Contents

The Investment Company Institute (ICI) is the national association of U.S. investment companies. ICI seeks to encourage adherence to high ethical standards, promote public understanding, an

Oaths and Incidental Matters Inferior Courts Initial Review of and Action on Records of Trial Ordering Rehearings-Designating

Th?rc jx~phlet contains a short history of the preparation 0: ' +.he Manual for Courts-Martial, United States, 1951, %%other with brief discussions of the legal and legislative;onsiderations involved in the drafting of the book. With &nor exceptions, the discussions of the various subjects were written by the officers who prepared the initial drafts of the comparable portions of the manual

Improving the management of multimorbidity in general practice:protocol of a cluster randomised controlled trial (The 3D Study)

<B>INTRODUCTION</B> An increasing number of people are living with multimorbidity. The evidence base for how best to manage these patients is weak. Current clinical guidelines generally focus on single conditions, which may not reflect the needs of patients with multimorbidity. The aim of the 3D study is to develop, implement and evaluate an intervention to improve the management of patients with multimorbidity in general practice. <B>METHODS AND ANALYSIS</B> This is a pragmatic two-arm cluster randomised controlled trial. 32 general practices around Bristol, Greater Manchester and Glasgow will be randomised to receive either the ‘3D intervention’ or usual care. 3D is a complex intervention including components affecting practice organisation, the conduct of patient reviews, integration with secondary care and measures to promote change in practice organisation. Changes include improving continuity of care and replacing reviews of each disease with patient-centred reviews with a focus on patients' quality of life, mental health and polypharmacy. We aim to recruit 1383 patients who have 3 or more chronic conditions. This provides 90% power at 5% significance level to detect an effect size of 0.27 SDs in the primary outcome, which is health-related quality of life at 15 months using the EQ-5D-5L. Secondary outcome measures assess patient centredness, illness burden and treatment burden. The primary analysis will be a multilevel regression model adjusted for baseline, stratification/minimisation, clustering and important co-variables. Nested process evaluation will assess implementation, mechanisms of effectiveness and interaction of the intervention with local context. Economic analysis of cost-consequences and cost-effectiveness will be based on quality-adjusted life years. <B>ETHICS AND DISSEMINATION</B> This study has approval from South-West (Frenchay) National Health Service (NHS) Research Ethics Committee (14/SW/0011). Findings will be disseminated via final report, peer-reviewed publications and guidance to healthcare professionals, commissioners and policymakers

Active PETs: Active Data Annotation Prioritisation for Few-Shot Claim Verification with Pattern Exploiting Training

To mitigate the impact of the scarcity of labelled data on fact-checking systems, we focus on few-shot claim verification. Despite recent work on few-shot classification by proposing advanced language models, there is a dearth of research in data annotation prioritisation that improves the selection of the few shots to be labelled for optimal model performance. We propose Active PETs, a novel weighted approach that utilises an ensemble of Pattern Exploiting Training (PET) models based on various language models, to actively select unlabelled data as candidates for annotation. Using Active PETs for few-shot data selection shows consistent improvement over the baseline methods, on two technical fact-checking datasets and using six different pretrained language models. We show further improvement with Active PETs-o, which further integrates an oversampling strategy. Our approach enables effective selection of instances to be labelled where unlabelled data is abundant but resources for labelling are limited, leading to consistently improved few-shot claim verification performance

Clinical and urodynamic findings in women affected by mixed urinary incontinence

The definition of mixed urinary incontinence (MUI) of the International Continence Society exclusively assesses patient-reported symptoms without consideration of physical and urodynamic results, what is inadequate to reliably predict the pathophysiology of the underlying pathology. We investigated and compared clinical and urodynamic findings in women with MUI and assessed predictive variables for the different MUI clinical presentations