A Discussion on Dirac Field Theory, No-Go Theorems and Renormalizability

We study Dirac field equations coupled to electrodynamics with metric and torsion fields: we discuss how special spinorial solutions are incompatible with torsion; eventually these results will be used to sketch a discussion on the problem of renormalizability of point-like particles.Comment: 10 page

An empirical mass-loss law for Population II giants from the Spitzer-IRAC survey of Galactic globular clusters

The main aim of the present work is to derive an empirical mass-loss (ML) law for Population II stars in first and second ascent red giant branches. We used the Spitzer InfraRed Array Camera (IRAC) photometry obtained in the 3.6-8 micron range of a carefully chosen sample of 15 Galactic globular clusters spanning the entire metallicity range and sampling the vast zoology of horizontal branch (HB) morphologies. We complemented the IRAC photometry with near-infrared data to build suitable color-magnitude and color-color diagrams and identify mass-losing giant stars. We find that while the majority of stars show colors typical of cool giants, some stars show an excess of mid-infrared light that is larger than expected from their photospheric emission and that is plausibly due to dust formation in mass flowing from them. For these stars, we estimate dust and total (gas + dust) ML rates and timescales. We finally calibrate an empirical ML law for Population II red and asymptotic giant branch stars with varying metallicity. We find that at a given red giant branch luminosity only a fraction of the stars are losing mass. From this, we conclude that ML is episodic and is active only a fraction of the time, which we define as the duty cycle. The fraction of mass-losing stars increases by increasing the stellar luminosity and metallicity. The ML rate, as estimated from reasonable assumptions for the gas-to-dust ratio and expansion velocity, depends on metallicity and slowly increases with decreasing metallicity. In contrast, the duty cycle increases with increasing metallicity, with the net result that total ML increases moderately with increasing metallicity, about 0.1 Msun every dex in [Fe/H]. For Population II asymptotic giant branch stars, we estimate a total ML of <0.1 Msun, nearly constant with varying metallicity.Comment: 17 pages, 9 figures, in press on A&

Continuous haematic pH monitoring in extracorporeal circulation using a disposable florescence sensing element.

During extracorporeal circulation (ECC), blood is periodically sampled and analyzed to maintain the blood-gas status of the patient within acceptable limits. This protocol has well-known drawbacks that may be overcome by continuous monitoring. We present the characterization of a new pH sensor for continuous monitoring in ECC. This monitoring device includes a disposable fluorescence-sensing element directly in contact with the blood, whose fluorescence intensity is strictly related to the pH of the blood. In vitro experiments show no significant difference between the blood gas analyzer values and the sensor readings; after proper calibration, it gives a correlation of R>0.9887, and measuring errors were lower than the 3% of the pH range of interest (RoI) with respect to a commercial blood gas analyzer. This performance has been confirmed also by simulating a moderate ipothermia condition, i.e., blood temperature 32°C, frequently used in cardiac surgery. In ex vivo experiments, performed with animal models, the sensor is continuously operated in an extracorporeal undiluted blood stream for a maximum of 11 h. It gives a correlation of R>0.9431, and a measuring error lower than the 3% of the pH RoI with respect to laboratory techniques

Strontium and iron-doped barium cobaltite prepared by solution combustion synthesis: exploring a mixed-fuel approach for tailored intermediate temperature solid oxide fuel cell cathode materials

Ba0.5Sr0.5Co0.8Fe0.2O3–δ (BSCF) powders were prepared by solution combustion synthesis using single and double fuels. The effect of the fuel mixture on the main properties of this well-known solid oxide fuel cell cathode material with high oxygen ion and electronic conduction was investigated in detail. Results showed that the fuel mixture significantly affected the area-specific resistance of the BSCF cathode materials, by controlling the oxygen deficiency and stabilizing the Co2+ oxidation state. It was demonstrated that high fuel-to-metal cations molar ratios and high reducing power of the combustion fuel mixture are mainly responsible for the decreasing of the area-specific resistance of BSCF cathode materials. Moreover, a new metastable monoclinic phase with Ba0.5Sr0.5CO3 composition was discovered in the as-burned BSCF powders, enlarging the existing information on the BSCF phase formation mechanis

QCD

We discuss QCD studies that will be possible at LEP2. We examine both experimental and theoretical aspects of jets, fragmentation functions, multiplicities and particle spectra.Comment: 44 pages, Latex, epsfig, 18 figures, to appear on the Report of the Workshop on Physics at LEP2, CERN 96-01, vol. 1, 199

Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function

Background. Glioblastomas are the most aggressive type of brain tumor. A successful treatment should aim at halting tumor growth and protecting neuronal cells to prevent functional deficits and cognitive deterioration. Here, we exploited a Rho GTPase-activating bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1), to interfere with glioma cell growth in vitro and vivo. We also investigated whether this toxin spares neuron structure and function in peritumoral areas. Methods. We performed a microarray transcriptomic and in-depth proteomic analysis to characterize the molecular changes triggered by CNF1 in glioma cells. We also examined tumor cell senescence and growth in vehicle-and CNF1-treated glioma-bearing mice. Electrophysiological and morphological techniques were used to investigate neuronal alterations in peritumoral cortical areas. Results. Administration of CNF1 triggered molecular and morphological hallmarks of senescence in mouse and human glioma cells in vitro. CNF1 treatment in vivo induced glioma cell senescence and potently reduced tumor volumes. In peritumoral areas of glioma-bearing mice, neurons showed a shrunken dendritic arbor and severe functional alterations such as increased spontaneous activity and reduced visual responsiveness. CNF1 treatment enhanced dendritic length and improved several physiological properties of pyramidal neurons, demonstrating functional preservation of the cortical network. Conclusions. Our findings demonstrate that CNF1 reduces glioma volume while at the same time maintaining the physiological and structural properties of peritumoral neurons. These data indicate a promising strategy for the development of more effective antiglioma therapies