15 research outputs found
Differential effects of nickel dosages on in vitro and in vivo seed germination and expression of a high affinity nickel-transport family protein (AT2G16800) in trembling aspen (Populus tremuloides)
No full textBone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression
No full text
MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling
No full textDrug Insight: the use of bisphosphonates for the prevention and treatment of osteoporosis in men
No full textLongitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice
No full textMicroglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice
No full textAntibiotics in the clinical pipeline in 2011
No full textPotential research participants may assume that randomized trials comparing new interventions with older interventions always hypothesize greater efficacy for the new intervention, as in superiority trials. However, antibiotic trials frequently use "noninferiority" hypotheses allowing a degree of inferior efficacy deemed "clinically acceptable" compared with an older effective drug, in exchange for nonefficacy benefits (eg, decreased adverse effects). Considering these different benefit-harm trade-offs, proper informed consent necessitates supplying different information on the purposes of superiority and noninferiority trials
