19 research outputs found
A virtual globe tool for searching and visualizing geo-referenced media resources in social networks
Stereoselective formation of a K-region dihydrodiol from phenanthrene by Streptomyces flavovirens
Sorption of 17β-estradiol to the dissolved organic matter from animal wastes: effects of composting and the role of fulvic acid-like aggregates
In situ vaccination with laser interstitial thermal therapy augments immunotherapy in malignant gliomas
Human immunodeficiency virus has similar effects on brain volumetrics and cognition in males and females
Neuroglial Expression of the MHCI Pathway and PirB Receptor Is Upregulated in the Hippocampus with Advanced Aging
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention