Poster Presentations: Emerging / Infectious Diseases: abstract no. P107-Ab0089Symposium Theme: Translating Health Research into Policy and Practice for Health of the Populationpublished_or_final_versio

Chan, K

Chan, KH

Chan, WM

Chow, FL

Hung, IFN

Lai, KY

Lau, CCY

Law, KI

Lee, CK

Lee, KH

Lin, CK

Liu, R

Liu, SH

Ngai, CW

To, KKW

Yan, WW

Yuen, KY

HKU Scholars Hub

TitleHarvesting Convalescent Plasma for Hyperimmune IntravenousGlobulin Production: A Multicentre Randomised Double-BlindControlled Trial for Treatment of Patients with Serious S-OIVH1N1 InfectionAuthor(s)Hung, IFN; To, KKW; Lee, CK; Lee, KH; Yan, WW; Chan, K; Chan,WM; Ngai, CW; Law, KI; Chow, FL; Liu, R; Lai, KY; Lau, CCY; Liu,SH; Chan, KH; Lin, CK; Yuen, KYCitationThe 2014 Health Research Symposium, Hong Kong, 15November 2014. In Programme Book, 2014, p. 58, abstract no.P107-Ab0089Issued Date 2014URL http://hdl.handle.net/10722/217535Rights Creative Commons: Attribution 3.0 Hong Kong LicensePoster Presentations:Emerging/Infectious Diseases3$E+DUYHVWLQJ &RQYDOHVFHQW 3ODVPD IRU +\SHULPPXQH        	  	        	         	              'RXEOH%OLQG&RQWUROOHG7ULDOIRU7UHDWPHQWRI3DWLHQWVZLWK    	                ! " # $ " # %&' " ( ) * # ' + , - . / 0 1 ! ( # / " ( % 2 " # ' 3 4 + &KHXN.ZRQJ/HHﬀ ./ " 6 % 7 * # ' 7 0 0ﬂ. 2 ( # ' % 2 " 9 " # .HQQ\&KDQ:DL0LQJ&KDQ .&KXQ:DL 1JDL . / ( # %  : 7 " ; ﬂ  )X/RL &KRZ< . = " ﬁ ? 4 # @ 7 ( *  ./ " # ' % 9 ( * 7 " ( A  &DQG\ &< /DX+ . B C " 4 % ) " 0 ( 7 ( * + D . / ; 4 E % ) * # '&KDQ+ &KH.LW/LQ- . / ; 4 E % 9 * # ' 9 * 0 # +ﬃG H I J K L M G N O P I N Q J IRO Q N S P T J O H O U V T W T X T J O J QRO Q N S P T J M X V T X N H X N X YZ M N N O [ H I \ ] J X ^ T P H K Y _ P H P N ` N \ a H b J I H P J I \ J Q c d N I e T O eRO Q N S P T J M XV T X N H X N X Y f g N h O T W N I X T P \ J Q ] J O e ` J O e Y ] J O e ` J O e Y i V N ^ H I P d N O PJ Q [ N U T S T O N Y Z M N N O [ H I \ ] J X ^ T P H K Y f g N h O T W N I X T P \ J Q ] J O e ` J O e Y] J O e ` J O e Y ] J O e ` J O e j N U G I J X XkK J J U f I H O X Q M X T J O _ N I W T S N Y] J O e ` J O e Y l V N ^ H I P d N O P J QRO P N O X T W N G H I N h O T P Y h O T P N U G g I T X P T H O] J X ^ T P H K Y ] J O e ` J O e Y m V N ^ H I P d N O P J QRO P N O X T W N G H I N h O T P YnH d N K HL J M U N o N P g N I X J K N c H X P N I O ] J X ^ T P H K Y ] J O e ` J O e Y p V N ^ H I P d N O