9 research outputs found
Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis
- Author
- A Falus
- AC Matzdorff
- AH Mil van der Helm-van
- AM El-Barbary
- AT Nurden
- AY Gasparyan
- AY Gasparyan
- BT Wipke
- D Projahn
- DG Scott
- DL Scott
- E Boilard
- E Boilard
- E.W. Nivine Levarht
- EA Knijff-Dutmer
- F Wang
- FA Gaalen van
- FC Arnett
- FJ LĂłpez-Longo
- G Cambridge
- G Hjeltnes
- G Lippi
- G Tomasson
- GE Pamuk
- H Demirin
- H Kubagawa
- H Maradit-Kremers
- I Ertenli
- I Matsumoto
- J Beinsberger
- JT Giles
- JT Gustafsson
- JW Semple
- K Nishimura
- Kim L.L. Habets
- KL Habets
- Leendert A. Trouw
- M King
- M Schmitt-Sody
- M Schmitt-Sody
- M Vergeer
- MD Berlacher
- ME Holmqvist
- N Cloutier
- N Tamura
- NJ Goodson
- O FitzGerald
- P Duffau
- P Pignatelli
- P Pignatelli
- PC Fink
- Petra A.M. Habets
- Philip de Groot
- PJ Mott
- R Gerli
- R Miguélez
- René E.M. Toes
- RG Espinola
- S Prahalad
- S Yazici
- S Yazici
- Suzanne J.A. Korporaal
- T Cheng
- Tom W.J. Huizinga
- V Henn
- WS Chung
- Y Huo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
SEC Enforcement: Does Disgorgement Have a Date with Destiny?
- Author
- 244 F Burger
- 367 F Pardue
- 814 F Bilzerian
- 814 F Bilzerian
- Berlacher
- Berlacher
- Berlacher
- Blavin
- C Critique
- Calvo
- Cf
- Cf
- Cir
- Cir
- D
- D C Cir
- D C Cir
- D C The
- E D Mich
- E D Mich
- E D Pa
- E D Pa
- E G See
- Ellsworth
- Ellsworth
- F
- F
- F
- F
- F Supp
- F Supp
- H R Rep
- H R Rep
- H R Rep
- Hughes Capital
- I I See Supra Parts
- Id
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- Id
- Id
- Id
- James Tyler Kirk
- Janigan V Taylor
- John D Ellsworth
- Jt Wallenbrock
- Kenton Capital
- Litton Indus
- M D Fla
- Mccaskey
- Mccaskey
- Mccaskey
- Miller
- NO 97civ Rosenfeld
- Pidcock V. Sunnyland
- R J Sec V
- Rosenfeld
- Rosenfeld
- Rosenfeld
- Rosenfeld
- S C
- S C
- S D Fla
- S D Fla
- S Rep
- S Rep
- S Rep NO
- Sec
- Sec
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- Sec V See
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- Sec V See
- Sec V See
- Sec V. Bilzerian
- Sec V. Brethan
- Sec V. First
- Sec V. First
- Sec V. Hughes Capital
- Sec V. Hughes Capital
- Sec V. Hughes Capital
- Sec V. Pardue
- Sec V. Penn
- Sec V. World Gambling
- Sec V. Yun
- See Berlacher
- See Id
- Shah
- Shah
- Shah
- Steadman
- Thomas James
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Landry-Guillain-Barre syndrome in children
- Author
- A. L. Kisch
- E. Clarke
- E. Reske-Nielson
- F. J. Berlacher
- G. Guillain
- G. Guillain
- G. H. Waksman
- G. L. Heller
- G. M. Taori
- G. S. Graveson
- H. G. Miller
- H. G. Miller
- I. B. Bourne
- I. H. Porter
- J. Marshall
- J. R. Bradford
- L. D. Osler
- M. J. Fiese
- M. Klein
- M. W. Kies
- N. L. Low
- O. Landry
- P. Aylett
- R. Debré
- R. G. Welch
- R. H. Jackson
- R. K. Nixon
- R. K. Seth
- R. M. Eiben
- R. Merrill
- S. C. Melnick
- W. Haymaker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Corticotrofina e cortiomdes em neurologia: avaliação critica dos resultados em 518 pacientes hospitalizados
- Author
- AINGER L. E.
- ALAJOUANINE Th.
- ALBERNAZ J. G.
- ALEXANDER L.
