An Improvement of the Asymptotic Iteration Method for Exactly Solvable Eigenvalue Problems

We derive a formula that simplifies the original asymptotic iteration method formulation to find the energy eigenvalues for the analytically solvable cases. We then show that there is a connection between the asymptotic iteration and the Nikiforov--Uvarov methods, which both solve the second order linear ordinary differential equations analytically.Comment: RevTex4, 8 page

Two-dimensional Schr\"odinger Hamiltonians with Effective Mass in SUSY Approach

The general solution of SUSY intertwining relations of first order for two-dimensional Schr\"odinger operators with position-dependent (effective) mass is built in terms of four arbitrary functions. The procedure of separation of variables for the constructed potentials is demonstrated in general form. The generalization for intertwining of second order is also considered. The general solution for a particular form of intertwining operator is found, its properties - symmetry, irreducibility, separation of variables - are investigated.Comment: 16 page

Approximate Solution of the effective mass Klein-Gordon Equation for the Hulthen Potential with any Angular Momentum

The radial part of the effective mass Klein-Gordon equation for the Hulthen potential is solved by making an approximation to the centrifugal potential. The Nikiforov-Uvarov method is used in the calculations. Energy spectra and the corresponding eigenfunctions are computed. Results are also given for the case of constant mass.Comment: 12 page

Ordering ambiguity revisited via position dependent mass pseudo-momentum operators

Ordering ambiguity associated with the von Roos position dependent mass (PDM) Hamiltonian is considered. An affine locally scaled first order differential introduced, in Eq.(9), as a PDM-pseudo-momentum operator. Upon intertwining our Hamiltonian, which is the sum of the square of this operator and the potential function, with the von Roos d-dimensional PDM-Hamiltonian, we observed that the so-called von Roos ambiguity parameters are strictly determined, but not necessarily unique. Our new ambiguity parameters' setting is subjected to Dutra's and Almeida's [11] reliability test and classified as good ordering.Comment: 10 pages, no figures, revised/expanded, mathematical presentations in section 2 (Especially, the typological Errors in Eqs.(9)-(12))are now corrected. To appear in the Int. J. Theor. Phy

Entry-level career paths in the life sciences: generic skills in Dutch job postings

The importance of generic skills for life scientists is commonly recognised by employers, graduates, and higher education institutes. As it remains unclear which generic skills are relevant for different life sciences career paths, this study aims to give an overview to inform and inspire universities and students, by analysing 179 Dutch entry-level job postings. We deductively coded nine career paths, namely: life sciences industry, PhD-student, quality compliance, research-related, sales & business, communication/education, information technology, consultancy, and policy. We coded generic skills using an adapted categorisation consisting of 46 generic skills within four categories, which were: self, others, information, and tasks. The descriptive statistics and cluster analysis results showed that although language, communication, and collaboration were the most requested skills, differences in requested generic skills between career paths and cluster composition were observed as well. We concluded that although some generic skills are important in general, other generic skills are relevant for specific life sciences career paths. To educate skilled life scientists, universities should consider the flexible integration of these generic skills in their life sciences programmes

Plasma Brain-Derived Neurotrophic Factor Levels Predict the Clinical Outcome of Depression Treatment in a Naturalistic Study

Remission is the primary goal of treatment for major depressive disorder (MDD). However, some patients do not respond to treatment. The main purpose of this study was to determine whether brain-derived neurotrophic factor (BDNF) levels are correlated with treatment outcomes. In a naturalistic study, we assessed whether plasma BDNF levels were correlated with clinical outcomes by measuring plasma BDNF in patients with depressive syndrome (MADRS score ≥18), and subsequently comparing levels between the subgroup of patients who underwent remission (MADRS score ≤8) and the subgroup who were refractory to treatment (non-responders). Patients with depressive syndrome who underwent remission had significantly higher plasma BDNF levels (p<0.001), regardless of age or sex. We also found a significant negative correlation between MADRS scores and plasma BDNF levels within this group (ρ = –0.287, p = 0.003). In contrast, non-responders had significantly lower plasma BDNF levels (p = 0.029). Interestingly, plasma BDNF levels in the non-responder group were significantly higher than those in the remission group in the initial stage of depressive syndrome (p = 0.002). Our results show that plasma BDNF levels are associated with clinical outcomes during the treatment of depression. We suggest that plasma BDNF could potentially serve as a prognostic biomarker for depression, predicting clinical outcome

Pericyte Migration: A Novel Mechanism of Pericyte Loss in Experimental Diabetic Retinopathy

OBJECTIVE— The mechanism underlying pericyte loss during incipient diabetic retinopathy remains controversial. Hyperglycemia induces angiopoietin-2 (Ang-2) transcription, which modulates capillary pericyte coverage. In this study, we assessed loss of pericyte subgroups and the contribution of Ang-2 to pericyte migration

A General Approach for the Exact Solution of the Schrodinger Equation

The Schr\"{o}dinger equation is solved exactly for some well known potentials. Solutions are obtained reducing the Schr\"{o}dinger equation into a second order differential equation by using an appropriate coordinate transformation. The Nikiforov-Uvarov method is used in the calculations to get energy eigenvalues and the corresponding wave functions.Comment: 20 page

A cross-sectional evidence-based review of pharmaceutical promotional marketing brochures and their underlying studies: Is what they tell us important and true?

BACKGROUND: A major marketing technique used by pharmaceutical companies is direct-to-physician marketing. This form of marketing frequently employs promotional marketing brochures, based on clinical research, which may influence how a physician prescribes medicines. This study's objective was to investigate whether or not the information in promotional brochures presented to physicians by pharmaceutical representatives is accurate, consistent, and valid with respect to the actual studies upon which the promotional brochures are based. METHODS: Physicians in five clinics were asked to consecutively collect pharmaceutical promotional brochures and to send them all to a centralized location. The brochures for any class of medication were collected on a continuous basis until 20 distinct promotional brochures were received by a central location. Once the brochure was received, the corresponding original study was obtained. Two blinded reviewers performed an evidence-based review of the article, comparing data that was printed on the brochure to what was found in the original study. RESULTS: Among the 20 studies, 75% of the studies were found to be valid, 80% were funded by the pharmaceutical company, 60% of the studies and the corresponding brochures presented patient-oriented outcomes, and 40% were compared to another treatment regimen. Of the 19 brochures that presented the data as graphs, 4 brochures presented a relative risk reduction while only 1 brochure presented an absolute risk reduction. 15% of the promotional marketing brochures presented data that was different from what was in the original published study. CONCLUSION: Given the present findings, physicians should be cautious about drawing conclusions regarding a medication based on the marketing brochures provided by pharmaceutical companies

The impact of customer-specific marketing expenses on customer retention and customer profitability

We study the effects of customer-specific marketing expenses on customer retention and customer profitability in a business-to-business setting. Using data from a company providing hygiene services, we look at the impact of a hitherto unstudied type of expense targeted at individual customer relationships: the offering of free equipment to customers. The data allow tracking the activities performed in more than 4,500 customer relationships over a period of 4 years. Retention rates are higher for customers targeted with free equipment, but this effect results from an interaction with customer size. First-order dynamic panel data analyses show that the impact of targeted marketing expenses on customer dollar profit is positive for large customers, but there is no effect for smaller customers. Thus, targeted marketing expenses seem to be a tool for relationship maintenance rather than customer development: they help in retaining large customers that generate more profit, but they do not seem to work in developing new customers into larger, more profitable ones