Experimental Intradermal Granuloma Formation**From the Department of Pathology, Beth Israel Hospital, Harvard Medical School, and the Division of Tumor Immunology, Children's Cancer Research Foundation, Boston, Massachusetts. (Reprint requeats to Dr. E. J. Kasdon, Department of Pathology, Beth Israel Hospital, 330 Brookline Avenue, Boston, Mass. 02215.)

Experimental induction of an intradermal granulomatous hypersensitivity reaction in the primarily immunized guinea pig was studied by means of tight microscopy during the course of the immune response. Animals were sensitized to dinitrophenylated human serum albumin (DNP10-HSA), and challenged with this antigen covalently linked to Sepharose 2B beads by the cyanogen bromide reaction. At appropriate intervals, the dermal changes produced by this complex antigen were compared with those produced by DNP10-HSA or soluble antigen. Sepharose 2B beads atone, and DNP10-HSA plus Sepharose 2B in the same animal. The complex antigen produced lesions characteristic of granulomatous hypersensitivity 5 and 11 days beyond the time of the skin test. The others showed the characteristic responses of hypersensitivity, foreign-body reaction, and a mixture of delayed-hypersensitivity and foreign-body reaction, but the intensity of the reactions had diminished by 5 days and had disappeared after 11 days. These results indicate that a dermal granulomatous hypersensitivity reaction may be differentiated from a foreign-body reaction. They also suggest that locally retained antigen interacts with sensitized lymphocytes to contribute to granuloma formation

Cognitive, Emotional, and Behavioral Responses of Injured Athletes

60 pagesTo date, there has been little empirical research to support the role that psychological intervention strategies con play in the rehabilitation of injured athletes. While the concept behind psychological intervention in rehabilitation is on intuitive one, the case for such strategies could be strengthened by scientific research which determines that injured athletes do in fact respond negatively to their injuries. Consequently, it it is the purpose of this study, based on the literature reviewed, to obtain descriptive data about the use or lack of use of negative coping strategies among injured athletes

Monovalent Ion Condensation at the Electrified Liquid/Liquid Interface

X-ray reflectivity studies demonstrate the condensation of a monovalent ion at the electrified interface between electrolyte solutions of water and 1,2-dichloroethane. Predictions of the ion distributions by standard Poisson-Boltzmann (Gouy-Chapman) theory are inconsistent with these data at higher applied interfacial electric potentials. Calculations from a Poisson-Boltzmann equation that incorporates a non-monotonic ion-specific potential of mean force are in good agreement with the data.Comment: 4 pages, 4 figure