Network properties underlying seed germination control

We sought to gain a mechanistic understanding of the control of seed dormancy and germination by hormone balance. The field has matured to a stage where most of the key genes are known, and competing hypotheses have been proposed to explain how hormone balance works in seeds. During the meeting we simplified a more complex model of seed germination (Figure 1), reducing it to a tractable network. We then showed that if considered as a set of competing protein complexes the network took on the properties of a switch. Results from two models of the reduced network, which incorporated the biological switching phenomena, were found to be in good agreement with both wild and mutant phenotypic data. Our models made the novel prediction that one complex in particular was key to promoting germination, and this prediction can now be tested in the laboratory

Diffraction and scattering of high frequency waves

This thesis examines certain aspects of diffraction and scattering of high frequency waves, utilising and extending upon the Geometrical Theory of Diffraction (GTD). The first problem considered is that of scattering of electromagnetic plane waves by a perfectly conducting thin body, of aspect ratio O(k^1/2), where k is the dimensionless wavenumber. The edges of such a body have a radius of curvature which is comparable to the wavelength of the incident field, which lies inbetween the sharp and blunt cases traditionally treated by the GTD. The local problem of scattering by such an edge is that of a parabolic cylinder with the appropriate radius of curvature at the edge. The far field of the integral solution to this problem is examined using the method of steepest descents, extending the recent work of Tew [44]; in particular the behaviour of the field in the vicinity of the shadow boundaries is determined. These are fatter than those in the sharp or blunt cases, with a novel transition function. The second problem considered is that of scattering by thin shells of dielectric material. Under the assumption that the refractive index of the dielectric is large, approximate transition conditions for a layer of half a wavelength in thickness are formulated which account for the effects of curvature of the layer. Using these transition conditions the directivity of the fields scattered by a tightly curved tip region is determined, provided certain conditions are met by the tip curvature. In addition, creeping ray and whispering gallery modes outside such a curved layer are examined in the context of the GTD, and their initiation at a point of tangential incidence upon the layer is studied. The final problem considered concerns the scattering matrix of a closed convex body. A straightforward and explicit discussion of scattering theory is presented. Then the approximations of the GTD are used to find the first two terms in the asymptotic behaviour of the scattering phase, and the connection between the external scattering problem and the internal eigenvalue problem is discussed

Brown Condor

The true story of an African American pilot, John Robinson, who broke through racial barriers to become a pilot and commander of the Ethiopian Air Force in their 1935 fight for freedom against fascist Italy

Multiscale models in the biomechanics of plant growth

Plant growth occurs through the coordinated expansion of tightly adherent cells, driven by regulated softening of cell walls. It is an intrinsically multiscale process, with the integrated properties of multiple cell walls shaping the whole tissue. Multiscale models encode physical relationships to bring new understanding to plant physiology and development

Measuring glucose content in the aqueous humor

Many diabetics must measure their blood glucose levels regularly to maintain good health. In principle, one way of measuring the glucose concentration in the human body would be by measuring optically the glucose content of the aqueous humor in the eye. Lein Applied Diagnostics wish to assess whether this is feasible by a linear confocal scan with an LED source, or by supplementing such a system with other measurements

Vertex-element models for anisotropic growth of elongated plant organs

New tools are required to address the challenge of relating plant hormone levels, hormone responses, wall biochemistry and wall mechanical properties to organ-scale growth. Current vertex-based models (applied in other contexts) can be unsuitable for simulating the growth of elongated organs such as roots because of the large aspect ratio of the cells, and these models fail to capture the mechanical properties of cell walls in sufficient detail. We describe a vertex-element model which resolves individual cells and includes anisotropic non-linear viscoelastic mechanical properties of cell walls and cell division whilst still being computationally efficient. We show that detailed consideration of the cell walls in the plane of a 2D simulation is necessary when cells have large aspect ratio, such as those in the root elongation zone of Arabidopsis thaliana, in order to avoid anomalous transverse swelling. We explore how differences in the mechanical properties of cells across an organ can result in bending and how cellulose microfibril orientation affects macroscale growth. We also demonstrate that the model can be used to simulate growth on realistic geometries, for example that of the primary root apex, using moderate computational resources. The model shows how macroscopic root shape can be sensitive to fine-scale cellular geometries