2,140 research outputs found
Recommended from our members
Urban Heat Islands Strategy Plan Vienna â Implementing Urban Green Infrastructure to Reduce Negative Effects of Urban Heat Islands
Urban heat islands (UHI) have been known since the 19th century (Howard, 1820) and describe the difference in temperature between cities and their rural surroundings. This difference can be up to 12°C (Eliasson, 2000, 31); the phenomenon is caused by the transformation of natural surfaces through e.g. soil sealing, construction of infrastructure and buildings. However, differences in temperature not only occur between cities and their adjacent areas, but also within different parts of cities depending on the provision of green and blue infrastructure as well as on their share of sealed surfaces. The situation is further aggravated by a changing climate. Numerous studies state that the number of heat days (maximum temperature of at least 30°C) as well as the number and duration of heat waves will increase worldwide â especially in cities due to their sealed surfaces, building density and lack of green space (Formayer et al., 2008; Bowler et al., 2010). This problem will become even more crucial in the future: in 2005 approx. half of the world population lived in urban regions and this number is predicted to rise by up to nearly two thirds by 2050 (SchlĂŒnzen, 2012). Consequences of those growing cities and expanding urban areas are further densification of settlement areas and loss of open and green space; this strengthens the urban heat islands effect even more. Urban heat islands can have negative effects on human health and wellbeing with sensitive groups such as the elderly being especially affected (Allex et al., 2013).
To counteract UHI and their negative effects, the âUrban Heat Islands Strategy Plan Viennaâ has been elaborated as part of a Central Europe project (www.http://eu-uhi.eu/, 2011-2014). The aim was the development of a strategy for the City of Vienna to implement open space planning as well as urban ecology measures to reduce the negative aspects of UHI. Within the project, a guideline has been elaborated by the project team and members of the Environmental Protection Department Vienna (MA 22) to support planners, architects as well as members of the Vienna City Administration, to show possibilities of technical and strategic measures against UHI as well as their potential to reduce urban heat, and to point out planning tools and planning levels. The guideline is available online (https://www.wien.gv.at/umweltschutz/raum/uhi-strategieplan.html, in German)
The Contribution of Public Spaces to Climate Change Adaptation in Austrian Cities
Cities and urban areas are particularly affected by the impacts of climate change, especially by rising
temperatures and more frequent and heavier rainfall events. Adapting spatial development to the
consequences of climate change is being increasingly anchored as a goal in Austrian and European policies
and planning strategies. Larger cities are active in setting strategic climate change adaptation (CCA) goals
and implementing measures at local scale. Urban green and blue infrastructure (UGBI) and their ecosystem
services (ESS) are one of the most effective measures for coping with the consequences of climate change.
Urban ecosystems are essential for the urban climate and urban residents due to their regulating (e.g.
reduction of the urban heat island effect), supporting (e.g. increase in biodiversity), provisioning (e.g. water
filtration) and socio-cultural (e.g. benefits for health, wellâbeing, recreation) functions.
In built-up areas, public space is one of the most important spatial resource for implementing CCA measures
and especially UGBI. While steering mechanisms on private properties often fail due to lack of authorisation,
instruments or legal regulations, the planning and design of public space is the direct responsibility of cities
as local planning authorities. However, in public space, CCA measures and UGBI have to compete with
other demands and interests, such as recreation, social interaction and communication, mobility or energy
production. As cities grow and densify, pressure on public space increases. Therefore, CCA and CCA
measures â both for private and public spaces â need to be mainstreamed into policies at all levels and
subsequently integrated into formal planning instruments and planning processes.
Our paper investigates the horizontal and vertical integration of CCA, and especially CCA in public space
(streets, squares and parks), into Austrian planning-related policies on national, federal state and municipal
level and critically reflects on the mechanisms for implementation in planning practice. The research is based
on i) a comprehensive analysis of policy documents of four Austrian federal states (Vienna, Styria, Salzburg
and Upper Austria) and cities (Vienna, Graz, Salzburg, Wels), and ii) expert interviews with members of
federal state and municipal planning administrations. The policy documents include CCA strategies that have
an impact on planning and explicit spatial development strategies. The results show a emerging
manifestation of CCA in policy documents, though not yet consistently at all levels and in all municipalities.