PRI$QDHVWKHVLD DQG ,QWHQVLYH&DUH8QLW4XHHQ0DU\+RVSLWDO] J O e ` J O e Y q V N ^ H I P d N O P J Q [ N U T S T O N H O U r N I T H P I T S X YRO P N O X T W NG H I N h O T P Y G H I T P H X [ N U T S H K G N O P I N Y ] J O e ` J O e YsV N ^ H I P d N O P J Q[ N U T S T O N YjM P P J O t N N ] J X ^ T P H K H O U f H O e _ g T M ` T O ] J X ^ T P H K X Y ] J O e` J O e Y V N ^ H I P d N O P J QRO P N O X T W N G H I N [ N U T S T O N Y Z M N N O c K T u H b N P g] J X ^ T P H K Y ] J O e ` J O e Yﬃ vV N ^ H I P d N O P J QRO Q N S P T J O Y c d N I e N O S \ w&RQWLQJHQF\+RVSLWDO$XWKRULW\+RQJ.RQJx   y z   	    ([SHULHQFH IURP LQÀXHQ]DSDQGHPLFV VXJJHVWHGWKDWFRQYDOHVFHQWSODVPD WUHDWPHQWJLYHQZLWKLQ WRGD\VRIV\PSWRPRQVHWPLJKWEHEHQH¿FLDO +RZHYHUUREXVW WUHDWPHQW@ " { " ( | 1 " } E ( # ' ~   3 C ( | ( | " ? * 1 { ( } 0 # { 6 0 : 6 4 | : 0 } { ( ! 0 @ 4 *  1 0 %  1 ( # @UDQGRPL]HGFRQWUROOHG WULDO&RQYDOHVFHQWSODVPD IURPSDWLHQWVZKR UHFRYHUHG IURP WKH  SDQGHPLF LQÀXHQ]D >$+1SGP@ LQIHFWLRQZDV IUDFWLRQDWHG WR K\SHULPPXQH LQWUDYHQRXVLPPXQRJOREXOLQ+,9,*E\&6/%LRWKHUDSLHV$XVWUDOLD3DWLHQWV; ( { C | 0 ! 0 6 0   ) &  : @ ?   ( #  0 } { ( 4 # 4 # | { " # @ " 6 @ " # { ( ! ( 6 " 1{ 6 0 " { ? 0 # { 6 0  * ( 6 ( # ' ( # { 0 # | ( ! 0 } " 6 0 " # @ ! 0 # { ( 1 " { 4 6 ﬁ | * : : 4 6 { ; 0 6 0UDQGRPL]HG WR UHFHLYH +,9,* RU QRUPDO ,9,* PDQXIDFWXUHGEHIRUH  DV FRQWURO &OLQLFDO RXWFRPH DQG DGYHUVH HIIHFWV; 0 6 0 } 4 ? : " 6 0 @ ~ 	    %HWZHHQ  DQG  WKLUW\¿YH SDWLHQWV ZHUHUDQGRPL]HGWRUHFHLYH+,9,*SDWLHQWVRU,9,*SDWLHQWV # 0 @ 0  " * 1 { 0 @ : " { ( 0 # { ; " | 0  } 1 * @ 0 @  6 4 ? " # " 1 ﬁ | ( | ~&4 " @ ! 0 6 | 00 ! 0 # { 6 0 1 " { 0 @ { 4 { 6 0 " { ? 0 # { ; " | 6 0 : 4 6 { 0 @ ~  " | 0 1 ( # 0 @ 0 ? 4 ' 6 " : C ( } |" # @ ! ( 6 " 1 1 4 " @  0  4 6 0 { 6 0 " { ? 0 # { ; 0 6 0 | ( ? ( 1 " 6  0 { ; 0 0 # { C 0 { ; 4' 6 4 * : | ~ B 0 6 ( " 1 6 0 | : ( 6 " { 4 6 ﬁ ! ( 6 " 1 1 4 " @ @ 0 ? 4 # | { 6 " { 0 @ { C " { ) %    WUHDWPHQW ZDV DVVRFLDWHG ZLWK VLJQL¿FDQWO\ ORZHU GD\  DQG SRVWWUHDWPHQWYLUDO ORDGZKHQFRPSDUHGWR WKHFRQWURO S DQG S  UHVSHFWLYHO\ 7KH LQLWLDO VHUXP F\WRNLQH OHYHO ZDVVLJQL¿FDQWO\KLJKHULQWKH+,9,*JURXSEXWIHOOWRVLPLODUOHYHO@ " ﬁ | "  { 0 6 { 6 0 " { ? 0 # { ~ B *  ' 6 4 * : ? * 1 { ( ! " 6 ( " { 0 " # " 1 ﬁ | ( | 4  { C 0  SDWLHQWVZKRUHFHLYHGWUHDWPHQWZLWKLQGD\VRIV\PSWRPRQVHW@ 0 ? 4 # | { 6 " { 0 @ { C " { ) %     { 6 0 " { ? 