7 research outputs found
Short term serum pharmacokinetics of diammine silver fluoride after oral application
- Author
- A Rosenblatt
- A Wadhera
- ABG Lansdown
- ATSDR
- AV Ritter
- BY Liu
- CH Chu
- D Pl
- Donald R Taves
- DR Taves
- DR Taves
- EA MartĂnez-Mier
- EA Thibodeau
- Edgar Chirinos
- EJ Jensen
- Elsa Vasquez
- F de Almeida Lde
- FDA
- Gene E Watson
- GF Nordberg
- GM Knight
- Graciela Zegarra
- HJ Benson
- HP Tan
- IRIS: U.S. Environmental Protection Agency Integrated Risk Information System
- J Castillo
- J Ekstrand
- J Tanzer
- Jorge L Castillo
- JS Rees
- LE Gaul
- Lloyd L Mancl
- MC Fung
- NM Fisher
- Peter Milgrom
- R Sara
- R Shrestha
- RB Thurman
- Russell Dills
- SM Mirasattari
- T Gotjamanos
- WR Buckley
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Acute juvenile Paracoccidioidomycosis: A 9-year cohort study in the endemic area of Rio de Janeiro, Brazil
- Author
- AC Do Valle
- AC Do Valle
- AL Bocca
- AL Colombo
- AMM Paniago
- Andréa Gina Varon
- Anselmo Rocha RomĂŁo
- Antonio Carlos Francesconi do Valle
- Ariane Gomes PaixĂŁo
- B Wanke
- Claudia Vera Pizzini
- Dayvison Francis Saraiva Freitas
- E Cazzo
- F Francesconi
- F Queiroz-Telles
- G Benard
- GC Machado
- GR Isolan
- HC de Oliveira
- IM Siqueira
- J Batista Jr
- Joseph M. Vinetz
- LR Fabris
- LV Barrozo
- M Prado
- MA Shikanai-Yasuda
- MA Shikanai-Yasuda
- MM Teixeira
- MM Teixeira
- MR Fortes
- MSM Vidal
- P Queiroz JĂșnior Lde
- PM de Macedo
- PM Macedo
- Priscila Marques de Macedo
- R Chojniak
- R Quagliato Junior
- RC Hahn
- RL Mamoni
- Rodrigo Almeida-Paes
- Rosely Maria Zancopé-Oliveira
- RP Mendes
- SA Marques
- SH Marques-da-Silva
- ZF Coutinho
- ZF Coutinho
- Ziadir Francisco Coutinho
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Potential new clinical therapies for Chagas disease
- Author
- Apt W
- Araujo MS
- Aripirala S
- Atwood JA
- Baker SJ
- Barr SC
- Batista Dda G
- Bergstrom JD
- Bouzahzah B
- Brak K
- Buckner FS
- Buckner FS
- Bustamante JM
- Bustamante JM
- Castro JA
- Cencig S
- Collins MH
- Corrales M
- de Almeida EA
- de Oliveira RB
- Demoro B
- Diniz Lde F
- Docampo R
- Dybul M
- Fauro R
- Ferraz ML
- Freymann DM
- Gallerano RR
- Garzoni LR
- Gobbi P
- Gobbi P
- Grosso NL
- Gunatilleke SS
- Hall BS
- Hotez PJ
- Hudock MP
- Jacobs RT
- Jacobs RT
- Juan M Bustamante
- Kraus JM
- Lepesheva GI
- Lienhardt C
- Lo Presti MS
- Manne J
- McKerrow JH
- Medrano FJ
- Meiering S
- Minning TA
- Moreira da Silva R
- Navarro M
- Ndao M
- Nicoll-Griffith DA
- Papadopoulou MV
- Papadopoulou MV
- Papadopoulou MV
- Paulino M
- Raether W
- Rassi A
- Rassi A
- Raviolo MA
- Recher M
- Reithinger R
- Rick L Tarleton
- Rivarola HW
- Rodrigues-Poveda CA
- Rodriguez A
- Rodriques Coura J
- Rohmer M
- Sanz-Rodriguez CE
- Schmidt A
- Seiradake E
- Soeiro Mde N
- Toledo MJ
- Urbina JA
- Urbina JA
- Villalta F
- Viotti R
- Walton MI
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Photodynamic Therapy in Endodontics
- Author
- Aronoff BL.
