The compact, ∼1 kpc host galaxy of a quasar at a redshift of 7.1

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations of the [C ii] fine-structure line and the underlying far-infrared (FIR) dust continuum emission in J1120+0641, the most distant quasar currently known ($z=7.1$). We also present observations targeting the CO(2–1), CO(7–6), and [C i] 369 μm lines in the same source obtained at the Very Large Array and Plateau de Bure Interferometer. We find a [C ii] line flux of ${F}_{[{\rm{C}}{\rm{II}}]}=1.11\pm 0.10$ Jy $\mathrm{km}\,{{\rm{s}}}^{-1}$ and a continuum flux density of ${S}_{227\mathrm{GHz}}=0.53\pm 0.04$ mJy beam−1, consistent with previous unresolved measurements. No other source is detected in continuum or [C ii] emission in the field covered by ALMA (~ 25''). At the resolution of our ALMA observations (0farcs23, or 1.2 kpc, a factor of ~70 smaller beam area compared to previous measurements), we find that the majority of the emission is very compact: a high fraction (~80%) of the total line and continuum flux is associated with a region 1–1.5 kpc in diameter. The remaining ~20% of the emission is distributed over a larger area with radius lesssim4 kpc. The [C ii] emission does not exhibit ordered motion on kiloparsec scales: applying the virial theorem yields an upper limit on the dynamical mass of the host galaxy of $(4.3\pm 0.9)\times {10}^{10}$ ${M}_{\odot }$, only ~20 × higher than the central black hole (BH). The other targeted lines (CO(2–1), CO(7–6), and [C i]) are not detected, but the limits of the line ratios with respect to the [C ii] emission imply that the heating in the quasar host is dominated by star formation, and not by the accreting BH. The star formation rate (SFR) implied by the FIR continuum is 105–340 ${M}_{\odot }\,{\mathrm{yr}}^{-1}$, with a resulting SFR surface density of ~100–350 ${M}_{\odot }\,{\mathrm{yr}}^{-1}$ kpc−2, well below the value for Eddington-accretion-limited star formation

A Similarity Measure for GPU Kernel Subgraph Matching

Accelerator architectures specialize in executing SIMD (single instruction, multiple data) in lockstep. Because the majority of CUDA applications are parallelized loops, control flow information can provide an in-depth characterization of a kernel. CUDAflow is a tool that statically separates CUDA binaries into basic block regions and dynamically measures instruction and basic block frequencies. CUDAflow captures this information in a control flow graph (CFG) and performs subgraph matching across various kernel's CFGs to gain insights to an application's resource requirements, based on the shape and traversal of the graph, instruction operations executed and registers allocated, among other information. The utility of CUDAflow is demonstrated with SHOC and Rodinia application case studies on a variety of GPU architectures, revealing novel thread divergence characteristics that facilitates end users, autotuners and compilers in generating high performing code

Radiation reaction and energy-momentum conservation

We discuss subtle points of the momentum balance for radiating particles in flat and curved space-time. An instantaneous balance is obscured by the presence of the Schott term which is a finite part of the bound field momentum. To establish the balance one has to take into account the initial and final conditions for acceleration, or to apply averaging. In curved space-time an additional contribution arises from the tidal deformation of the bound field. This force is shown to be the finite remnant from the mass renormalization and it is different both form the radiation recoil force and the Schott force. For radiation of non-gravitational nature from point particles in curved space-time the reaction force can be computed substituting the retarded field directly to the equations of motion. Similar procedure is applicable to gravitational radiation in vacuum space-time, but fails in the non-vacuum case. The existence of the gravitational quasilocal reaction force in this general case seems implausible, though it still exists in the non-relativistic approximation. We also explain the putative antidamping effect for gravitational radiation under non-geodesic motion and derive the non-relativistic gravitational quadrupole Schott term. Radiation reaction in curved space of dimension other than four is also discussedComment: Lecture given at the C.N.R.S. School "Mass and Motion in General Relativity", Orleans, France, 200

Nonlinear Impurity Modes in Homogeneous and Periodic Media

We analyze the existence and stability of nonlinear localized waves described by the Kronig-Penney model with a nonlinear impurity. We study the properties of such waves in a homogeneous medium, and then analyze new effects introduced by periodicity of the medium parameters. In particular, we demonstrate the existence of a novel type of stable nonlinear band-gap localized states, and also reveal an important physical mechanism of the oscillatory wave instabilities associated with the band-gap wave resonances.Comment: 11 pages, 3 figures; To be published in: Proceedings of the NATO Advanced Research Workshop "Nonlinearity and Disorder: Theory and Applications" (Tashkent, 2-6 Oct, 2000) Editors: P.L. Christiansen and F.K. Abdullaev (Kluwer, 2001

