Imaging violence in schizophrenia: A systematic review and critical discussion of the MRI literature

Background: Persons with schizophrenia have a small but significant increase in risk of violence, which remains after controlling for known environmental risk factors. In vivo MRI-studies may point toward the biological underpinnings of psychotic violence, and neuroimaging has increasingly been used in forensic and legal settings despite unclear relevance. Objectives: (1) To present the first systematic review, following standardized guidelines, of MRI studies of violence with schizophrenia. (2) To critically discuss the promises and pitfalls of using this literature to understand violence in schizophrenia in clinical, forensic, and legal settings. Methods: Following the PRISMA guidelines and literature searches until January 2018, we found 21 original studies that fulfilled the inclusion criteria: (1) Studies of persons with schizophrenia, (2) a history of violence or aggressive behavior, (3) the use of one or more MRI-modalities (sMRI, DTI, fMRI). Results: The most consistent findings from the structural studies were reduced volumes of the hippocampus and the frontal lobe (in particular the orbitofrontal and anterior cingulate cortex) in schizophrenia patients with a history of violence or higher aggression scores. The functional studies mainly showed differences and aggression correlates in the frontal lobe and amygdala. However, the studies were methodologically heterogeneous, with four particular areas of concern: different definitions of violence, region of interest vs. whole-brain studies, small subject samples, and group comparisons in a heterogeneous diagnostic category (schizophrenia). Conclusion: The literature reports subtle, but inconsistent group level differences in brain structure and function associated with violence and aggression with schizophrenia, in particular in areas involved in the formation of psychosis symptoms and affective regulation. Due to methodological challenges the results should be interpreted with caution. In order to come closer to the neurobiological underpinnings of violence in schizophrenia future studies could: (1) address the neurobiological differences of premeditated and reactive violence, (2) use RDoC criteria, for example, or other symptom-based systems to categorize psychosis patients, (3) increase subject cohorts and apply new data driven methods. In this perspective, MRI-studies of violence in schizophrenia have the potential to inform clinical violence prediction and legal evaluations in the future

Avaliação cefalométrica radiográfica da posição craniocervical de pacientes orientados em posição natural da cabeça pré e pós-expansão rápida da maxila Cephalometric radiographic evaluation of the craniocervical position of patients oriented in natural head position before and after the rapid maxillary expansion

O objetivo deste estudo foi avaliar a eventual alteração na posição craniocervical de pacientes orientados na Posição Natural da Cabeça (PNC), após o procedimento de expansão rápida da maxila (ERM). Utilizaram-se telerradiografias em norma lateral, selecionadas do acervo de documentação da Clínica de Ortodontia Preventiva da Faculdade de Odontologia da Universidade de São Paulo, de 20 pacientes, com idades entre 5 a 11 anos (média de 9,0 anos), sendo 7 do gênero masculino e 13 do feminino, obtidas no início do tratamento e imediatamente após a fase ativa da expansão da maxila. Os pacientes eram portadores de atresia da maxila e foram tratados com aparelho disjuntor tipo Biederman modificado. A partir dos cefalogramas pré e pós-ERM foram obtidas as grandezas angulares craniovertical (SN.VER), craniocervical (OPT.SN e CVT.SN), cervicohorizontal (OPT.HOR, CVT.HOR) e o ângulo da curvatura cervical (OPT.CVT). Após análise estatística e interpretação dos resultados obtidos concluímos que a posição da cabeça não apresentou alteração estatisticamente significativa. Não foram observadas diferenças estatisticamente significativas entre os gêneros quando comparadas as fases pré e pós-ERM para as grandezas estudadas. O método de obtenção de telerradiografias laterais em Orientação Natural da Cabeça mostrou-se confiável e reproduzível na amostra estudada, mesmo na presença de intervenção ortodôntica-ortopédica entre as séries de radiografias.<br>The aim of this study was to evaluate the eventual alteration in the craniocervical position of patients, oriented in the Natural Head Position (NHP), after the rapid maxillary expansion (RME) procedure. We have used lateral radiographs, selected from the documentation file of the Preventive Orthodontics Clinic, School of Dentistry, University of São Paulo. Our sample consisted of 20 patients (7M:13F), with ages ranging from 5.08 up to 11.08 years (mean of 9,0). The cephalometric radiographs were obtained in the beginning of the treatment and immediately after the active phase of the maxilla expansion. All patients showed constrictions of the maxilla, and were treated with modified Biederman appliance. Craniocervical cephalometric analysis was carried out by evaluating the craniovertical (SN.VER), craniocervical (OPT.SN e CVT.SN), cervicohorizontal (OPT.HOR e CVT.HOR) and the cervical curve (OPT. CVT) angles. On the basis of the statistical analysis of the data, we conclude that the head position did not show significant alteration. Statistically significant differences were not detected between the sexes, when the phases pre and post RME were compared for the measurements studied. In the sample studied, the method of obtaining cephalometric radiographs in the Natural Head Orientation showed to be trustworthy and reproducible, even in the presence of orthodontic-orthopedic intervention between the series of radiographs