Pharmacokinetics, clinical and safety outcomes of Pyronaridine/artesunate Treatment of Acute Plasmodium falciparum Malaria in Uganda

Presented at the conference of the American Society of Tropical Medicine and Hygiene 200

The chiral anomaly in real space

The chiral anomaly is based on a non-conserved chiral charge and can happen in Dirac fermion systems under the influence of external electromagnetic fields. In this case, the spectral flow leads to a transfer of right- to left-moving excitations or vice versa. The corresponding transfer of chiral particles happens in momentum space. We here describe an intriguing way to introduce the chiral anomaly into real space. Our system consists of two quantum dots that are formed at the helical edge of a quantum spin Hall insulator on the basis of three magnetic impurities. Such a setup gives rise to fractional charges which we show to be sharp quantum numbers for large barrier strength. Interestingly, it is possible to map the system onto a quantum spin Hall ring in the presence of a flux pierced through the ring where the relative angle between the magnetization directions of the impurities takes the role of the flux. The chiral anomaly in this system is then directly related to the excess occupation of particles in the two quantum dots. This analogy allows us to predict an observable consequence of the chiral anomaly in real space.Comment: 7 pages, 5 figure

GABA increases electrical excitability in a subset of human unmyelinated peripheral axons

A proportion of small diameter primary sensory neurones innervating human skin are chemosensitive. They respond in a receptor dependent manner to chemical mediators of inflammation as well as naturally occurring algogens, thermogens and pruritogens. The neurotransmitter GABA is interesting in this respect because in animal models of neuropathic pain GABA pre-synaptically regulates nociceptive input to the spinal cord. However, the effect of GABA on human peripheral unmyelinated axons has not been established

Reality Based Teaching In Technology Education

Technology education is a diverse and dynamic academic discipline. As such it is virtually impossible to possess and maintain expertise in all that it encompasses. One method of helping a teacher gain proper insight and perspective into the essential content of a course is through participation in an extemship. This study called for getting the teacher out of the classroom and into industry (specifically the design/engineering field) in order to witness first hand the skills and processes necessary. Seven design/engineering firms were visited and consulted. Data gathered from interviews and observations can be applied to develop a more relevant technology curriculum

SLIDES: Shale Drilling and Completions

Presenter: William Fleckenstein, BP Adjunct Professor in the Petroleum Department and Director of PERFORM Research, Colorado School of Mines, Golden, CO, and Managing Partner of Fleckenstein, Eustes & Associates 20 slide

Supported metal complexes: From mesoporous silica to 3D printed polymers

The drive to find heterogeneous catalysts for known and new reactions is of great interest. This interest comes from the increase in stability of the catalyst, the ease of separation from the reaction, and the ability to reuse the catalyst. In recent years, mesoporous silica has emerged as a very beneficial support for catalysts due to its highly Si-OH rich surface and immense surface area per gram. A new zinc complex supported on the surface of SBA-15 type mesoporous silica nanoparticles (MSN) has been discovered. This system thus far been tested for hydrosilylation of carbonyl containing compounds and epoxidation of α, β-unsaturated ketones. The deprotonation of silanols on the surface of MSN with ZnEt2 leads to the immobilization of ZnEt on the surface of MSN (MSN-ZnEt). Suspending MSN-ZnEt in an alcoholic solvent will lead to the corresponding MSN-ZnOR. MSN-ZnEt, MSN-ZnOEt, MSN-ZnOtBu and MSN-ZnOOtBu. Each of these MSN-Zn complexes have been isolated. MSN-ZnEt and MSN-ZnOEt have been characterized with FTIR, ICP-OES, BET, chemisorption, and TEM. In the last few years additive manufacturing has begun to be incorporated into the chemical world by 3D printing custom chemical reactors for specific reactions and functionalized filament. We have successfully used stereolithography (SLA) three-dimensional (3D) printing, which photopolymerizes acrylic resin into a solid polymer, to create catalyst inserts that vary in surface area and contain a transition metal catalyst. Also, we have used SLA printing to create a unique reactor design to allow gas to flow into the vessel and hold up to 5 bar of pressure while also being able to release this pressure safely