Characterization of the clamping and internal residual stresses effects on the distortion of Inconel 718 parts resulting from turning

The understanding of phenomena related to machining processesintheaerospace industry isstill the subject of study intheresearch community. This is due to the constrained geometric tolerances to ensure optimal performance and safety. Few studies have yet focused on the effect of the clamping sequence on part distortions during the machining process. Thus, the development of machining sequences, in particular the positioning of clamping points, still requires optimisation regarding the geometry to be machined. This contribution focuses on a first step of a study that aims to characterize workpiece distortions resulting from a multi-stageprocess in relation tothe clamping, cutting forcesand the initial ormachining induced stresses. To validate the approach, an insitu methodology for characterising the defects has been developed alongside a particular workpiece holder based on an industrial procedure is set up in order to observe and limit the part distortion along the whole process.The machining sequence is divided into two machining stepsseparated by unclampingand clampingoperations. Frontal axisymmetric grooves are machined in turning on both sides of a thin Inconel718 elementary disks. These operations are subject to in situ measurement on bothside of the workpiece. A laser profilometer and laser point sensorsare usedbetween each pass and at each stage of the machining sequenceoperation. The collected data will beused in a next step to validate a numerical model that predicts the evolution of the distortions of the part during the entire machining proces

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear. We applied "explainable" machine learning, univariate, multivariate and mediation analyses of fasting plasma TMAO concentration and a multitude of phenotypes in 1,741 adult Europeans of the MetaCardis study. Here we show that next to age, kidney function is the primary variable predicting circulating TMAO, with microbiota composition and diet playing minor, albeit significant, roles. Mediation analysis suggests a causal relationship between TMAO and kidney function that we corroborate in preclinical models where TMAO exposure increases kidney scarring. Consistent with our findings, patients receiving glucose-lowering drugs with reno-protective properties have significantly lower circulating TMAO when compared to propensity-score matched control individuals. Our analyses uncover a bidirectional relationship between kidney function and TMAO that can potentially be modified by reno-protective anti-diabetic drugs and suggest a clinically actionable intervention for decreasing TMAO-associated excess cardiovascular risk

Le syndrome d'apnées du sommeil chez la personne âgée de plus de soixante ans (évaluation de l'efficacité et de la tolérance du traitement par ventilation)

LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF

Is oral microbiota linked to taste perception in human?

International audienc

Thu-P1-056 - Is taste linked to oral microbiota?

International audienceTaste perception varies strongly between individuals but the factors at the origin of this variability are not fully understood. For example, different events occurring at the vicinity of the taste receptors on the tongue can modulate taste perception. Our group has recently suggested that the microbiota at the surface of the tongue could be involved by controlling the taste compounds concentration in the lingual film (the biological material covering the tongue). The aim of this work is to evaluate the contribution of the oral microbiota to taste. To do this, taste sensitivity (5 basic tastes) was determined in 100 healthy adult subjects and the microbiota of their lingual film and saliva was characterized using quantitative metagenomics. A total of 666 bacterial species have been identified and the large majority of the species are shared between saliva and lingual film (571) but the number of non-shared species is higher in saliva. The relationship between the bacterial profiles and taste sensitivity depends on the medium considered (saliva vs lingual film) and of the taste nature. This work opens new perspectives on the implication of the oral microbiota on physiological functions occurring in the oral cavity

Is oral microbiota linked to taste perception in human?

International audienc

[Thu-P1-056] Is taste linked to oral microbiota?

International audienceTaste perception varies strongly between individuals but the factors at the origin of this variability are not fully understood. For example, different events occurring at the vicinity of the taste receptors on the tongue can modulate taste perception. Our group has recently suggested that the microbiota at the surface of the tongue could be involved by controlling the taste compounds concentration in the lingual film (the biological material covering the tongue). The aim of this work is to evaluate the contribution of the oral microbiota to taste. To do this, taste sensitivity (5 basic tastes) was determined in 100 healthy adult subjects and the microbiota of their lingual film and saliva was characterized using quantitative metagenomics. A total of 666 bacterial species have been identified and the large majority of the species are shared between saliva and lingual film (571) but the number of non-shared species is higher in saliva. The relationship between the bacterial profiles and taste sensitivity depends on the medium considered (saliva vs lingual film) and of the taste nature. This work opens new perspectives on the implication of the oral microbiota on physiological functions occurring in the oral cavity