- ALEXANDER L.
- ALEXANDER L.
- ALLEN J. E.
- ARONSON N.
- ARROBA C. V.
- ASHBY M.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- ASSIS J. L.
- AUSTIN J. H.
- BAMMER H.
- BARNICK D. D.
- BASTRUP-MADSEN P.
- BAUMANN J.
- BERG J. M.
- BERLACHER F. J.
- BLOMBERG. L. H.
- BLOOD A.
- BOGAERT L. van
- BOWER B. D.
- BRANDRIN M. W.
- BRIGGS G. W.
- BROOKS W. D. W.
- CANELAS H. M.
- CANELAS H. M.
- CANELAS H. M.
- CANELAS H. M.
- CANELAS H. M.
- CANELAS H. M.
- CANELAS. H. M.
- CASS L. J.
- CLARKE E.
- CROZIER R. E.
- CUNNINGHAM V. R.
- DANILSEN J.
- DE JONG R. N.
- DESTAIGNE F.
- DIESSNER G. R.
- DOBBS J. M.
- DOERNER A. A.
- DRENICK E. J.
- EATON L. M.
- FELDMAN S.
- FELDMAN S.
- FERRARO A.
- FERRARO A.
- FERRARO A.
- FERRARO A.
- FERRARO A.
- FERRARO A.
- FINLAND M.
- FISCH A. M.
- FOG T.
- FOSTER J. B.
- FOT T.
- FREIDBERG L. D.
- FREUND J.
- FREUND J.
- FROST J. W.
- FROST J. W.
- FĂŤESE M. J.
- GAMMON G. A.
- GLASER G. H.
- GLASER G. H.
- GLASS G. B. J.
- GLASS G. B. J.
- GLASS G. B. J.
- GORDIN R.
- GRAVESON G. S.
- GROB D.
- GROB D.
- HALVORSEN S.
- HARTER J. G.
- HEITMANN R.
- HERBERT P. H.
- HOCKADAY J. M.
- HOECK von E.
- HOEFER P. F. A.
- HOWARD Jr. F. M.
- HOWARD Jr. F. M.
- HYLAND H.
- J. Lamartine de Assis
- JACKSON R. H.
- JAKLITSCH H.
- Jayme Tetner
- JERVIS G. A.
- JOHNSON J. R.
- JOHNSON J. R.
- JULIAO O. F.
- KABAT E. A.
- KABAT E. A.
- KANE C. A.
- KASS E. H.
- KASS E. H.
- KENDIG Jr. E. L.
- KIBLER R. F.
- KRISTENSEN H. P. O.
- LILJESTRAND A.
- LIVINGSTONE J. L.
- LOW N. L.
- LOW N. L.
- LUZES P. M.
- MARQUEZY R. A.
- MARTIN J. J.
- MASSEL B. F.
- McALPINE D.
- MERRITT H. H.
- MILLER H. G.
- MILLER H. G.
- MILLER H. G.
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- MILLICHARP J. G.
- MILLIKAN C. H.
- MORGAN I. M.
- MOUNT F. W.
- MOYER A. W.
- MULDER D. W.
- MĂśLLER W.
- NEWEY J. A.
- O'DOHERTY D. S.
- OSSERMAN K. E.
- OSSERMAN K. E.
- OTTO D.
- OVERMAN J. R.
- PAULLEY J. W.
- PEARSON C. M.
- PETTE H.
- PLOUGH I. C.
- PLUM F.
- REYS G. von
- REYS G. von
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- RITTER J. A.
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- WASZ-HOCKERT O.
