Distal radius fractures: treatment using the Epibloc system.

Summary The Epibloc™ system of percutaneous endomedullary internal fixation is best indicated for AO type A2-3 extra-articular fractures of the distal radius and AO type C1 slightly comminuted articular fractures. This system includes pins that can be inserted into the medullary canal and advanced without breaking through the second cortex. This fixation is stabilised by an external plate and rendered dynamic by the pins' elasticity which compresses the fractured surfaces. Moreover, this system results in transversal ligamentotaxis which helps prevent secondary reduction losses. The result of a preliminary series of 326 cases is evaluated

Dried blood spot UHPLC-MS/MS analysis of oseltamivir and oseltamivircarboxylate—a validated assay for the clinic

The neuraminidase inhibitor oseltamivir (Tamiflu®) is currently the first-line therapy for patients with influenza virus infection. Common analysis of the prodrug and its active metabolite oseltamivircarboxylate is determined via extraction from plasma. Compared with these assays, dried blood spot (DBS) analysis provides several advantages, including a minimum sample volume required for the measurement of drugs in whole blood. Samples can easily be obtained via a simple, non-invasive finger or heel prick. Mainly, these characteristics make DBS an ideal tool for pediatrics and to measure multiple time points such as those needed in therapeutic drug monitoring or pharmacokinetic studies. Additionally, DBS sample preparation, stability, and storage are usually most convenient. In the present work, we developed and fully validated a DBS assay for the simultaneous determination of oseltamivir and oseltamivircarboxylate concentrations in human whole blood. We demonstrate the simplicity of DBS sample preparation, and a fast, accurate and reproducible analysis using ultra high-performance liquid chromatography coupled to a triple quadrupole mass spectrometer. A thorough validation on the basis of the most recent FDA guidelines for bioanalytical method validation showed that the method is selective, precise, and accurate (≤15% RSD), and sensitive over the relevant clinical range of 5–1,500 ng/mL for oseltamivir and 20–1,500 ng/mL for the oseltamivircarboxylate metabolite. As a proof of concept, oseltamivir and oseltamivircarboxylate levels were determined in DBS obtained from healthy volunteers who received a single oral dose of Tamiflu®

A 'Power sharing model' (PSM) for buildings of the public administration

The new concept of renewable energy communities introduced by the Revised European Directive on the promotion of renewable sources (2018/2001) has opened new possibilities for microgrids. In fact, it permits to enhance the value of the energy produced by renewable sources sharing it inside an 'energy community' and to increase the social welfare. In the present paper, the authors investigated about the actual legislation framework on energy communities at European and Italian level, highlighting regulatory problems and barriers that are delaying their constitutions. The authors propose a 'power sharing model' (PSM) useful for energy communities and based on the sharing of renewables and other energy services. PSM is suitable both at building level and for larger communities. PSM has been analyzed through a case study that regards the preliminary study of a smart microgrid that should be realized in Campobasso, Italy, to connect buildings of the public administration. This scenario was investigated through a simulation conducted in Simulink environment were the control strategy was implemented, and the results were compared to a traditional configuration for renewable sources integration

Power sharing model for energy communities of buildings

The new concept of renewable energy communities introduced by the Revised European Directive on the promotion of renewable sources (2018/2001) has opened new possibilities for microgrids. In fact, it permits to enhance the value of the energy produced by renewable sources sharing it inside an 'energy community' and to increase the social welfare. In this article, the authors investigated about the actual legislation framework on energy communities at the European and Italian level, highlighting regulatory problems and barriers that are delaying their constitutions. The authors propose a 'power sharing model' (PSM), which is useful for energy communities based on the sharing of renewables and other energy services. The PSM is suitable for both the building level and larger communities. PSM has been analyzed through a case study that regards the preliminary study of a smart microgrid that should be realized in Campobasso, Italy, to connect buildings of the public administration. This scenario was investigated through a simulation conducted in Simulink environment where the control strategy was implemented, and the results were compared to a traditional configuration for renewable sources integration. The results highlight the adequacy of PSM for the energy community for the building's microgrids application