Silicon resonant microcantilevers for absolute pressure measurement

This work is focused on the developing of silicon resonant microcantilevers for the measurement of the absolute pressure. The microcantilevers have been fabricated with a two-mask bulk micromachining process. The variation in resonance response of microcantilevers was investigated as a function of pressure 10−1-105 Pa, both in terms of resonance frequency and quality factor. A theoretical description of the resonating microstructure is given according to different molecular and viscous regimes. Also a brief discussion on the different quality factors contributions is presented. Theoretical and experimental data show a very satisfying agreement. The microstructure behavior demonstrates a certain sensitivity over a six decade range and the potential evolution of an absolute pressure sensor working in the same rang

Application of an ultra-wide band sensor-free wireless network for ground monitoring

Ground displacement monitoring is one of the most important aspects of early warning systems and risk management strategies when addressing phenomena such as landslides or subsidence. Several types of instrumentation already exist, but those able to provide real-time warnings on multiple time series are typically based on expensive technology, highlighting the need to develop a low-cost, easy to install system suitable for emergency monitoring. Therefore, a wireless network based on ultra-wideband impulse radiofrequency technology has been realized. The novelty of this network consists of its ability to measure the distance between nodes using the same signals used for transmission without the need for an actual measurement sensor. The system was tested by monitoring a mudflow in Central Italy and revealed its suitability as an early warning tool. More research on the integration of future low-cost hardware and and eventual industrialization would provide further improvement to this promising technology.Published1-142V. Struttura e sistema di alimentazione dei vulcani4V. Processi pre-eruttiviJCR Journa

Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort

Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment.</p

Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort

Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment. Analysis and support of clinical decision makin

Seasonal variation of anti-PD-1 outcome in melanoma-Results from a Dutch patient cohort

Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment

Exploiting the knowledge shared among the members of a virtual community: collaborative innovation processes in a global automotive company

The rising of Web 2.0 technologies is changing the traditional way companies search and interact on the web, enabling open knowledge sharing processes and collaborative innovation. This paper describes a methodology to consolidate a collaborative Innovation approach based on exploitation of knowledge shared on the web and active participation of customers within new product development process. We tested the methodology in a case of a global automotive company that has enhanced its new product development process by launching a forum and creating a virtual customers community. The research has been articulated into three main steps: 1) identification of the main areas of analysis: New Product Development Strategies and Collaborative Innovation Tools; 2) data collection through the observation of the Company’s forum and forum/blogs launched by other firms; questionnaires and face-to-face meetings with a manager in charge of new product development; 3) application of a web text mining model (Yin, et al., 2007) to extract relevant data from the information exchanged on the company’s forum. The preliminary results indicate that the ideas exchanged by customers on the company’s forum could be used in the phase of “New Ideas Generation” and “Product Concept Design”. The next step of this research is to implement the web text mining tool within the Company’s platform for relational marketing, in order to explore the links among the emerging ideas and recognize lead users

Relationship between plasma aldosterone levels and arterial stiffness parameters in hypertensive patients with subclinical vascular damage

Purpose: Aldosterone plays important role in cardiovascular damage. Aim was to evaluate arterial subclinical damage through arterial stiffness parameters in patients with Essential Hypertension (EH) and Primary Aldosteronism (PA).Methods: From 2018 to 2019 we consecutively enrolled 82 subjects (37 males and 45 women), distinguished in two groups: 60 EH [systolic blood pressure (SBP) 143.4 +/- 16.7 mmHg, diastolic blood pressure (DBP) 89.5 +/- 12.1 mmHg] and 22 PA (SBP 149 +/- 19.5 mmHg, DBP 92.7 +/- 12.4 mmHg) [5 with aldosterone-secreting adrenal adenoma(APA), 17 with idiopathic aldosteronism(IHA)]; 40 matched normotensive subjects (NS) were enrolled (SBP 109.7 +/- 6.2 mmHg, DBP 71.3 +/- 9.7 mmHg). We used non-invasive applanation tonometer to acquire pressure waveform.Results: PA patients showed higher mu-Albuminuria (UAE) (65.7 +/- 11.0mg/24 h) than EH and NS (21.5 +/- 7.0 mg/24 h and 21.5 +/- 7.0 mg/24 h, respectively); APA group showed increased levels of arterial stiffness index (11.7 +/- 4.8 m/s; p &lt; 0.02) compared to EH subjects (8.3 +/- 3 m/s) and NS subjects (7.2 +/- 1.7 m/s) as well as higher carotid intima-media thickness (c-IMT); APA patients showed significant reduction of subendocardial viability ratio (SEVR) and travel time of the reflected waves (TI) respect EH and NS. PA groups showed high percentage of augmented "worsening age" (60%), compared to EH (38%) and NS (37%). PAC was positively correlated with Arterial Stiffness Index. Performing multiple linear regression analysis (evaluating anthropometric and biochemical parameters), we found UAE as predictor of Augmentation Index, Arterial Stiffness Index and Travel Time of reflected waves in the enrolled population.Conclusion: PA patients showed higher cardiovascular subclinical damage respect to EH; UAE excretion had significant correlation with aldosterone, resulting best marker of subclinical vascular remodeling

ASSESSMENT OF VIABLE BUT HIBERNATING MYOCARDIUM BY ECHOCARDIOGRAPHY: COMPLEMENTARY ROLE OF COLOR KINESIS AND CYCLE-DEPENDENT VARIATION OF INTEGRATED BACKSCATTER.

Prague, Czech Republi