broad spectrum of clinical presentation compared to arterial etiology. Seizure is one of the common symptoms and is more frequent than in other stroke types. Hence, transient neurological symptoms in CVT patients are usually due to epileptic seizures, while transient repetitive movement disorder is extremely rare except as a complication of epilepsy. We report a case of CVT in the superior sagittal sinus with a 1-year history of paroxysmal kinetic tremor without evident epilepsy