110 research outputs found

    Axon swellings produced in vivo in isolated segments of nerves

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    Within 3–5 hrs after cutting rat and cat sciatic nerves into segments which had no connection with the cell body, club-shaped axon swellings were observed at both ends of the segments. The swollen portion of these axons showed increased histochemical reactions for DPN-diaphorase, lactic dehydrogenase, malic dehydrogenase, succinic dehydrogenase, and protein; the increase lasted for 24–48 hrs after the nerve was cut. The swollen axons were morphologically and histochemically similar to, but never as markedly changed, as those observed in the proximal stumps of severed nerves. The development of axon swellings was prevented by depolarization of the entire segment with KCl; however, if KCl was applied selectively to the stumps of the segment, it appeared to intensify rather than prevent the swelling. It was also noted that the extent of axon swelling was inversely proportional to the length of the segment. These observations suggested that the development and extent of axon swelling was related to the intensity of local injury currents in the tissue. Innerhalb von 3–5 Std nach Zerschneidung des Nervus ischiadicus von Ratten und Katzen in Segmente, die keine Verbindung mit dem Zellkörper besitzen, sind zylinderförmige Axonschwellungen an beiden Enden der Segmente zu beobachten. Der angeschwollene Teil dieser Axone zeigt verstärkte histochemische Reaktionen auf DPN-Diaphorase, Milchsäure-Dehydrogenase, Apfelsäure-Dehydrogenase, Bernsteinsäure-Dehydrogenase und Protein; dieser Anstieg hält 24–48 Std nach der Durchtrennung des Nervs an. Die Axonschwellungen sind sowohl morphologisch als auch histochemisch ähnlich — jedoch niemals in gleich starker Ausprägung — jenen, die in den proximalen Stümpfen von verletzten Nerven beobachtet werden.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47224/1/401_2004_Article_BF00684398.pd

    Clinical disorders affecting mesopic vision

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    Vision in the mesopic range is affected by a number of inherited and acquired clinical disorders. We review these conditions and summarize the historical background, describing the clinical characteristics alongside the genetic basis and molecular biological mechanisms giving rise to rod and cone dysfunction relevant to twilight vision. The current diagnostic gold standards for each disease are discussed and curative and symptomatic treatment strategies are summarized

    Trade blocs and trade wars during the interwar period

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    What precisely were the causes and consequences of the trade wars in the 1930s? Were there perhaps deeper forces at work in reorienting global trade prior to the outbreak of World War II? And what lessons may this particular historical episode provide for the present day? To answer these questions, we distinguish between long‐run secular trends in the period from 1920 to 1939 related to the formation of trade blocs and short‐run disruptions associated with the trade wars of the 1930s. We argue that the trade wars mainly served to intensify pre‐existing efforts toward the formation of trade blocs which dated from at least 1920. More speculatively, we argue that the trade wars of the present day may serve a similar purpose as those in the 1930s, that is, the intensification of China‐ and US‐centric trade blocs

    Neuropathologische Methoden und Ergebnisse bei Enzephalitiden

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