Measures for CCA in public space are mainly anchored at municipal level, as cities already operate actively
out of a given urgency. Despite the integration of CCA measures into the strategic planning level, our
research shows that implementation still faces obstacles in planning practice. Our study highlights the
importance of political agenda setting for the realization of CCA measures in public space and discusses
success factors and implementation gaps
Urban green infrastructure planning as a contribution to the smart âgreenâ city
The urban green infrastructure is getting due to the strong growth of the City of Vienna under increasing pressure. A foresighted planning of green and open spaces is necessary to obtain the different "Ecosytem Services" - provision-related services, regulatory services, cultural services and support services (MEA 2005). Additionally an increase in the number of hot days and thus an increase of the heat load in the city is predicted for Vienna (ZAMG 2012). Again, making a foresighted planning of green and open spaces is a significant contribution to meet these climatic challenges (Kuffner A. 2012, Hagen et al. 2010). Based on the concept of "green infrastructure" (Pauleit et al. 2011) and the ecosystem services of these, it is shown which contribution - in particular to reduce the heating of the city - they can make to the Smart City concept
Possibilities and Opportunities of Mobile Devices to Measure the Physical (In)Activity of Young Citizens â First Results of a Case Study in Vienna
âNew Mediaâ starting with the introduction of television followed by Video to DVDs and computer games are often made responsible for the lack of movement and outdoor exercises of young people. With the spread of mobile devices such as smartphones and tablet computers, digital tools became spatially independent which offers new options and possibilities especially among young people (Direito et al. 2014). Instead of blaming new media as a reason that the young people increasingly stay at home and neglecting physical activities, the possibilities and opportunities of particularly mobile devices are to be examined in the project âActivE Youthâ. The project aims to determine how mobile devices can contribute for collecting data regarding the mobility behavior of the youth and how mobile devices can be used to reduce the lack of physical activity of young people
Nutrient availability regulates proline/alanine transporters in Trypanosoma brucei
Trypanosoma brucei is a species of unicellular parasite that can cause severe diseases in livestock and humans, including African trypanosomiasis and Chagas disease. Adaptation to diverse environments and changes in nutritional conditions is essential for T. brucei to establish an infection when changing hosts or during invasion of different host tissues. One such adaptation is the ability of T. brucei to rapidly switch its energy metabolism from glucose metabolism in the mammalian blood to proline catabolism in the insect stages and vice versa. However, the mechanisms that support the parasite's response to nutrient availability remain unclear. Using RNAseq and qRT-PCR, we investigated the response of T. brucei to amino acid or glucose starvation and found increased mRNA levels of several amino acid transporters, including all genes of the amino acid transporter AAT7-B subgroup. Functional characterization revealed that AAT7-B members are plasma membrane-localized in T. brucei and when expressed in Saccharomyces cerevisiae supported the uptake of proline, alanine, and cysteine, while other amino acids were poorly recognized. All AAT7-B members showed a preference for proline, which is transported with high or low affinity. RNAimediated AAT7-B downregulation resulted in a reduction of intracellular proline concentrations and growth arrest under low proline availability in cultured procyclic form parasites. Taken together, these results suggest a role of AAT7-B transporters in the response of T. brucei to proline starvation and proline catabolism
Recommended from our members
Sustainable Management of Urban Green Infrastructure â The Challenge of Providing High-Quality Green in Multi-Storey Residential Construction
Vienna is known as one of the most liveable cities worldwide (Mercer, 2015), not least because of Viennaâs green infrastructure (GI). These qualities of life and the trend of urbanisation lead to strong population growth in Vienna. It is predicted that the Viennese population will grow from 1.8 million (2015) to 2 million in 2029 (MA 23, 2014); to offer living space, the creation of up to 120,000 new homes is planned until 2050 (MA 18, 2014). The growth and the resulting exploitation pressure on the (green) areas pose a major challenge for the City of Vienna. The loss of green space induced by land use results in the reduction or loss of ecosystem services. The negative effects of the decline of green areas and the increasing soil sealing already occur especially in areas of high population density. Furthermore, increasing heat stress and risks related to natural disasters like the flood event in 2002 show the importance of green space in urban areas for the maintenance of ecosystem functions. Therefore, a challenge of the next years will be to maintain a high-quality and efficient network of GI.