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- ZIEGLER D. K.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Platelet-T cell aggregates in lung cancer patients: Implications for thrombosis
- Author
- A Metelli
- A Salas-Perdomo
- AA Khorana
- AA Khorana
- AD Michelson
- Adam J. Meisler
- AT Franco
- B Felding-Habermann
- B Kadlec
- BB Navi
- BB Navi
- C Ay
- C Zamora
- Cara M. Bird
- CE Chee
- CKS Meikle
- Claire K. Meikle
- Clare A. Kelly
- E Borges
- E Grilz
- E Romualdi
- E Salla
- Erin L. Crawford
- F Horsted
- F Scotté
- GH Lyman
- GP Davi
- H Kitagawa
- H Laubli
- H Zhang
- HT Sorensen
- J Jia
- James C. Willey
- Joseph A. Jeffries
- JW Blom
- L Asmis
- L Borsig
- Leah M. Wuescher
- M Chen
- M Davila
- M Messager
- M Tuzovic
- MD Berlacher
- MK Jensen
- N Mackman
- N van Es
- N van Es
- Nabila Azeem
- NS Key
- P Ferroni
- P Jurasz
- P Prandoni
- P Sanchez-Salcedo
- Pablo Garcia de Frutos
- Priyanka Garg
- R Simanek
- RA Moore
- Randall G. Worth
- RK Miglani
- S Emir
- S Rachidi
- Tess Z. Gao
- V Tagalakis
- W Chen
- X Zhou
- XR Xu
- Y Hisada
- Y Wang
- YW van den Berg
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Evolocumab and clinical outcomes in patients with cardiovascular disease
- Author
- Abelson M.
- Aboufakher R.
- Abrahamsen T. E.
- Accini Mendoza J. L.
- Acheatel R.
- Ackermann D.
- Adamkova V.
- Adams M.
- Adlam D.
- Aggarwal R.
- Aggarwal S.
- Ahsan A.
- Ainsworth P.
- Airody Govinda R.
- Akai A.
- Ako J.
- Al-Bahrani A.
- Al-Joundi T.
- Aldegather J.
- Aldrete Velasco J. A.
- Alfieri A.
- Alt I.
- Alzohaili O.
- Amerena J.
- Amin J.
- Amoedo R.
- Amuchastegui M.
- Anderson T.
- Andreka P.
- Andreotti F.
- Angoulvant D.
- Ansell B.
- Antalik L.
- Antkowiak-Piatyszek K.
- Appel K.
- Arakawa T.
- Arana Londoño C.
- Ardissino D.
- Ardito W. R.
- Arkhipov M.
- Arsenescu-Georgescu C.
- Asamoah N.
- Ascaso Gimilio J. F.
- Atar S.
- Atassi K.
- Athyros V.
- Auerbach E.
- Awtry E.
- Baass A.
- Badariene J.
- Badat A.
- Badila E.
- Bae J.
- Baigent C.
- Bain S.
- Baird I.
- Baker J.
- Balbay Y.
- Baldari D.
- Ballantyne C.
- Bammert A.
- Banach M.
- Bandh S.
- Banerjee S.
- Banik M.
- Banikova A.
- Barbarash O.
- Barcinas R.
- Barnum O.
- Barroso de Souza W. K.
- Bart B.
- Barton J.
- Bata I.
- Batalla E.
- Bayat J.
- Bazzoni Ruiz A. E.
- Bednarkiewicz Z.
- Beer H. J.
- Begg A.
- Beltrame J.
- Bendermacher P.
- Benton R.
- Berger C.
- Bergeron J.
- Bergler-Klein J.
- Berglund S.
- Berlacher P.
- Bernstein M.
- Bertolet B.
- Bertolim Precoma D.
- Bhagwat R.
- Bhargava R.
- Bhushan R.
- Biasucci L. M.
- Bilianou H.
- Blagden M.
- Blaha V.
- Blasko P.
- Blicharski T.
- Blignaut S.
- Blokhin A.
- Blumberg E.
- Bodanese L. C.
- Bokern M.
- Bolshakova O.
- Bonaca M. P.
- Bonnet B.
- Bosiljanoff P.
- Boswijk D.
- Botero Lopez R.
- Bourhaial H.
- Bousboulas S.
- Brabec T.
- Brezina B.
- Bronnum-Schou J.
- Brotanek J.
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- Brown C.
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- Cardona Muñoz E. G.
- Carhart R.
- Cariou B.
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- Case C.
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- Caulfield M.
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- Ceska R.
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- Charlier F.
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- Charvat J.
- Chauhan A.
- Cheek H. B.
- Chehayeb R.
- Chen J.
- Chen X.
- Chen Yu
- Chenu P.
- Cheung D.
- Cho Y.
- Choi D.
- Chopra V. K.
- Chorin E.
- Christensen T.
- Christofides E.
- Cifkova R.
- Civeira Murillo F.
- Cizinsky S.
- Clardy D.
- Claxton E.
- Clements B.
- Cobos J. L.
- Coching R. M.
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- Coisne D.
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- Colombo H.
- Coman I.
- Conejeros Kindel C.