- Athar M Mukhtar H, Bickers DR.
- Barthel CR Levin LG, Reisner HM, Trope M.
- Bettina B.,
- Bhatti M MacRobert A, Meghji S, Henderson B, Wilson M.
- Bidar M Hooshiar S, Naderinasab M, Moazzami M, Orafaee H, Naghavi N, Jafarzadeh H.
- Burns T Wilson M, Pearson GJ.
- Chan Y Lai CH.
- Dai T Huang YY, Hamblin MR.
- de Oliveira RR Novaes AB Jr, Garlet GP, de Souza RF, Taba M Jr, Sato S, de Souza SL, Palioto DB, Grisi MF, Feres M.
- de Oliveira RR Schwartz-Filho HO, Novaes AB Jr, Taba M Jr.
- Fernandes LA de Almeida JM, Theodoro LH, Bosco AF, Nagata MJ, Martins TM, Okamoto T, Garcia VG.
- Garcez AS Nuñez SC, Hamblim MR, Suzuki H, Ribeiro MS.
- Garcez AS Nuñez SC, Hamblin MR, Ribeiro MS.
- Garcez AS NĂșñez SC, Baptista MS, Daghastanli NA, Itri R, Hamblin MR, Ribeiro MS.
- George S Kishen A.
- George S Kishen A.
- Giroldo LM Felipe MP, de Oliveira MA, Munin E, Alves LP, Costa MS.
- Goulart Rde C Thedei G Jr, Souza SL, Tedesco AC, Ciancaglini P.
- Gursoy H Ozcakir-Tomruk C, Tanalp J, Yilmaz S.
- Hamblin MR Hasan T.
- Jackson Z Meghji S, Macrobert A, Henderson B, Wilson M.
- Johns DA Shivashankar VY, Krishnamma S, Johns M.
- Jori G Fabris C, Soncin M, Ferro S, Coppellotti O, Dei D, Fantetti L, Chiti G, Roncucci G.
- Kakehashi S Stanley HR, Fitzgerald RJ.
- Konopka K Goslinski T.
- Meire MA De Prijck K, Coenye T, Nelis HJ, De Moor RJ.
- Meisel P Kocher T.
- Moan J Peng Q.
- Mohammadi Z Abbott PV.
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- Mohammadi Z Dummer PM.
- Mohammadi Z Jafarzadeh H, Shalavi S.
- Mohammadi Z Shalavi S, Jafarzadeh H.
- Mohammadi Z.
- Möller AJ.
- Nagata JY Hioka N, Kimura E, Batistela VR, Terada RS, Graciano AX, Baesso ML, Hayacibara MF.
- Ochsner M.
- Ok E Ertas H, Saygili G, Gok T.
- Pfitzner A Sigusch BW, Albrecht V, Glockmann E.
- Prates RA Yamada AM, Suzuki LC, França CM, Cai S, Mayer MP, Ribeiro AC, Ribeiro MS.
- Redmond RW Gamlin JN.
- Sarkar S Wilson M.
- Sculean A Aoki A, Romanos G, Schwarz F, Miron RJ, Cosgarea R.
- Shrestha A Cordova M, Kishen A.
- Soares BM Alves OA, Ferreira MV, Amorim JC, Sousa GR, Silveira Lde B, Prates RA, Avila TV, Baltazar Lde M, de Souza Dda G, et al.
- Soares BM da Silva DL, Sousa GR, Amorim JC, de Resende MA, Pinotti M, Cisalpino PS.
- Soukos NS Chen PS, Morris JT, Ruggiero K, Abernethy AD, Som S, Foschi F, Doucette S, Bammann LL, Fontana CR, et al.
- Sundqvist G.
- Usacheva MN Teichert MC, Biel MA.
- Vohra F Akram Z, Safii SH, Vaithilingam RD, Ghanem A, Sergis K, Javed F.
- Wainwright M Giddens RM.
- Wainwright M Phoenix DA, Gaskell M, Marshall B.
- Wainwright M.
- Williams JA Pearson GJ, Colles MJ, Wilson M.
- Williams JA Pearson GJ, Colles MJ.
- Wilson M.
- Zeina B Greenman J, Purcell WM, Das B.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Resilon: Review of a New Material for Obturation of the Canal
- Author
- Al-Hadlaq SM Al-Jamhan A, Alsaeed T.
- Aptekar A Ginnan K.
