PHARMACOTHERAPY OF SEVERE ASTHMA IN CHILDREN: A NOTE ON INHALED CORTICOSTEROIDS

Article is devoted to the treatment of bronchial asthma in children according to age, form and severity of the disease. An analysis of published randomized trials for the treatment of severe asthma in young children has been carried out, the complexity of the treatment of patients at this age has been demonstrated. Particular attention is focused on the authors evaluate the effectiveness and safety of inhaled corticosteroids that are used as monotherapy or in combination with other groups of drugs in children of different age groups depending on the severity of asthma. The conditions for improving adherence to therapy are discussed. Key words: asthma, treatment, inhaled corticosteroids, the efficacy, safety, adherence to therapy, dry powder inhaler, metered dose aerosol inhaler, children. (Pediatric pharmacology. — 2011; 8 (6): 40–48)

ACTIVATED ZINC PYRITHIONE APPLICATION FOR THE ATOPIC DERMATITIS AMONG CHILDREN: MECHANISM OF ACTION, CLINICAL EFFICIENCY

Atopic dermatitis is characterized by the chronic recurrent course and often complicated by the consecutive infection and requires an adequate and regular external treatment. This article is devoted to the overview of the key pharmacodynamic and clinical effects of the activated zinc pyrithione for the atopic dermatitis. The activated zinc pyrithione has an expressed, antiinflammatory, proapoptogenic, antifungal and antibacterial effect, owing to which it affects all the components of the atopic dermatitis pathogenesis. The research with nessed the high efficiency and safety of this medication for atopic dermatitis in children, which allows the researchers to classify it as the efficient non steroid medications for the external treatment for the atopic dermatitis among children.Key words: atopic dermatitis, treatment, activated zinc pyrithione, children

PHARMACOTHERAPY OF SEVERE ASTHMA IN CHILDREN: A NOTE ON INHALED CORTICOSTEROIDS

Article is devoted to the treatment of bronchial asthma in children according to age, form and severity of the disease. An analysis of published randomized trials for the treatment of severe asthma in young children has been carried out, the complexity of the treatment of patients at this age has been demonstrated. Particular attention is focused on the authors evaluate the effectiveness and safety of inhaled corticosteroids that are used as monotherapy or in combination with other groups of drugs in children of different age groups depending on the severity of asthma. The conditions for improving adherence to therapy are discussed. Key words: asthma, treatment, inhaled corticosteroids, the efficacy, safety, adherence to therapy, dry powder inhaler, metered dose aerosol inhaler, children. (Pediatric pharmacology. — 2011; 8 (6): 40–48)

ACTIVATED ZINC PYRITHIONE APPLICATION FOR THE ATOPIC DERMATITIS AMONG CHILDREN: MECHANISM OF ACTION, CLINICAL EFFICIENCY

Atopic dermatitis is characterized by the chronic recurrent course and often complicated by the consecutive infection and requires an adequate and regular external treatment. This article is devoted to the overview of the key pharmacodynamic and clinical effects of the activated zinc pyrithione for the atopic dermatitis. The activated zinc pyrithione has an expressed, antiinflammatory, proapoptogenic, antifungal and antibacterial effect, owing to which it affects all the components of the atopic dermatitis pathogenesis. The research with nessed the high efficiency and safety of this medication for atopic dermatitis in children, which allows the researchers to classify it as the efficient non steroid medications for the external treatment for the atopic dermatitis among children.Key words: atopic dermatitis, treatment, activated zinc pyrithione, children