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- Cordero Fort A.
- Cornel J. H.
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- Kanevsky E.
- Kania G.
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- Kashyap M.
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- Kawamitsu K.
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- Kayikcioglu L.
- Kazdera P.
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- Keeling P.
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- Yao Zhuhua
- Yasumura Y.
- Yataco A.
- Yeh H.
- Yena L.
- Yeoman G.
- Yigit Z.
- Yilmaz M. B.
- Yokoya K.
- Yoshimichi G.
- Yotov Y.
- Youngman D.
- Younis L.
- Yuge M.
- Zabowka M.
- Zahn L.
- Zamorano Gomez J. L.
- Zarich S.
- Zateyshchikov D.
- Zdrenghea D.
- Zechowicz T.
- Zeig S.
- Zemanek J.
- Zeng X.
- Zhang L.
- Zhang X.
- Zhao S.
- Zheng Y.
- Zheng Z.
- Zhou C.
- Zhu Y.
- Zhurba S.
- Zidkova E.
- Zieba B.
- Ziegler O.
- Zilahi Z.
- Zrazhevskiy K.
- Ă–stergren J.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
peer reviewedBACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%). CONCLUSIONS In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets. © 2017 Massachusetts Medical Society
ACC 2015 Core Cardiovascular Training Statement (COCATS 4) (Revision of COCATS 3)
- Author
- Ajay J. Kirtane
- Allen J. Solomon
- Ami B. Bhatt
- Ana Barac
- Andrew Wang
- Benjamin M. Scirica
- Bruce H. Gray
- Bruno V. Manno
- Carole A. Warnes
- Chittur A. Sivaram
- Christopher J. White
- Christopher J. White
- Christopher M. Kramer
- Christopher M. Kramer
- Curt J. Daniels
- Debabrata Mukherjee
- Donna M. Polk
- Douglas E. Drachman
- Emile R. Mohler
- Eric H. Awtry
- Eric R. Bates
- Eric S. Williams
- Eric S. Williams
- Gary J. Balady
- Geoffrey A. Rose
- George D. Dangas
- Harlan M. Krumholz
- Heather L. Gornik
- Hugh Calkins
- J. Michael Gaziano
- Jagat Narula
- James A. Arrighi
- James E. Udelson
- Jeffrey L. Williams
- Jeffrey M. Schussler
- Jeffrey T. Kuvin
- Jesse E. Adams
- John A. McPherson
- John C. Giacomini
- John E. Brush
- John M. Dent
- John M. Miller
- John R. Lesser
- Jonathan L. Halperin
- Jonathan L. Halperin
- Jonathan R. Lindner
- Joseph A. Hill
- Joseph C. Wu
- Joseph D. Babb
- Joseph L. Schuller
- Julia H. Indik
- Karen K. Stout
- Kathryn Berlacher
- Kyle W. Klarich
- L. Kristen Newby
- L. Samuel Wann
- Linda D. Gillam
- Lisa A. Mendes
- Maleah Grover-McKay
- Mariell Jessup
- Mario J. Garcia
- Mario J. Garcia
- Mark A. Creager
- Mark B. Taubman
- Mark H. Drazner
- Martha Gulati
- Marvin A. Konstam
- Matthew J. Budoff
- Matthew W. Martinez
- Michael A. Mathier
- Michael H. Crawford
- Michael S. Lauer
- Michele D. Voeltz
- Nancy K. Sweitzer
- Nancy R. Cho
- Naomi M. Hamburg
- Neil J. Stone
- Patrick T. O’Gara
- Prashant Vaishnava
- Quinn R. Pack
- R. Parker Ward
- Raymond Y. Kwong
- Reza Ardehali
- Robert A. Harrington
- Ron Blankstein
- Rose S. Cohen
- Sanjay Kaul
- Shaista Malik
- Sidney C. Smith
- Soma Sen
- Spencer B. King
- Stanley Wang
- Subha V. Raman
- Sunil V. Mankad
- Szilard Voros
- Thomas Jared Bunch
- Thomas Ryan
- Thomas Ryan
- Thoralf M. Sundt
- Todd D. Miller
- Usha B. Tedrow
- Valentin Fuster
- Valentin Fuster
- Vasken Dilsizian
- Vasken Dilsizian
- Vera Bittner
- Vincent J. Bufalino
- W. Gregory Hundley
- William F. Iobst
- William F. Iobst
- Y.S. Chandrashekhar
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
ACC 2015 Core Cardiovascular Training Statement (COCATS 4) (Revision of COCATS 3) A Report of the ACC Competency Management Committee
- Author
- Adams Jesse E.
