Presumed generalised seizure following caudal epidural administration of morphine and detomidine in a pony

A 9‐year‐old show pony mare became acutely lame following removal of a bone sequestrum of the distal phalanx of the right thoracic limb. The mare also suffered from ongoing right dorsal colitis secondary to previous long‐term nonsteroidal anti‐inflammatory drug (NSAID) use. To avoid further NSAID use, a protocol for caudal epidural administration of morphine and detomidine in an increased volume was used to provide analgesia to the thoracic limbs. A total volume of 50 mL (0.2 mL/kg bwt) was administered over approximately 90 s. Immediately following the injection, the pony collapsed into lateral recumbency and experienced an apparent generalised seizure characterised by loss of consciousness and frantic paddling of all four limbs. The pony recovered rapidly without intervention, and no residual neurological deficits were noted. The epidural analgesia resulted in a marked improvement in comfort levels. The speed of injection is thought to have caused a change in epidural and intracranial pressures resulting in a generalised seizure and highlights the importance of administering large volumes slowly

Electroweak Precision Observables within a Fourth Generation Model with General Flavour Structure

We calculate the contributions to electroweak precision observables (EWPOs) due to a fourth generation of fermions with the most general (quark-)flavour structure (but assuming Dirac neutrinos and a trivial flavour structure in the lepton sector). The new-physics contributions to the EWPOs are calculated at one-loop order using automated tools (FeynArts/FormCalc). No further approximations are made in our calculation. We discuss the size of non-oblique contributions arising from Z--quark--anti-quark vertex corrections and the dependence of the EWPOs on all CKM mixing angles involving the fourth generation. We find that the electroweak precision observables are sensitive to two of the fourth-generation mixing angles and that the corresponding constraints on these angles are competitive with those obtained from flavour physics. For non-trivial 4x4 flavour structures, the non-oblique contributions lead to relative corrections of several permille and should be included in a global fit

Consistency of the mass variation formula for black holes accreting cosmological fluids

We address the spherical accretion of generic fluids onto black holes. We show that, if the black hole metric satisfies certain conditions, in the presence of a test fluid it is possible to derive a fully relativistic prescription for the black hole mass variation. Although the resulting equation may seem obvious due to a form of it appearing as a step in the derivation of the Schwarzschild metric, this geometrical argument is necessary to fix the added degree of freedom one gets for allowing the mass to vary with time. This result has applications on cosmological accretion models and provides a derivation from first principles to serve as a base to the accretion equations already in use in the literature.Comment: 4 pages, 1 figure. To appear in Gen. Rel. Gra

Discovery of a single male Aedes aegypti (L.) in Merseyside, England

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