Self-force of a point charge in the space-time of a massive wormhole

We consider the self-potential and the self-force for an electrically charged particle at rest in the massive wormhole space-time. We develop general approach for the renormalization of electromagnetic field of such particle in the static space-times and apply it to the space-time of the wormhole with parameter of the mass, $m$. The self-force is found in manifest form; it is an attractive force. We discus the peculiarities due to massive parameter of the wormhole.Comment: 10 pages, 1 figure text correcte

СОВРЕМЕННЫЕ ИССЛЕДОВАНИЯ ПЕРСОНАЛА. СОЦИОЛОГИЧЕСКИЙ АНАЛИЗ УПРАВЛЕНИЯ ПЕРСОНАЛОМ И ЗАНЯТОСТЬЮ В ДИССЕРТАЦИОННЫХ ИССЛЕДОВАНИЯХ

The article is based on dissertation papers of PhD and Ph.D. defended in the last decade on the subject of human resource management and employment in general. The article discusses the features of professional development in modern Russia. In view of the development of information technology the need to use knowledge management technologies as a basis for professional development of the individual is highlighted. In this regard, particular attention is paid to the development of the ICT sector personnel, and it is noted the importance of the impact of the transformation of the national education system in the development of personnel in Russia, in particular the transition to a competence-based approach. The article also highlights key factors of motivation of different categories of employees, current models of material and immaterial motivation, special attention is paid to the destructive model of motivation. In the conditions of transitive economy it is important to highlight the features of a new type of employment and the corresponding ways of organizing work in a globalized, postindustrial society. In this regard, special attention is paid to the mechanisms for effective management of employment in the social market economy. Moreover, there is a need of an active employment policy in Russia, resulting in the need to fill labor shortages in the country. One of the most effective ways to solve this problem is the labor migration. Статья основана на диссертациях кандидатов и докторов наук, защищенных в последнее десятилетие по тематике управления персоналом и занятости в целом. В статье рассматриваются особенности профессионального развития персонала в современной России. Ввиду развития информационных технологий подчеркивается необходимость использования технологии управления знаниями в качестве основы профессионального развития личности. В данной связи особое внимание уделяется вопросу развития персонала сферы информационно-коммуникационных технологий (ИКТ), а также отмечается важность влияния трансформации отечественной системы образования на развитие персонала в России, в частности ее переход к компетентностному подходу. В статье также выделяются ключевые факторы трудовой мотивации различных категорий работников, современные модели материальной и нематериальной мотивации персонала, особое внимание уделяется модели деструктивной мотивации. В условиях транзитивной экономики немаловажно выделить особенности занятости нового типа и соответствующие ей способы организации трудовой деятельности в глобализирующемся, постиндустриальном обществе. В связи с этим отдельное внимание уделяется рассмотрению механизмов эффективного управления занятостью в социально-ориентированной рыночной экономике. Помимо этого, отмечается потребность проведения активной политики занятости в России, что обусловливает необходимость восполнения дефицита рабочей силы в стране. В качестве одного из наиболее эффективных способов решения данной проблемы выступает трудовая миграция. 

The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBP β

Colorectal cancer is one of the most common cancers in the world. It is well known that the chronic inflammation can promote the progression of colorectal cancer (CRC). Recently, a number of studies revealed a potential association between colorectal inflammation, cancer progression, and infection caused by enterotoxigenic Bacteroides fragilis (ETBF). Bacterial enterotoxin activates spermine oxidase (SMO), which produces spermidine and H2O2 as byproducts of polyamine catabolism, which, in turn, enhances inflammation and tissue injury. Using qPCR analysis, we estimated the expression of SMOX gene and ETBF colonization in CRC patients. We found no statistically significant associations between them. Then we selected genes involved in polyamine metabolism, metabolic reprogramming, and inflammation regulation and estimated their expression in CRC. We observed overexpression of SMOX, ODC1, SRM, SMS, MTAP, c-Myc, C/EBPβ (CREBP), and other genes. We found that two mediators of metabolic reprogramming, inflammation, and cell proliferation c-Myc and C/EBPβ may serve as regulators of polyamine metabolism genes (SMOX, AZIN1, MTAP, SRM, ODC1, AMD1, and AGMAT) as they are overexpressed in tumors, have binding site according to ENCODE ChIP-Seq data, and demonstrate strong coexpression with their targets. Thus, increased polyamine metabolism in CRC could be driven by c-Myc and C/EBPβ rather than ETBF infection

Aspergillus Myosin-V Supports Polarized Growth in the Absence of Microtubule-Based Transport

In the filamentous fungus Aspergillus nidulans, both microtubules and actin filaments are important for polarized growth at the hyphal tip. Less clear is how different microtubule-based and actin-based motors work together to support this growth. Here we examined the role of myosin-V (MYOV) in hyphal growth. MYOV-depleted cells form elongated hyphae, but the rate of hyphal elongation is significantly reduced. In addition, although wild type cells without microtubules still undergo polarized growth, microtubule disassembly abolishes polarized growth in MYOV-depleted cells. Thus, MYOV is essential for polarized growth in the absence of microtubules. Moreover, while a triple kinesin null mutant lacking kinesin-1 (KINA) and two kinesin-3s (UNCA and UNCB) undergoes hyphal elongation and forms a colony, depleting MYOV in this triple mutant results in lethality due to a severe defect in polarized growth. These results argue that MYOV, through its ability to transport secretory cargo, can support a significant amount of polarized hyphal tip growth in the absence of any microtubule-based transport. Finally, our genetic analyses also indicate that KINA (kinesin-1) rather than UNCA (kinesin-3) is the major kinesin motor that supports polarized growth in the absence of MYOV

The study of oncolytic viruses reproduction in organ cultures of human lymphoid tumors

Oncolytic viruses are promising agents for the treatment of various types of tumors, including malignant non-Hodgkin lymphomas. In order to identify the most effective candidates from a wide panel of non-pathogenic antitumor strains, a study was carried out of their ability to reproduce in short-term cultures of lymphoid tumor cells. Also, tumor cell cultures were characterized in relation to the presence of specific viral receptors CD54, CD55, CD155 on their surface