2 research outputs found
First-line treatment in lymphomatoid papulosis: a retrospective multicentre study.
Data regarding response to treatment in lymphomatoid papulosis (LyP) are scarce. To assess the daily clinical practice approach to LyP and the response to first-line treatments. This was a retrospective study enrolling 252 patients with LyP. Topical steroids, methotrexate and phototherapy were the most common first-line treatments, prescribed for 35%, 20% and 14% of the patients, respectively. Complete response (CR) was achieved in 48% of treated patients. Eczematous lesions significantly increased relative risk (RR) of not achieving CR (RRÂ =Â 1.76; 95% CI 1.16-2.11). Overall median time to CR was 10Â months (95% CI 6-13Â months), and 78% of complete responders showed cutaneous relapse; both results were similar for all treatment groups (PÂ >Â 0.05). Overall estimated median disease-free survival (DFS) was 11Â months (95% CI 9-13Â months) but DFS for patients treated with phototherapy was 23Â months (95% CI 10-36Â months; PÂ Â 0.05). Overall estimated median disease-free survival (DFS) was 11Â months (95% CI 9-13Â months) but DFS for patients treated with phototherapy was 23Â months (95% CI 10-36Â months; PÂ Current epidemiological, clinical and pathological data support previous results. Topical steroids, phototherapy and methotrexate are the most frequently prescribed first-line treatments. Although CR and cutaneous relapse rates do not differ between them, phototherapy achieves a longer DFS. Presence of Type A LyP and use of topical steroid or methotrexate were associated with an increased risk of early relapse