0 # { ; " | { C 0 4 # 1 ﬁ  " } { 4 6 ; C ( } CLQGHSHQGHQWO\ UHGXFHG PRUWDOLW\ >25  &, S @&RQFOXVLRQV 3 6 0 " { ? 0 # { 4  | 0 ! 0 6 0   )  &   : @ ?   ( #  0 } { ( 4 # ; ( { C+,9,*ZLWKLQ  GD\VRI V\PSWRPRQVHWZDVDVVRFLDWHGZLWK D1 4 ; 0 6 ! ( 6 " 1 1 4 " @ " # @ 6 0 @ * } 0 @ ? 4 6 { " 1 ( { ﬁ ~jN Q  o J   G _3$E,Q6LOLFR6WUXFWXUHEDVHG6FUHHQLQJDQG&KDUDFWHUL]DWLRQRI,QKLELWRUVIRU,QÀXHQ]D$9LUXV1XFOHRSURWHLQ&KXQ<HXQJ/R+ .  ( # ' 7 ( * + . 7 ( { %  " #  4 4 # - 3DQJ&KXL6KDZ+ﬃG N O P I N Q J InI J P N T O _ S T N O S N H O U G I \ X P H K K J e I H ^ g \ Y _ S g J J K J Q a T Q N_ S T N O S N X Y f g N G g T O N X N h O T W N I X T P \ J Q ] J O e ` J O e Y ] J O e ` J O e Yi &HQWUHRI,QÀXHQ]D5HVHDUFKDQG6FKRRORI3XEOLF+HDOWK7KHh O T W N I X T P \ J Q ] J O e ` J O e Y ] J O e ` J O e3 C 0 { 6 0 # @ 4  @ 6 * ' 6 0 | ( | { " # } 0 @ 0 ! 0 1 4 : 0 @ ( # @ (   0 6 0 # { | { 6 " ( # | 4 LQÀXHQ]D YLUXVHV LV ZRUU\LQJ DQG LW LV RI XWPRVW LPSRUWDQFH" # @ * 6 ' 0 # } ﬁ { 4 @ 0 ! 0 1 4 : # 0 ; @ 6 * ' | " ' " ( # | { { C ( | ! ( 6 * | ~ 3 C 0 ! ( 6 " 1# * } 1 0 4 : 6 4 { 0 ( # &  ( | " ? "  4 6 } 4 ? : 4 # 0 # { 4  { C 0 6 (  4 # * } 1 0 4 : 6 4 { 0 ( # =&  } 4 ? : 1 0   4 6 { C 0 { 6 " # | } 6 ( : { ( 4 # " # @ 6 0 : 1 ( } " { ( 4 # 4  { C 0 ! ( 6 * | ~ # 4 6 @ 0 6 { 4 ? " ( # { " ( # " | { "  1 0 =& | { 6 * } { * 6 0 .&  4 6 ? | C 4 ? 4 %4 1 ( ' 4 ? 0 6 |  ﬁ ( # | 0 6 { ( # ' ( { | { " ( 1 % 1 4 4 : { 4 { C 0 { " ( 1 % 1 4 4 : ( # | 0 6 { ( 4 # | ( { 04  " # 4 { C 0 6& ~  # { C ( | | { * @ ﬁ . ; 0 C " ! 0 0 ? : 1 4 ﬁ 0 @ | { 6 * } { * 6 0 %  " | 0 @YLUWXDO VFUHHQLQJ RQ WKH LQÀXHQ]D $ 13 WDLO ORRS LQVHUWLRQVLWH DQG IRXQG WZR KLW FRPSRXQGV QXPEHU  DQG  WKDW FDQVXEGXH LQÀXHQ]D 513 DFWLYLWLHV  6XEVHTXHQWO\ WZR DQDORJVIURP FRPSRXQG  ZHUH LGHQWL¿HG ZKLFK LQKLELW 513 DFWLYLWLHVRI YDULRXV LQÀXHQ]D$ VXEW\SHV DQG YLUDO JURZWK DWPLFURPRODU1 0 ! 0 1 | ~ 3 C 0 | 0 " # " 1 4 ' | ; 0 6 0 " 1 | 4 | C 4 ; # { 4 @ ( 6 0 } { 1 ﬁ ( # { 0 6 " } { ; ( { C&DWDQGȝ0UHVSHFWLYHO\E\VXUIDFHSODVPRQUHVRQDQFHDVVD\7KHVHQRYHODQWLLQÀXHQ]DFRPSRXQGVZRXOG: 6 4 ! ( @ 0 " { 0 ? : 1 " { 0  4 6 @ 0 | ( ' # ( # ' @ 6 * ' } " # @ ( @ " { 0 | ; ( { C C ( ' C 0 6: 4 { 0 # } ﬁ ~5HI1R3$E      z   	      	                y        z        	       z    z  	    z    Ł    WKH+XPDQ6ZLQH,QÀXHQ]D$+19LUXVLQ 4 | 0 : C 2 * + .  # @ 6 0 ; ) 4 + .  @ ; " 6 @  " +  &KHXN .ZRQJ /HH- .'DQLHO &KX+ .  4 7 " ( ) 4 + .  ! " # ) * # ' + . 7 " (  ( # ' ) 4 +  &KH .LW7 ( #-. 