1,259 research outputs found
La puñalada : argumento del melodrama lĂrico en un acto dividido en un prĂłlogo y cuatro cuadros, en prosa y en verso, original de Carlos Fernández Saw, mĂşsica del maestro Ruperto ChapĂ
Copia digital. Valladolid : Junta de Castilla y LeĂłn. ConsejerĂa de Cultura y Turismo, 2009-201
Prevalence and Predictors of Vitamin D Insufficiency in Children: A Great Britain Population Based Study
Objectives
To evaluate the prevalence and predictors of vitamin D insufficiency (VDI) in children In Great Britain.
Design
A nationally representative cross-sectional study survey of children (1102) aged 4–18 years (999 white, 570 male) living in private households (January 1997–1998). Interventions provided information about dietary habits, physical activity, socio-demographics, and blood sample. Outcome measures were vitamin D insufficiency (<50 nmol/L).
Results
Vitamin D levels (mean = 62.1 nmol/L, 95%CI 60.4–63.7) were insufficient in 35%, and decreased with age in both sexes (p<0.001). Young People living between 53–59 degrees latitude had lower levels (compared with 50–53 degrees, p = 0.045). Dietary intake and gender had no effect on vitamin D status. A logistic regression model showed increased risk of VDI in the following: adolescents (14–18 years old), odds ratio (OR) = 3.6 (95%CI 1.8–7.2) compared with younger children (4–8 years); non white children (OR = 37 [95%CI 15–90]); blood levels taken December-May (OR = 6.5 [95%CI 4.3–10.1]); on income support (OR = 2.2 [95%CI 1.3–3.9]); not taking vitamin D supplementation (OR = 3.7 [95%CI 1.4–9.8]); being overweight (OR 1.6 [95%CI 1.0–2.5]); <1/2 hour outdoor exercise/day/week (OR = 1.5 [95%CI 1.0–2.3]); watched >2.5 hours of TV/day/week (OR = 1.6[95%CI 1.0–2.4]).
Conclusion
We confirm a previously under-recognised risk of VDI in adolescents. The marked higher risk for VDI in non-white children suggests they should be targeted in any preventative strategies. The association of higher risk of VDI among children who exercised less outdoors, watched more TV and were overweight highlights potentially modifiable risk factors. Clearer guidelines and an increased awareness especially in adolescents are needed, as there are no recommendations for vitamin D supplementation in older children
Las bravĂas : argumento del sainete lĂrico en un acto y cuatro cuadros, original de D. JosĂ© LĂłpez Silva y Don Carlos Fernández Shaw, mĂşsica del maestro D. Ruperto ChapĂ.
Estrenada en el Teatro de Apolo de Madrid el dĂa 12 de Diciembre de 1896
La revoltosa : argumento del sainete en un acto y tes cuadros en verso, original de D. JosĂ© LĂłpez Silva y D. Carlos Fernandez Shaw, mĂşsica del maestro R. ChapĂ.
El alma del pueblo : argumento de la zarzuela en un acto dividido en tres cuadros, original de JosĂ© LĂłpez Silva y Carlos Fernández Shaaw [sic], mĂşsica del maestro Ruperto ChapĂ.
Los buenos mozos : argumento del sainete lĂrico en un acto y cinco cuadros, original de los señores Don JosĂ© LĂłpez Silva y Don Carlos Fernández Shaw, mĂşsica del maestro Don Ruperto ChapĂ.
Estrenada en el Teatro de Apolo de Madrid la noche del 31 de Diciembre de 1899
La buena ventura : argumento de la zarzuela en un acto y cinco cuadros, original de Luis López Ballesteros y Carlos Fernández Shaw, música de los maestros Vives y Cuervós.
La chavala : argumento de la zarzuela en un acto y siete cuadros, original y en verso y prosa, letra de los señores LĂłpez Silva y Fernández Shaw, mĂşsica del maestro Don Ruperto ChapĂ.
Estrenada en Madrid en el Teatro de Apolo el dĂa 26 de octubre de 1898
Experience-based VAS values for EQ-5D-3L health states in a national general population health survey in China
Purpose: To investigate the feasibility of deriving experience-based visual analogue scale (VAS) values for EQ-5D-3L health states using national general population health survey data in China. Methods: The EQ-5D-3L was included in the National Health Services Survey (n = 120,709, aged 15–103 years) to measure health-related quality of life. The respondents reported their current health status on a VAS and completed the EQ-5D-3L questionnaire, enabling modelling of the association between the experience-based VAS values and self-reported problems on EQ-5D dimensions and severity levels. Results: VAS values were generally negatively associated with problems reported on the EQ-5D dimensions, and the anxiety/depression dimension had the greatest impact on VAS values. A previously obtained value for dead allowed the values for all 243 EQ-5D-3L health states to be transformed to the 0–1 scale (0 = dead, 1 = full health). Conclusions: This study presents the feasibility of deriving an experience-based VAS values for EQ-5D-3L health states in China. The analysis of these VAS data raises more fundamental issues concerning the universal nature of the classification system and the extent to which Chinese respondents utilise the same concepts of health as defined by this classification system
Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells
RECK is a novel tumour suppressor gene that negatively regulates matrix metalloproteinases (MMPs) and inhibits tumour invasion, angiogenesis and metastasis. In the present study, we investigated the effects of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, on the methylation status of the RECK gene and cancer invasion in oral squamous cell carcinoma cell lines. Our results showed that treatment of oral cancer cells with EGCG partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression level of RECK mRNA. Inhibition of MMP-2 and MMP-9 levels was also observed in these cells after treatment with EGCG. Interestingly, EGCG significantly suppressed cancer cell-invasive ability by decreasing the number of invasive foci (P<0.0001) as well as invasion depth (P<0.005) in three-dimensional collagen invasion model. Although further investigation is required to assess the extent of contribution of RECK on MMPs to the suppression of invasive behaviour, these results support the conclusion that EGCG plays a key role in suppressing cell invasion through multiple mechanisms, possibly by demethylation effect on MMP inhibitors such as RECK
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