АКТИВИРОВАННЫЙ ЦИНКА ПИРИТИОН ПРИ АТОПИЧЕСКОМ ДЕРМАТИТЕ У ДЕТЕЙ. МЕХАНИЗМ ДЕЙСТВИЯ, КЛИНИЧЕСКАЯ ЭФФЕКТИВНОСТЬ

Atopic dermatitis is characterized by the chronic recurrent course and often complicated by the consecutive infection and requires an adequate and regular external treatment. This article is devoted to the overview of the key pharmacodynamic and clinical effects of the activated zinc pyrithione for the atopic dermatitis. The activated zinc pyrithione has an expressed, antiinflammatory, proapoptogenic, antifungal and antibacterial effect, owing to which it affects all the components of the atopic dermatitis pathogenesis. The research with nessed the high efficiency and safety of this medication for atopic dermatitis in children, which allows the researchers to classify it as the efficient non steroid medications for the external treatment for the atopic dermatitis among children.Key words: atopic dermatitis, treatment, activated zinc pyrithione, children.Атопический дерматит имеет хроническое рецидивирующее течение, часто осложняется вторичной инфекцией и требует адекватной и постоянной наружной терапии. Данная статья посвящена обзору основных фармакодинамических и клинических эффектов активированного пиритиона цинка при атопическом дерматите (АтД). Активированный пиритион цинка обладает выраженным противовоспалительным, проапоптогенным, противогрибковым и антимикотическим действием, благодаря чему воздействует на все компоненты патогенеза АтД. Проведенные исследования свидетельствуют о высокой эффективности и безопасности этого препарата при АтД у детей, что позволяет отнести его к эффективным нестероидным средствам для наружной терапии АтД у детей. Ключевые слова: атопический дерматит, лечение, активированный пиритион цинка, дети. (Педиатрическая фармакология. – 2009;6(2):67-71

CLINICAL EFFICIENCY OF ZINC PYRITHIONE TO TREAT ATOPIC DERMATITIS IN CHILDREN

Atopic dermatitis is one of the most widespread children’s diseases, it has a chronic recurrent clinical course, may be often complicated with the secondary infection. This necessitates the choice of a medication to impact all stages of the disease process with a high safety profile. This digest is devoted to activated zinc pyrithione. Overall, currently available data make it possible to state that this agent is one of the most effective and safest products to be used for a local therapy of atopic dermatitis in children. Key words: atopic dermatitis, activated zinc pyrithione, childre

CLINICAL EFFICIENCY OF ZINC PYRITHIONE TO TREAT ATOPIC DERMATITIS IN CHILDREN

Atopic dermatitis is one of the most widespread children’s diseases, it has a chronic recurrent clinical course, may be often complicated with the secondary infection. This necessitates the choice of a medication to impact all stages of the disease process with a high safety profile. This digest is devoted to activated zinc pyrithione. Overall, currently available data make it possible to state that this agent is one of the most effective and safest products to be used for a local therapy of atopic dermatitis in children. Key words: atopic dermatitis, activated zinc pyrithione, childre

КЛИНИЧЕСКАЯ ЭФФЕКТИВНОСТЬ И АНТИМИКРОБНАЯ АКТИВНОСТЬ ПИРИТИОНА ЦИНКА ПРИ АТОПИЧЕСКОМ ДЕРМАТИТЕ У ДЕТЕЙ

Atopic dermatitis is one of the most widespread children’s diseases, it has a chronic recurrent clinical course, may be often complicated with the secondary infection. This necessitates the choice of a medication to impact all stages of the disease process with a high safety profile. This digest is devoted to activated zinc pyrithione. Overall, currently available data make it possible to state that this agent is one of the most effective and safest products to be used for a local therapy of atopic dermatitis in children. Key words: atopic dermatitis, activated zinc pyrithione, childrenАтопический дерматит является одним из наиболее распространенных заболеваний в детской популяции, имеет хроническое рецидивирующее течение, часто осложняется вторичной инфекцией. Это диктует необходимость выбора препарата, воздействующего на все звенья патогенеза заболевания, и имеющего высокий профиль безопасности. Данная обзорная статья посвящена активированному пиритиону цинка (АПЦ). В целом, имеющиеся в настоящее время данные позволяют говорить об этом средстве, как об одном из наиболее эффективных и безопасных в ряду использующихся для местной терапии атопического дерматита у детей. Ключевые слова: атопический дерматит, активированный пиритион цинка, дети. (Педиатрическая фармакология. – 2009; 6(1):64-69)