At the moment, the floor area ratio (âGeschoĂflĂ€chenzahlâ) and other values like the degree of soil sealing, the density rate for buildings, building heights etc. are the defining parameters for urban development in Vienna and regulate the degree of building coverage. The supply of the neighbourhoods with open/green space is determined only indirectly. Besides, those parameters are not able to state the quality of green space for humans. Vienna has already recognised the importance of GI and develops guides for developers and urban planners to contribute to encourage GI in the city (MA 18, 2014; MA 22, 2013; MA 22, 2015). But a clear framework for the conservation and provision of minimum standards for urban green space, however, is still missing; incentives for implementation of GI elements are primarily given through grants.
Some cities have developed defining parameters or policy instruments for
GI to enable a management of open space supply and quality (e.g. Berlin: âBiotope Area Factorâ; Malmö: âGreen Space Factorâ; Seattle: âGreen
Factorâ, Helsinki...), but in the current practice of applying the green space factors almost only ecological aspects are taken into account (Kruuse, 2011; Szulczewska et al., 2014). Socio-cultural aspects such as usability, aesthetics or recreation are rarely considered. For urban planning and administration it would be important to start thinking about a green space factor which, beneath size and space consumption, also takes into account socio-cultural aspects.
The main objective of the âAddedValueGreen!â project was to develop a green
and open space factor (âGrĂŒnflĂ€chenfaktorâ or âGFFâ) which encompasses regulating, socio-cultural and economic effects of urban GI (uGI). The focus was on the management and intervention of private and housing-related spaces to secure a certain amount of high-quality open/green space on building lots. Through the evaluation of housing projects by using the GFF, deficits in the green space supply and quality can be identified and recommendations to improve the GI can be derived. Furthermore, it will be possible to integrate this evaluation tool into other planning levels or management tools
Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling
In platelets, the nitric oxide (NO)âinduced cGMP response is indicative of a highly regulated interplay of cGMP formation and cGMP degradation. Recently, we showed that within the NO-induced cGMP response in human platelets, activation and phosphorylation of phosphodiesterase type 5 (PDE5) occurred. Here, we identify cyclic GMP-dependent protein kinase I as the kinase responsible for the NO-induced PDE5 phosphorylation. However, we demonstrate that cGMP can directly activate PDE5 without phosphorylation in platelet cytosol, most likely via binding to the regulatory GAF domains. The reversal of activation was slow, and was not completed after 60 min. Phosphorylation enhanced the cGMP-induced activation, allowing it to occur at lower cGMP concentrations. Also, in intact platelets, a sustained NO-induced activation of PDE5 for as long as 60 min was detected. Finally, the long-term desensitization of the cGMP response induced by a low NO concentration reveals the physiological relevance of the PDE5 activation within NO/cGMP signaling. In sum, we suggest NO-induced activation and phosphorylation of PDE5 as the mechanism for a long-lasting negative feedback loop shaping the cGMP response in human platelets in order to adapt to the amount of NO available
Rapid nitric oxideâinduced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme
