13 research outputs found

    The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin

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    The effector protein of the canonical Wnt pathway is β-catenin, which is regulated by the ubiquitin system. This study shows that the E3 ubiquitin ligase EDD ubiquitinates β-catenin, leading to up-regulation of β-catenin's expression levels and activity. Thus the results demonstrate a role for the ubiquitin system in up-regulation of the Wnt pathway

    Physikalische und chemische Grundlagen der Lebensprozesse (Strahlenbiologie)

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    Zinc

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