- Ardehali Reza
- Arrighi James A.
- Awtry Eric H.
- Babb Joseph D.
- Balady Gary J.
- Barac Ana
- Bates Eric R.
- Berlacher Kathryn
- Bhatt Ami B.
- Bittner Vera
- Blankstein Ron
- Brush , John E.
- Budoff Matthew J.
- Bufalino Vincent J.
- Bunch Thomas Jared
- Calkins Hugh
- Chandrashekhar Y.S.
- Cho Nancy R.
- Cohen Rose S.
- Crawford Michael H.
- Creager Mark A.
- Dangas George D.
- Daniels Curt J.
- Dent John M.
- Dilsizian Vasken
- Dilsizian Vasken
- Drachman Douglas E.
- Drazner Mark H.
- Fuster Valentin
- Fuster Valentin
- Garcia Mario J.
- Garcia Mario J.
- Gaziano J. Michael
- Giacomini John C.
- Gillam Linda D.
- Gornik Heather L.
- Gray Bruce H.
- Grover-McKay Maleah
- Gulati Martha
- Halperin Jonathan L.
- Halperin Jonathan L.
- Hamburg Naomi M.
- Harrington Robert A.
- Hill Joseph A.
- Hundley W. Gregory
- Indik Julia H.
- Iobst William F.
- Iobst William F.
- Jessup Mariell
- Kaul Sanjay
- King Spencer B.
- Kirtane Ajay J.
- Klarich Kyle W.
- Konstam Marvin A.
- Kramer Christopher M.
- Kramer Christopher M.
- Krumholz Harlan M.
- Kuvin Jeffrey T.
- Kwong Raymond Y.
- Lauer Michael S.
- Lesser John R.
- Lindner Jonathan R.
- Malik Shaista
- Mankad Sunil V.
- Manno Bruno V.
- Martinez Matthew W.
- Mathier Michael A.
- McPherson John A.
- Mendes Lisa A.
- Miller John M.
- Miller Todd D.
- Mohler Emile R.
- Mukherjee Debabrata
- Narula Jagat
- Newby L. Kristen
- O’Gara Patrick T.
- Pack Quinn R.
- Polk Donna M.
- Raman Subha V.
- Rose Geoffrey A.
- Ryan Thomas
- Ryan Thomas
- Schuller Joseph L.
- Schussler Jeffrey M.
- Scirica Benjamin M.
- Sen Soma
- Sivaram Chittur A.
- Smith Sidney C.
- Solomon Allen J.
- Stone Neil J.
- Stout Karen K.
- Sundt Thoralf M.
- Sweitzer Nancy K.
- Taubman Mark B.
- Tedrow Usha B.
- Udelson James E.
- Vaishnava Prashant
- Voeltz Michele D.
- Voros Szilard
- Wang Andrew
- Wang Stanley
- Wann L. Samuel
- Ward R. Parker
- Warnes Carole A.
- White Christopher J.
- White Christopher J.
- Williams Eric S.
- Williams Eric S.
- Williams Jeffrey L.
- Wu Joseph C.
- Publication venue
- American College of Cardiology Foundation. Published by Elsevier Inc.
