Crisis (Hostage) Negotiations

This multidisciplinary volume assembles current findings on violent crime, behavioral, biological, and sociological perspectives on its causes, and effective methods of intervention and prevention. Noted experts across diverse fields apply a behavioral criminology lens to examine crimes committed by minors, extremely violent offenses, sexual offending, violence in families, violence in high-risk settings, and crimes of recent and emerging interest. The work of mental health practitioners and researchers is shown informing law enforcement response to crime in interrogation, investigative analysis, hostage negotiations, and other core strategies. In addition, chapters pay special attention to criminal activities that violate traditional geographic boundaries, from cyberstalking to sex trafficking to international terrorism. Among the topics in the Handbook: Dyadic conceptualization, measurement, and analysis of family violence. School bullying and cyberbullying: prevalence, characteristics, outcomes, and prevention. A cultural and psychological perspective on mass murder. Young people displaying problematic sexual behavior: the research and their words. Child physical abuse and neglect. Criminal interviewing and interrogation in serious crime investigations. Violence in correctional settings. Foundations of threat assessment and management. The Handbook of Behavioral Criminology is a meticulous resource for researchers in criminology, psychology, sociology, and related fields. It also informs developers of crime prevention programs and practitioners assessing and intervening with criminal clients and in correctional facilities.https://nsuworks.nova.edu/cps_facbooks/1561/thumbnail.jp

Overview and Introduction

Americans are no strangers to crime. As a country we are privy to stories of criminal acts on a daily, even hourly, basis through our constant connection to information via television, radio, print, and the Internet. In recent decades the ability to gain real-time information about local, state, and national crime has further revealed the alarming reality of crime in this country. Our daily lives are seemingly enmeshed with violence in today’s media, and questions arise how this perpetual exposure impacts our society. In 1950, only 10% of American households owned a television, but today televisions are present in 99% of homes. Television programs display over 800 violent acts in a single hour (Beresin, 2009). According to a 2014 Gallup Poll, 70% of Americans believed crime had gone up in the past year (Gallup, 2015), inconsistent with federal crime reports.https://nsuworks.nova.edu/cps_facbooks/1579/thumbnail.jp

Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer

The treatment of patients with ovarian cancer is rapidly changing following the success of poly [ADP-ribose] polymerase (PARP) inhibitors in clinical trials. Olaparib is the first PARP inhibitor to be approved by the EMA and FDA for BRCA-mutated ovarian cancer. Germ line BRCA mutation status is now established as a predictive biomarker of potential benefit from treatment with a PARP inhibitor; therefore, knowledge of the BRCA status of an individual patient with ovarian cancer is essential, in order to guide treatment decisions. BRCA testing was previously offered only to women with a family or personal history of breast and/or ovarian cancer; however, almost 20% of women with high-grade serous ovarian cancer are now recognized to harbour a germ line BRCA mutation, and of these, >40% might not have a family history of cancer and would not have received BRCA testing. A strategy to enable more widespread implementation of BRCA testing in routine care is, therefore, necessary. In this Review, we summarize data from key clinical trials of PARP inhibitors and discuss how to integrate these agents into the current treatment landscape of ovarian cancer. The validity of germ line BRCA testing and other promising biomarkers of homologous-recombination deficiency will also be discussed