SystemC Model Generation for Realistic Simulation of Networked Embedded Systems

Verification and design-space exploration of today's embedded systems require the simulation of heterogeneous aspects of the system, i.e., software, hardware, communications. This work shows the use of SystemC to simulate a model-driven specification of the behavior of a networked embedded system together with a complete network scenario consisting of the radio channel, the IEEE 802.15.4 protocol for wireless personal area networks and concurrent traffic sharing the medium. The paper describes the main issues addressed to generate SystemC modules from Matlab/Stateflow descriptions and to integrate them in a complete network scenario. Simulation results on a healthcare wireless sensor network show the validity of the approach

Temperature and precipitation seasonal forecasts over the Mediterranean region: added value compared to simple forecasting methods

This study considers a set of state-of-the-art seasonal forecasting systems (ECMWF, MF, UKMO, CMCC, DWD and the corresponding multi-model ensemble) and quantifies their added value (if any) in predicting seasonal and monthly temperature and precipitation anomalies over the Mediterranean region compared to a simple forecasting method based on the ERA5 climatology (CTRL) or the persistence of the ERA5 anomaly (PERS). This analysis considers two starting dates, May 1st and November 1st and the forecasts at lead times up to 6 months for each year in the period 1993–2014. Both deterministic and probabilistic metrics are employed to derive comprehensive information on the forecast quality in terms of association, reliability/resolution, discrimination, accuracy and sharpness. We find that temperature anomalies are better reproduced than precipitation anomalies with varying spatial patterns across different forecast systems. The Multi-Model Ensemble (MME) shows the best agreement in terms of anomaly correlation with ERA5 precipitation, while PERS provides the best results in terms of anomaly correlation with ERA5 temperature. Individual forecast systems and MME outperform CTRL in terms of accuracy of tercile-based forecasts up to lead time 5 months and in terms of discrimination up to lead time 2 months. All seasonal forecast systems also outperform elementary forecasts based on persistence in terms of accuracy and sharpness

Usage personnel de pratiques relevant des médecines douces ou alternatives parmi les médecins suisses

L'importance de l'utilisation pour des besoins personnels de pratiques relevant des médecines douces ou alternatives parmi les médecins est très mal connue. Elle pourrait avoir plusieurs implications notamment par rapport à l'effort actuel de promotion de pratiques médicales fondées sur des preuves d'efficacité (Evidence-based medicine, EBM). [Auteurs]]]> fre oai:serval.unil.ch:BIB_F32E44E67757 2022-05-07T01:30:01Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_F32E44E67757 PAX5 activates the transcription of the human telomerase reverse transcriptase gene in B cells. info:doi:10.1002/path.2620 info:eu-repo/semantics/altIdentifier/doi/10.1002/path.2620 info:eu-repo/semantics/altIdentifier/pmid/19806612 Bougel, Stephanie Renaud, Stephanie Braunschweig, Richard Loukinov, Dmitri Morse Herbert C. III, Bosman Fred, T. Lobanenkov, Victor Benhattar, Jean info:eu-repo/semantics/article article 2010 Journal of Pathology, vol. 220, no. 1, pp. 87-96 info:eu-repo/semantics/altIdentifier/pissn/1096-9896[electronic] <![CDATA[Telomerase is an RNA-dependent DNA polymerase that synthesizes telomeric DNA. Its activity is not detectable in most somatic cells but it is reactivated during tumorigenesis. In most cancers, the combination of hTERT hypermethylation and hypomethylation of a short promoter region is permissive for low-level hTERT transcription. Activated and malignant lymphocytes express high telomerase activity, through a mechanism that seems methylation-independent. The aim of this study was to determine which mechanism is involved in the enhanced expression of hTERT in lymphoid cells. Our data confirm that in B cells, some T cell lymphomas and non-neoplastic lymph nodes, the hTERT promoter is unmethylated. Binding sites for the B cell-specific transcription factor PAX5 were identified downstream of the ATG translational start site through EMSA and ChIP experiments. ChIP assays indicated that the transcriptional activation of hTERT by PAX5 does not involve repression of CTCF binding. In a B cell lymphoma cell line, siRNA-induced knockdown of PAX5 expression repressed hTERT transcription. Moreover, ectopic expression of PAX5 in a telomerase-negative normal fibroblast cell line was found to be sufficient to activate hTERT expression. These data show that activation of hTERT in telomerase-positive B cells is due to a methylation-independent mechanism in which PAX5 plays an important role

Programmability and Performance of Parallel ECS-based Simulation of Multi-Agent Exploration Models

While the traditional objective of parallel/distributed simulation techniques has been mainly in improving performance and making very large models tractable, more recent research trends targeted complementary aspects, such as the “ease of programming”. Along this line, a recent proposal called Event and Cross State (ECS) synchronization, stands as a solution allowing to break the traditional programming rules proper of Parallel Discrete Event Simulation (PDES) systems, where the application code processing a specific event is only allowed to access the state (namely the memory image) of the target simulation object. In fact with ECS, the programmer is allowed to write ANSI-C event-handlers capable of accessing (in either read or write mode) the state of whichever simulation object included in the simulation model. Correct concurrent execution of events, e.g., on top of multi-core machines, is guaranteed by ECS with no intervention by the programmer, who is in practice exposed to a sequential-style programming model where events are processed one at a time, and have the ability to access the current memory image of the whole simulation model, namely the collection of the states of any involved object. This can strongly simplify the development of specific models, e.g., by avoiding the need for passing state information across concurrent objects in the form of events. In this article we investigate on both programmability and performance aspects related to developing/supporting a multi-agent exploration model on top of the ROOT-Sim PDES platform, which supports ECS