Abdominal pain after endoscopic intervention

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Liver transplantation: a life-saving procedure following amatoxin mushroom poisoning

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A pilot radiologic-physiological correlative study of silicosis patients using three dimensional computed tomograph (3D-CT) lung volumetry

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Diffusion tensor MR imaging in the evaluation of Wallerian degeneration in pediatric strokes: work-in-progress

Poster Session - Pediatric Brain MR Imaging: no. 2090We use DTI to detect and quantify Wallerian degeneration (WD) in pediatric MCA strokes. Fractional anisotropy (FA) and mean diffusivity (MD)of the infarction, ipsilateral internal capsule (PLIC) and cerebral peduncle (CP) were measured in nine children and compared to the matched contralateral side. WD was characterized by statistically significant differences in FA, but not MD, of the ipsilateral PLIC and CP compared to normal side. FA was reduced in all children, whilst corresponding hyperintense signals on T2W were seen in five children. DTI is more sensitive than conventional MRI and can be used to detect and quantify WD.published_or_final_versio

Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentre randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection

Poster Presentations: Emerging / Infectious Diseases: abstract no. P107-Ab0089Symposium Theme: Translating Health Research into Policy and Practice for Health of the Populationpublished_or_final_versio

Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentre randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection

Poster Presentations: Emerging / Infectious Diseases: abstract no. P107-Ab0089Symposium Theme: Translating Health Research into Policy and Practice for Health of the Populationpublished_or_final_versio

Comparison of Small RNA Profiles of Glycine max and Glycine soja at Early Developmental Stages

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Bistability in Apoptosis by Receptor Clustering

Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas, which, on binding to its cognate ligand FasL, oligomerize to form the death-inducing signaling complex. Motivated by recent experimental data, we propose a mathematical model of death ligand-receptor dynamics where FasL acts as a clustering agent for Fas, which form locally stable signaling platforms through proximity-induced receptor interactions. Significantly, the model exhibits hysteresis, providing an upstream mechanism for bistability and robustness. At low receptor concentrations, the bistability is contingent on the trimerism of FasL. Moreover, irreversible bistability, representing a committed cell death decision, emerges at high concentrations, which may be achieved through receptor pre-association or localization onto membrane lipid rafts. Thus, our model provides a novel theory for these observed biological phenomena within the unified context of bistability. Importantly, as Fas interactions initiate the extrinsic apoptotic pathway, our model also suggests a mechanism by which cells may function as bistable life/death switches independently of any such dynamics in their downstream components. Our results highlight the role of death receptors in deciding cell fate and add to the signal processing capabilities attributed to receptor clustering.Comment: Accepted by PLoS Comput Bio

Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized contolled study

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