Most of the effects of the signaling molecule nitric oxide (NO) are mediated by cGMP, which is synthesized by soluble guanylyl cyclase and degraded by phosphodiesterases. Here we show that in platelets and aortic tissue, NO led to a biphasic response characterized by a tremendous increase in cGMP (up to 100-fold) in less than 30 s and a rapid decline, reflecting the tightly controlled balance of guanylyl cyclase and phosphodiesterase activities. Inverse to the reported increase in sensitivity caused by NO shortage, concentrating NO attenuated the cGMP response in a concentration-dependent manner. We found that guanylyl cyclase remained fully activated during the entire course of the cGMP response; thus, desensitization was not due to a switched off guanylyl cyclase. However, when intact platelets were incubated with NO and then lysed, enhanced activity of phosphodiesterase type 5 was detected in the cytosol. Furthermore, this increase in cGMP degradation is paralleled by the phosphorylation of phosphodiesterase type 5 at Ser-92. Thus, our data suggest that NO-induced desensitization of the cGMP response is caused by the phosphorylation and subsequent activity increase of phosphodiesterase type 5
KrĂ€uter fĂŒr Nutz- und Heimtiere: Ratgeber fĂŒr die Anwendung ausgewĂ€hlter Heil- und GewĂŒrzpflanzen
Dieser Ratgeber fĂŒhrt wissenschaftliche Erkenntnisse und traditionelles Hausmittelwissen zusammen, beleuchtet alles Wissenswerte zu ĂŒber 50 Heilpflanzen und gibt konkrete Anwendungsbeispiele. Ziel ist es, altbewĂ€hrte Pflanzenanwendungen wieder mehr in die moderne Tierhaltung einzubinden.
Der anwenderorientierte Aufbau des Buches ermöglicht es dem Leser, Kenntnisse ĂŒber die verschiedenen Zubereitungen und Anwendungen von Heilpflanzen zu erwerben und diese in der Praxis einzusetzen. Zubereitung, Aufbewahrung und Anwendung von KrĂ€utern, sowie deren Wirkung und Einsatz bei einzelnen Tierarten werden ausfĂŒhrlich dargestellt.
âDie Aufgabe heutiger Wissenschaft ist weniger die Suche nach neuen wirksamen Pflanzen, vielmehr die ĂberprĂŒfung und Absicherung dieses althergebrachten Wissensschatzes im Lichte moderner Erkenntnisse. Das Autorenteam setzt sich aus jungen engagierten Wissenschaftlern und TierĂ€rzten zusammen. Ihnen ist es ein groĂes Anliegen, dass die Erkenntnisse der KrĂ€uterheilkunde möglichst vielen Tierhaltern â insbesondere ihren Tieren â von Nutzen sein werden.
Es bleibt der Wunsch: die vielen praktischen Anleitungen mögen einen starken Impuls zur Wiederbelebung der KrĂ€uterheilkunde bei Tieren geben.â
Dr. Gerhard Plakol
Relationship between shear energy input and sedimentation properties of exopolysaccharide-producing strains
separation of the bacteria cells. This separation is most commonly carried out with disc stack separators and needs to be adjusted to the respective strain to obtain a high cell recovery rate. Exopolysaccharides (EPS) produced by several starter cultures, however, have a large negative impact on the separation properties of the cells. These EPS can be divided into cell-bound capsular EPS or free EPS that are released into the surrounding fermentation medium. To improve the separation step, shear forces were applied after fermentation with a gear ring disperser to simulate the impact of a homogenizer and the influence on the separation properties of six Streptococcus thermophilus strains was examined. In case of capsular EPS, the sedimentation velocity of the bacteria increased due to shearing off the capsular EPS layer. Shearing media with free EPS resulted in a viscosity decrease and, hence, in a higher sedimentation velocity, as was determined using a disc centrifuge and a LUMiSizer. Sediment compression as measured with the LUMiSizer was also affected by the shearing step. The results of this study suggest that a defined shear treatment of EPS producing bacterial starter cultures leads to improved separation properties and, hence, higher bacteria yields. We assume that both EPS types affect separation efficiency of the bacteria cells, free EPS because of increased media viscosity and capsular EPS because they act like a friction pad
- âŠ