1,287 research outputs found
Estimating Be Star Disk Radii using H-alpha Emission Equivalent Widths
We present numerical models of the circumstellar disks of Be stars, and we
describe the resulting synthetic H-alpha emission lines and maps of the
wavelength-integrated emission flux projected onto the sky. We demonstrate that
there are monotonic relationships between the emission line equivalent width
and the ratio of the angular half-width at half maximum of the projected disk
major axis to the radius of the star. These relationships depend mainly upon
the temperatures of the disk and star, the inclination of the disk normal to
the line of sight, and the adopted outer boundary for the disk radius. We show
that the predicted H-alpha disk radii are consistent with those observed
directly through long baseline interferometry of nearby Be stars (especially
once allowance is made for disk truncation in binaries and for dilution of the
observed H-alpha equivalent width by continuum disk flux in the V-band).Comment: 12 pages, 2 figures, ApJL in pres
Weyl-Underhill-Emmrich quantization and the Stratonovich-Weyl quantizer
Weyl-Underhill-Emmrich (WUE) quantization and its generalization are
considered. It is shown that an axiomatic definition of the Stratonovich-Weyl
(SW) quantizer leads to severe difficulties. Quantization on the cylinder
within the WUE formalism is discussed.Comment: 15+1 pages, no figure
Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway.
BACKGROUND: Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation and selection by "in silico" experimentation. An obstacle to widespread adoption of this approach is the requirement to formulate a biological pathway as machine executable computer code. We have recently proposed a novel, biologically intuitive, narrative-style modelling language for biologists to formulate the pathway which is then automatically translated into an executable format and is, thus, usable for analysis via existing simulation techniques. RESULTS: Here we use a high-level narrative language in designing a computational model of the gp130/JAK/STAT signalling pathway and show that the model reproduces the dynamic behaviour of the pathway derived by biological observation. We then "experiment" on the model by simulation and sensitivity analysis to define those parameters which dominate the dynamic behaviour of the pathway. The model predicts that nuclear compartmentalisation and phosphorylation status of STAT are key determinants of the pathway and that alternative mechanisms of signal attenuation exert their influence on different timescales. CONCLUSION: The described narrative model of the gp130/JAK/STAT pathway represents an interesting case study showing how, by using this approach, researchers can model biological systems without explicitly dealing with formal notations and mathematical expressions (typically used for biochemical modelling), nevertheless being able to obtain simulation and analysis results. We present the model and the sensitivity analysis results we have obtained, that allow us to identify the parameters which are most sensitive to perturbations. The results, which are shown to be in agreement with existing mathematical models of the gp130/JAK/STAT pathway, serve us as a form of validation of the model and of the approach itself
Constraining Disk Parameters of Be Stars using Narrowband H-alpha Interferometry with the NPOI
Interferometric observations of two well-known Be stars, gamma Cas and phi
Per, were collected and analyzed to determine the spatial characteristics of
their circumstellar regions. The observations were obtained using the Navy
Prototype Optical Interferometer equipped with custom-made narrowband filters.
The filters isolate the H-alpha emission line from the nearby continuum
radiation, which results in an increased contrast between the interferometric
signature due to the H-alpha-emitting circumstellar region and the central
star. Because the narrowband filters do not significantly attenuate the
continuum radiation at wavelengths 50 nm or more away from the line, the
interferometric signal in the H-alpha channel is calibrated with respect to the
continuum channels. The observations used in this study represent the highest
spatial resolution measurements of the H-alpha-emitting regions of Be stars
obtained to date. These observations allow us to demonstrate for the first time
that the intensity distribution in the circumstellar region of a Be star cannot
be represented by uniform disk or ring-like structures, whereas a Gaussian
intensity distribution appears to be fully consistent with our observations.Comment: 23 pages, 14 figures, accepted for publication in A
Stellar Rotation in Young Clusters. II. Evolution of Stellar Rotation and Surface Helium Abundance
We derive the effective temperatures and gravities of 461 OB stars in 19
young clusters by fitting the H-gamma profile in their spectra. We use
synthetic model profiles for rotating stars to develop a method to estimate the
polar gravity for these stars, which we argue is a useful indicator of their
evolutionary status. We combine these results with projected rotational
velocity measurements obtained in a previous paper on these same open clusters.
We find that the more massive B-stars experience a spin down as predicted by
the theories for the evolution of rotating stars. Furthermore, we find that the
members of binary stars also experience a marked spin down with advanced
evolutionary state due to tidal interactions. We also derive non-LTE-corrected
helium abundances for most of the sample by fitting the He I 4026, 4387, 4471
lines. A large number of helium peculiar stars are found among cooler stars
with Teff < 23000 K. The analysis of the high mass stars (8.5 solar masses < M
< 16 solar masses) shows that the helium enrichment process progresses through
the main sequence (MS) phase and is greater among the faster rotators. This
discovery supports the theoretical claim that rotationally induced internal
mixing is the main cause of surface chemical anomalies that appear during the
MS phase. The lower mass stars appear to have slower rotation rates among the
low gravity objects, and they have a large proportion of helium peculiar stars.
We suggest that both properties are due to their youth. The low gravity stars
are probably pre-main sequence objects that will spin up as they contract.
These young objects very likely host a remnant magnetic field from their natal
cloud, and these strong fields sculpt out surface regions with unusual chemical
abundances.Comment: 50 pages 18 figures, accepted by Ap
Association Between State Policies Using Medicaid Exclusions to Sanction Noncompliance With Welfare Work Requirements and Medicaid Participation Among Low-Income Adults
Twenty states have pursued community engagement requirements (ie, work requirements) as a condition for Medicaid eligibility among adults considered able-bodied. Work requirements seek to improve health by incentivizing work, but may result in coverage losses.