3 C 4 ? " | 3 | " # 'ﬀ. B *  * ( 7 4ﬂ. 9 * 7 * # ' 7 " *+.  "  6 ( 0 1 7 0 * # '+.%HQMDPLQ&RZOLQJ+ .  " 1 ( E  0 ( 6 ( | +ﬃf g N h O T W N I X T P \ J Q ] J O e ` J O e Y ] J O e ` J O e Y ijN U G I J X XkK J J Uf I H O X Q M X T J O _ N I W T S N X Y ] J O e ` J O e Y  G N O P I N Q J I ] N H K P g n I J P N S P T J O Y] J O e ` J O e Y ] J O e ` J O e Y l +RVSLWDO$XWKRULW\+RQJ.RQJx   y z   	     ,Q DQ HPHUJLQJ LQÀXHQ]D SDQGHPLF HVWLPDWLQJ| 0 ! 0 6 ( { ﬁ  { C 0 : 6 4  "  ( 1 ( { ﬁ 4  " | 0 ! 0 6 0 4 * { } 4 ? 0 . | * } C " |KRVSLWDOL]DWLRQ LI LQIHFWHG LV D SXEOLF KHDOWK SULRULW\ $V PDQ\LQÀXHQ]D LQIHFWLRQVDUH VXEFOLQLFDO VHURVXUYHLOODQFH LV QHHGHG{ 4 " 1 1 4 ; 6 0 1 ( "  1 0 6 0 " 1 % { ( ? 0 0 | { ( ? " { 0 | 4  ( #  0 } { ( 4 # " { { " } E 6 " { 0    = " # @ | 0 ! 0 6 ( { ﬁ ~       	    :H WHVWHG  VHUD FROOHFWHGGXULQJWKH¿UVWZDYHRIWKHSDQGHPLFLQ+RQJ.RQJXVLQJYLUDO PLFURQHXWUDOL]DWLRQ :H HVWLPDWHG ,$5 DQG LQIHFWLRQKRVSLWDOL]DWLRQ SUREDELOLW\ ,+3 IURP WKH VHULDO FURVVVHFWLRQDOVHURORJLFGDWDDQGKRVSLWDOL]DWLRQGDWD+DGRXU VHURORJLFGDWD 0 0 # " ! " ( 1 "  1 0 ; 0 0 E 1 ﬁ ( # 6 0 " 1 { ( ? 0 . ; 0 ; 4 * 1 @ C " ! 0 4  { " ( # 0 @6 0 1 ( "  1 0  )  0 | { ( ? " { 0 |  ; E "  { 0 6 .  %  ; E  0  4 6 0 . " # @  ; E "  { 0 6HSLGHPLFSHDNIRULQGLYLGXDOVDJHG\\DQG\3 C 0 6 " { ( 4 4    = { 4 : 6 0 % 0  ( | { ( # ' | 0 6 4 : 6 0 ! " 1 0 # } 0 . ; C ( } C @ 0 } 6 0 " | 0 @; ( { C " ' 0 . ; " | " ? "  4 6 @ 0 { 0 6 ? ( # " # {  4 6 { C 0 { ( ? 0 1 ( # 0 | | 4  6 0 1 ( "  1 00 | { ( ? " { 0 | ~   ; 0  0 ' " # | 0 6 4 % | * 6 ! 0 ( 1 1 " # } 0  ; E "  { 0 6 } 4 ? ? * # ( { ﬁWUDQVPLVVLRQZDVFRQ¿UPHGZLWKDQGVSHFLPHQVSHU ZHHN IRU LQGLYLGXDOV DJHG  \  \ DQG  \6 0 | : 0 } { ( ! 0 1 ﬁ . ; 0 ; 4 * 1 @ C " ! 0 4  { " ( # 0 @ 6 0 1 ( "  1 0  )  0 | { ( ? " { 0 |  4 6WKHVHDJHJURXSVZNEHIRUHWKHSHDN)RU\ROGVHYHQ VSHFLPHQV SHU ZHHN ZRXOG QRW KDYH JHQHUDWHG UHOLDEOH0 | { ( ? " { 0 | * # { ( 1 { C 0 : 0 " E  0 } " * | 0 { C 0 6 " { ( 4 4    = { 4 : 6 0 % 0  ( | { ( # 'Abstracts of Poster Presentations: Emerging / Infectious Diseases

Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentre randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection

http://hub.hku.hk/bitstream/10722/217535/1/Abstract.pdf

Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentre randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection

Abstract

Similar works

Full text

Available Versions

HKU Scholars Hub