Associação entre o esquema anti-retroviral e a idade da criança no início da terapia de AIDS

The goal of this paper was to evaluate if a child’s age at the beginning of the therapy influences the anti-retroviral scheme utilized. A transversal study was performed, utilizing the medical history data and the semi-structured interview script which contained open and closed ended questions. The data analysis was performed in SPSS utilizing a Chi-squared test, mean and standard deviation to assess the child’s age at the beginning of the treatment. It wasn’t possible to identify a relation between the anti-retroviral scheme and the age level of the children. The schemes were utilized in the same proportion, either in the up to five year old children’s group as well as in the group older than five years old. The age at the beginning of the therapy did not determine the choice for a scheme (p-value = 1.00) The professionals involved in the care of patients must be continuously rethinking, discussing and improving the processes involved on the care of an AIDS child.O objetivo do trabalho foi avaliar se a idade da criança no início da terapia influenciou no esquema anti-retroviral utilizado. Trata-se de um estudo transversal, que utiliza dados de prontuário e roteiro de entrevista semiestruturada, com perguntas abertas e fechadas. A análise dos dados foi feita pelo programa SPSS, usando-se teste chi-quadrado e média de desvio padrão para avaliar a idade da criança em início de tratamento. Não foi possível identificar uma associação entre o esquema anti-retroviral e a faixa etária das crianças. Os esquemas foram utilizados na mesma proporção, tanto no grupo de crianças até cinco anos de idade ou no grupo acima de cinco anos. A idade no início da terapia não determinou a opção pelo esquema (p-valor=1,00). Os profissionais envolvidos na assistência deverão estar continuamente repensando, discutindo e aprimorando o processo de trabalho no cuidado à criança portadora de AIDS

Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family.

There is a significant indication of the beneficial health effects of fruit rich diets. Fruitsof native plant species have noticeably different phytochemicals and bioactive effects. The aim ofthis work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ),jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and theirinfluence on antioxidant activityin vitroand antiproliferative effects on human colon adenocarci-noma cells. According to the results, dried peel powders (DP) have a high anthocyanin content,phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD).M.jaboticabadried peel powder extract had a higher total anthocyanin and phenolic compounds content(802.90±1.93 and 2152.92±43.95 mg/100 g, respectively). A reduction in cell viability of HT-29cells after treatment withM. jaboticabaextracts (DP-MJ and FD-MJ) was observed via MTT assay.Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SMhad an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cellsin relation to the control group. The findings of this study highlight the potential of peel powdersfromMyrtaceaefruits as an important source of natural antioxidants and a protective effect againstcolon adenocarcinom