The impact of work requirements on Medicaid coverage may extend beyond qualifying beneficiaries, by increasing confusion around benefit rules or deterring individuals from applying for coverage. However, the spillover effects of work requirements on individuals not directly subject to them are difficult to study because these programs have only recently been implemented. To examine this possibility, we studied Temporary Assistance for Needy Families (TANF), the cash welfare program enacted under welfare reform in 1996. The TANF program requires able-bodied beneficiaries to fulfill work requirements, and states can elect to terminate Medicaid benefits as a sanction for nonpregnant adult TANF participants who do not comply with them. In states adopting these sanctions, Medicaid eligibility for dual TANF-Medicaid enrollees was effectively conditional on meeting work requirements. This quasi-experimental cohort study examines whether TANF-Medicaid sanctions had spillover effects on Medicaid coverage among low-income adults who were not likely to participate in TANF and, therefore, were not directly subject to these sanctions
Ancient Migratory Events in the Middle East: New Clues from the Y-Chromosome Variation of Modern Iranians
Knowledge of high resolution Y-chromosome haplogroup diversification within Iran provides important geographic context regarding the spread and compartmentalization of male lineages in the Middle East and southwestern Asia. At present, the Iranian population is characterized by an extraordinary mix of different ethnic groups speaking a variety of Indo-Iranian, Semitic and Turkic languages. Despite these features, only few studies have investigated the multiethnic components of the Iranian gene pool. In this survey 938 Iranian male DNAs belonging to 15 ethnic groups from 14 Iranian provinces were analyzed for 84 Y-chromosome biallelic markers and 10 STRs. The results show an autochthonous but non-homogeneous ancient background mainly composed by J2a sub-clades with different external contributions. The phylogeography of the main haplogroups allowed identifying post-glacial and Neolithic expansions toward western Eurasia but also recent movements towards the Iranian region from western Eurasia (R1b-L23), Central Asia (Q-M25), Asia Minor (J2a-M92) and southern Mesopotamia (J1-Page08). In spite of the presence of important geographic barriers (Zagros and Alborz mountain ranges, and the Dasht-e Kavir and Dash-e Lut deserts) which may have limited gene flow, AMOVA analysis revealed that language, in addition to geography, has played an important role in shaping the nowadays Iranian gene pool. Overall, this study provides a portrait of the Y-chromosomal variation in Iran, useful for depicting a more comprehensive history of the peoples of this area as well as for reconstructing ancient migration routes. In addition, our results evidence the important role of the Iranian plateau as source and recipient of gene flow between culturally and genetically distinct population
Determining the Physical Properties of the B Stars I. Methodology and First Results
We describe a new approach to fitting the UV-to-optical spectra of B stars to
model atmospheres and present initial results. Using a sample of lightly
reddened stars, we demonstrate that the Kurucz model atmospheres can produce
excellent fits to either combined low dispersion IUE and optical photometry or
HST FOS spectrophotometry, as long as the following conditions are fulfilled:
1) an extended grid of Kurucz models is employed,
2) the IUE NEWSIPS data are placed on the FOS absolute flux system using the
Massa & Fitzpatrick (1999) transformation, and
3) all of the model parameters and the effects of interstellar extinction are
solved for simultaneously.
When these steps are taken, the temperatures, gravities, abundances and
microturbulence velocities of lightly reddened B0-A0 V stars are determined to
high precision. We also demonstrate that the same procedure can be used to fit
the energy distributions of stars which are reddened by any UV extinction curve
which can be expressed by the Fitzpatrick & Massa (1990) parameterization
scheme.
We present an initial set of results and verify our approach through
comparisons with angular diameter measurements and the parameters derived for
an eclipsing B star binary. We demonstrate that the metallicity derived from
the ATLAS 9 fits to main sequence B stars is essentially the Fe abundance. We
find that a near zero microturbulence velocity provides the best-fit to all but
the hottest or most luminous stars (where it may become a surrogate for
atmospheric expansion), and that the use of white dwarfs to calibrate UV
spectrophotometry is valid.Comment: 17 pages, including 2 pages of Tables and 6 pages of Figures.
Astrophysical Jounral, in pres
BMP action in skeletogenesis involves attenuation of retinoid signaling
The bone morphogenetic protein (BMP) and growth and differentiation factor (GDF) signaling pathways have well-established and essential roles within the developing skeleton in coordinating the formation of cartilaginous anlagen. However, the identification of bona fide targets that underlie the action of these signaling molecules in chondrogenesis has remained elusive. We have identified the gene for the retinoic acid (RA) synthesis enzyme Aldh1a2 as a principal target of BMP signaling; prochondrogenic BMPs or GDFs lead to attenuation of Aldh1a2 expression and, consequently, to reduced activation of the retinoid signaling pathway. Consistent with this, antagonism of retinoid signaling phenocopies BMP4 action, whereas RA inhibits the chondrogenic stimulatory activity of BMP4. BMP4 also down-regulates Aldh1a2 expression in organ culture and, consistent with this, Aldh1a2 is actively excluded from the developing cartilage anlagens. Collectively, these findings provide novel insights into BMP action and demonstrate that BMP signaling governs the fate of prechondrogenic mesenchyme, at least in part, through regulation of retinoid signaling
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