49 research outputs found
Clinical evaluation of an allogeneic bone matrix containing viable osteogenic cells in patients undergoing one- and two-level posterolateral lumbar arthrodesis with decompressive laminectomy
Korrelation der Dauer der Symptomatik zu dem chirurgischen Outcome in Patienten mit zervikaler spondylotischer Myelopathie: Eine retrospektive Analyse von 248 Patienten
Evaluation of Cage Subsidence in Standalone Lateral Lumbar Interbody Fusion: Novel 3D-printed Titanium versus Polyetheretherketone (PEEK) Cage
Fusion Assessment in Standalone Lateral Lumbar Interbody Fusion: 3D-printed Titanium versus Polyetheretherketone (PEEK) cages
Veränderungen des hinteren paraspinalen und des Psoas-Muskels bei Patienten mit Kreuzschmerzen - eine 3-Jahres-Längsschnittstudie
Entscheidungsalgorithmus für die chirurgische Behandlung der degenerativen lumbalen Spondylolisthesis von L4/L5
Histological remodelling of demineralised bone matrix allograft in posterolateral fusion of the spine - an ex vivo study
BACKGROUND: Demineralised bone matrix (DBM) has shown to be effective in enhancing posterior fusion of the spine. Several animal studies and clinical investigations in humans showed its successful remodelling. The use of allogenic matrix may decrease the need of autologous bone graft and therefore helps prevent corresponding donor site morbidity. Since DBM products are very expensive, the question arises, whether it is completely remodelled into new bone, and therefore truly is comparable to autologous cancellous bone graft. To our knowledge there is no report of a consecutive series of patients where ex vivo histological analysis after postero-lateral fusion of the spine was performed.
METHODS: Osseous biopsies of nine consecutive patients who underwent postero-lateral fusion of the spine for trauma were obtained at the time of elective removal of the hardware. Histological samples were then analyzed on ground and thin sections stained with toluidine blue and von Kossa stainings.
RESULTS: Time span between index operation and removal of the metal ranged between 6 and 18Â month. Histological analysis showed good incorporation and overall remodelling of DBM into new bone in all patients. No foreign body reaction was visible and new bone formation progressed time dependently with DBM in situ. Four out of nine patients showed more than 50% new bone formation after one year.
CONCLUSION: DBM shows good overall remodelling properties in histological analysis and therefore seems to be an effective adjunct in postero-lateral fusion of the spine. Furthermore, DBM substitution increases over time