Adding control to arbitrary unknown quantum operations

While quantum computers promise significant advantages, the complexity of quantum algorithms remains a major technological obstacle. We have developed and demonstrated an architecture-independent technique that simplifies adding control qubits to arbitrary quantum operations-a requirement in many quantum algorithms, simulations and metrology. The technique is independent of how the operation is done, does not require knowledge of what the operation is, and largely separates the problems of how to implement a quantum operation in the laboratory and how to add a control. We demonstrate an entanglement-based version in a photonic system, realizing a range of different two-qubit gates with high fidelity.Comment: 9 pages, 8 figure

Quality control of the sheep bacterial artificial chromosome library, CHORI-243

<p>Abstract</p> <p>Background</p> <p>The sheep CHORI-243 bacterial artificial chromosome (BAC) library is being used in the construction of the virtual sheep genome, the sequencing and construction of the actual sheep genome assembly and as a source of DNA for regions of the genome of biological interest. The objective of our study is to assess the integrity of the clones and plates which make up the CHORI-243 library using the virtual sheep genome.</p> <p>Findings</p> <p>A series of analyses were undertaken based on the mapping the sheep BAC-end sequences (BESs) to the virtual sheep genome. Overall, very few plate specific biases were identified, with only three of the 528 plates in the library significantly affected. The analysis of the number of tail-to-tail (concordant) BACs on the plates identified a number of plates with lower than average numbers of such BACs. For plates 198 and 213 a partial swap of the BESs determined with one of the two primers appear to have occurred. A third plate, 341, also with a significant deficit in tail-to-tail BACs, appeared to contain a substantial number of sequences determined from contaminating eubacterial 16 S rRNA DNA. Additionally a small number of eubacterial 16 S rRNA DNA sequences were present on two other plates, 111 and 338, in the library.</p> <p>Conclusions</p> <p>The comparative genomic approach can be used to assess BAC library integrity in the absence of fingerprinting. The sequences of the sheep CHORI-243 library BACs have high integrity, especially with the corrections detailed above. The library represents a high quality resource for use by the sheep genomics community.</p

Transmission of Foot-and-Mouth Disease SAT2 Viruses at the Wildlife-Livestock Interface of Two Major Transfrontier Conservation Areas in Southern Africa.

Over a decade ago, foot-and-mouth disease (FMD) re-emerged in Southern Africa specifically in beef exporting countries that had successfully maintained disease-free areas in the past. FMD virus (FMDV) serotype SAT2 has been responsible for a majority of these outbreaks. Epidemiological studies have revealed the importance of the African buffalo as the major wildlife FMD reservoir in the region. We used phylogeographic analysis to study dynamics of FMD transmission between buffalo and domestic cattle at the interface of the major wildlife protected areas in the region currently encompassing two largest Transfrontier conservation areas: Kavango-Zambezi (KAZA) and Great Limpopo (GL). Results of this study showed restricted local occurrence of each FMDV SAT2 topotypes I, II, and III, with occasional virus migration from KAZA to GL. Origins of outbreaks in livestock are frequently attributed to wild buffalo, but our results suggest that transmission from cattle to buffalo also occurs. We used coalescent Bayesian skyline analysis to study the genetic variation of the virus in cattle and buffalo, and discussed the association of these genetic changes in the virus and relevant epidemiological events that occurred in this area. Our results show that the genetic diversity of FMDV SAT2 has decreased in buffalo and cattle population during the last decade. This study contributes to understand the major dynamics of transmission and genetic variation of FMDV SAT2 in Southern Africa, which will could ultimately help in designing efficient strategies for the control of FMD at a local and regional level

Water Contaminants Associated With Unconventional Oil and Gas Extraction Cause Immunotoxicity to Amphibian Tadpoles

Chemicals associated with unconventional oil and gas (UOG) operations have been shown to contaminate surface and ground water with a variety of endocrine disrupting compounds (EDCs) inducing multiple developmental alteration in mice. However, little is known about the impacts of UOG-associated contaminants on amphibian health and resistance to an emerging ranavirus infectious disease caused by viruses in the genus Ranavirus, especially at the vulnerable tadpole stage. Here we used tadpoles of the amphibian Xenopus laevis and the ranavirus Frog virus 3 (FV3) as a model relevant to aquatic environment conservation research for investigating the immunotoxic effects of exposure to a mixture of 23 UOG-associated chemicals with EDC activity. Xenopus tadpoles were exposed to an equimass mixture of 23 UOG-associated chemicals (range from 0.1 to 10 µg/l) for 3 weeks prior to infection with FV3. Our data show that exposure to the UOG chemical mixture is toxic for tadpoles at ecological doses of 5 to 10 µg/l. Lower doses significantly altered homeostatic expression of myeloid lineage genes and compromised tadpole responses to FV3 through expression of TNF-α, IL-1β, and Type I IFN genes, correlating with an increase in viral load. Exposure to a subset of 6 UOG chemicals was still sufficient to perturb the antiviral gene expression response. These findings suggest that UOG-associated water pollutants at low but environmentally relevant doses have the potential to induce acute alterations of immune function and antiviral immunity