- Publication date
- Field of study
Evolocumab and clinical outcomes in patients with cardiovascular disease
- Author
- Abelson M
- Aboufakher R
- Abrahamsen Te
- Accini Mendoza Jl
- Acheatel R
- Ackermann D
- Adamkova V
- Adams M
- Adlam D
- Aggarwal R
- Aggarwal S
- Ahsan A
- Ainsworth P
- Airody Govinda R
- Akai A
- Ako J
- Al-Bahrani A
- Al-Joundi T
- Aldegather J
- Aldrete Velasco Ja
- Alfieri A
- Alt I
- Alzohaili O
- Amerena J
- Amin J
- Amoedo R
- Amuchastegui M
- Anderson T
- Andreka P
- Andreotti F
- Angoulvant D
- Ansell B
- Antalik L
- Antkowiak-Piatyszek K
- Appel K
- Arakawa T
- Arana Londoño C
- Ardissino D
- Ardito Wr
- Arkhipov M
- Arsenescu-Georgescu C
- Asamoah N
- Ascaso Gimilio Jf
- Atar S
- Atassi K
- Athyros V
- Auerbach E
- Awtry E
- Baass A
- Badariene J
- Badat A
- Badila E
- Bae J
- Baigent C
- Bain S
- Baird I
- Baker J
- Balbay Y
- Baldari D
- Ballantyne C
- Bammert A
- Banach M
- Bandh S
- Banerjee S
- Banik M
- Banikova A
- Barbarash O
- Barcinas R
- Barnum O
- Barroso de Souza Wk
- Bart B
- Barton J
- Bata I
- Batalla E
- Bayat J
- Bazzoni Ruiz Ae
- Bednarkiewicz Z
- Beer Hj
- Begg A
- Beltrame J
- Bendermacher P
- Benton R
- Berger C
- Bergeron J
- Bergler-Klein J
- Berglund S
- Berlacher P
- Bernstein M
- Bertolet B
- Bertolim Precoma D
- Bhagwat R
- Bhargava R
- Bhushan R
- Biasucci Lm
- Bilianou H
- Blagden M
- Blaha V
- Blasko P
- Blicharski T
- Blignaut S
- Blokhin A
- Blumberg E
- Bodanese Lc
- Bokern M
- Bolshakova O
- Bonaca Mp
- Bonnet B
- Bosiljanoff P
- Boswijk D
- Botero Lopez R
- Bourhaial H
- Bousboulas S
- Brabec T
- Brezina B
- Bronnum-Schou J
- Brotanek J
- Broughton R
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- Brown Wv
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- Budoff M
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- Burianova H
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- Bystryk L
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- Ulla Mr
- Urbach D
- Urgeova L
- Vaclavik J
- Vakaliuk I
- Valdes Chavarri M
- Vally T
- Valter I
- Van Beek E
- van de Borne P
- van de Wal R
- van der Walt E
- van der Zwaan C
- Van Gaal W
- Van Hessen M
- Van Zyl L
- Vanbelle E
- Vandekerckhove H
- Vasco Salgado A
- Vawda G
- Velchev V
- Venceviciene L
- Venegas Carrillo La
- Verheye S
- Vertes G
- Veze I
- Vida Gutierrez M
- Vidotti Mh
- Viigimaa M
- Vijay N
- Vikman S
- Vinanska D
- Vintila Mm
- Violante Ortiz Rm
- Vishnevsky A
- Visman A
- Vita J
- Voevoda M
- Vogel Dr
- Volkov V
- Vomacka Z
- von Hodenberg E
- Vora K
- Vorpahl M
- Wada A
- Wagner S
- Wan Ahmad Wa
- Wang D
- Wang Huei
- Wang J
- Wasserman Scott M.
- Waxman F
- Webel R
- Webster J
- Weinberg B
- Weinstein D
- Welker J
- Wermuth S
- Westendorp I
- Weyland K
- Whitney R
- Wierzbicka K
- Wilhoit G
- Wilson S
- Wise J
- Wiseman A
- Witt N
- Wittert G
- Wiviott Stephen D.
- Wnetrzak-Michalska R
- Wollaert B
- Wood Sk
- Wozakowska-Kaplon B
- Wozniak I
- Wu C
- Wyatt N
- Wöhrle J
- Xu P
- Xue L
- Yakhontova P
- Yamamoto K
- Yamashita K
- Yan J
- Yang E
- Yang P
- Yang X
- Yang Y
- Yang Z
- Yao Z
- Yasumura Y
- Yataco A
- Yeh H
- Yena L
- Yeoman G
- Yigit Z
- Yilmaz Mb
- Yokoya K
- Yoshimichi G
- Yotov Y
- Youngman D
- Younis L
- Yuge M
- Zabowka M
- Zahn L
- Zamorano Gomez Jl
- Zarich S
- Zateyshchikov D
- Zdrenghea D
- Zechowicz T
- Zeig S
- Zemanek J
- Zeng X
- Zhang L
- Zhang X
- Zhao S
- Zheng Y
- Zheng Z
- Zhou C
- Zhu Y
- Zhurba S
- Zidkova E
- Zieba B
- Ziegler O
- Zilahi Z
- Zrazhevskiy K
- Ă–stergren J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%). CONCLUSIONS In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets