26 research outputs found
Development and validation of a model to predict the 10-year risk of general practitioner-recorded COPD
There is increasing interest in the earlier detection of, and intervention in, patients at highest risk of developing chronic obstructive pulmonary disease (COPD).status: publishe
The human keratins: biology and pathology
The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed in highly specific patterns related to the epithelial type and stage of cellular differentiation. About half of all keratins—including numerous keratins characterized only recently—are restricted to the various compartments of hair follicles. As part of the epithelial cytoskeleton, keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Moreover, some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. Applying the new consensus nomenclature, this article summarizes, for all human keratins, their cell type and tissue distribution and their functional significance in relation to transgenic mouse models and human hereditary keratin diseases. Furthermore, since keratins also exhibit characteristic expression patterns in human tumors, several of them (notably K5, K7, K8/K18, K19, and K20) have great importance in immunohistochemical tumor diagnosis of carcinomas, in particular of unclear metastases and in precise classification and subtyping. Future research might open further fields of clinical application for this remarkable protein family
A randomized trial of Plasma-Lyte A and 0.9 % sodium chloride in acute pediatric gastroenteritis
What is a good health check? An interview study of health check providers’ views and practices
Geological Processes and Hydrothermal Mineralisation in Plate Tectonic Settings — Mineral Exploration
Lernen und Gedächtnis im Alter
Lernen und Gedächtnis sind zentrale Voraussetzungen für menschliches Erleben, Verhalten, Identität und Persönlichkeit. Wir sind somit das Produkt aus unseren Lernerfahrungen und unseren Erinnerungen. Aus diesem Grund ist für viele Menschen der Erhalt der Lernfähigkeit und des Gedächtnisses bis ins hohe Alter von großer Relevanz. Um Lernen und Gedächtnis im Alter besser verstehen zu können, ist es wichtig zu wissen, wie sie sich über die Lebensspanne verändern und wie stark sie miteinander zusammenhängen. Deshalb werden im Folgenden zuerst diese zwei Konzepte in Bezug zueinander gesetzt und danach unabhängig voneinander genauer erläutert. Abschließend werden aus den Befunden resultierende Interventionsmöglichkeiten aufgezeigt und die wichtigsten Erkenntnisse kurz zusammengefasst