- Attam K Talwar S.
- Azar M Khojastehpour L, Iranpour N.
- Baba SM Grover SI, Tyagi V.
- Barnett F Trope M.
- Baumgartner G Zehnder M, Paqué F.
- Biggs SG Knowles KI, Ibarrola JL, Pashley DH.
- Bodrumlu E Alaçam T.
- Bodrumlu E Muglali M, Sumer M, Guvenc T.
- Bodrumlu E Parlak E, Bodrumlu EH.
- Bodrumlu E Tunga U, Alaçam T.
- Bodrumlu E Tunga U.
- Bodrumlu E Tunga U.
- Bodrumlu E Uzun O, Topuz O, Semiz M.
- Cecchin D Souza M, Carlini-JĂșnior B, Barbizam JV.
- Chadha R Taneja S, Kumar M, Gupta S.
- Cunha RS De Martin AS, Barros PP, da Silva FM, Jacinto Rde C, Bueno CE.
- de Almeida-Gomes F Maniglia-Ferreira C, de Morais Vitoriano M, et al.
- de Oliveira DP Barbizam JV, Trope M, Teixeira FB.
- De-Deus G Namen F, Galan J Jr, Zehnder M.
- De-Deus G Namen F, Galan J.
- Donadio M Jiang J, He J, Wang YH, Safavi KE, Zhu Q.
- Dumani A Yoldas O, Isci AS, Köksal F, Kayar B, Polat E.
- Economides N Koulaouzidou EA, Gogos C, Kolokouris I, Beltes P, Antoniades D.
- Ezzie E Fleury A, Solomon E, Spears R, He J.
- Faria-JĂșnior NB Loiola LE, Guerreiro-Tanomaru JM, Berbert FL, Tanomaru-Filho M.
- Fenoul G Meless GD, PĂ©rez F.
- Fisher MA Berzins DW, Bahcall JK.
- Fransen JN He J, Glickman GN, Rios A, Shulman JD, Honeyman A.
- Garcia Lda F Marques AA, Roselino Lde M, Pires-de-Souza Fde C, Consani S.
- Gatewood RS.
- Gesi A Raffaelli O, Goracci C, Pashley DH, Tay FR, Ferrari M.
- Gogos C Theodorou V, Economides N, Beltes P, Kolokouris I.
- Gomes BP Berber VB, Montagner F, et al.
- Grande NM Plotino G, Lavorgna L, et al.
- Hammad M Qualtrough A, Silikas N.
- Hanada T Quevedo CG, Okitsu M, et al.
- Hassanloo A Watson P, Finer Y, Friedman S.
- Hemalatha H Sandeep M, Kulkarni S, Yakub SS.
- Hirai VH da Silva Neto UX, Westphalen VP, Perin CP, Carneiro E, Fariniuk LF.
- Iizuka N Takenaka S, Shigetani Y, Okiji T.
- Jack RM Goodell GG.
- Kangarlou A Dianat O, Esfahrood ZR, Asharaf H, Zandi B, Eslami G.
- Karabucak B Kim A, Chen V, Iqbal MK.
- Karapinar-KazandaĂ° M Tanalp J, Bayrak OF, Sunay H, Bayirli G.
- Kaya BU Keçeci AD, Belli S.
- Kocak MM Er O, Saglam BC, Yaman S.
- Kokorikos I Kolokouris I, Economides N, Gogos C, Helvatjoglu-Antoniades M.
- Kqiku L Miletic I, Gruber HJ, Anic I, StÀdtler P.
- Kqiku L StÀdtler P, Gruber HJ, Baraba A, Anic I, Miletic I.
- Kumar N Aggarwal V, Singla M, Gupta R.
- Leonardo MR Barnett F, Debelian GJ, de Pontes Lima RK, Bezerra da Silva LA,
- Lyons WW Hartwell GR, Stewart JT, Reavley B, Appelstein C, Lafkowitz S.
- Maltezos C Glickman GN, Ezzo P,
- Marfisi K Mercade M, Plotino G, Duran-Sindreu F, Bueno R, Roig M.
- Merdad K Pascon AE, Kulkarni G, Santerre P, Friedman S.
- Mohammadi Z Khademi A.
- Monteiro J de Ataide Ide N, Chalakkal P, Chandra PK.
- Monticelli F Osorio R, Toledano M, Ferrari M, Pashley DH, Tay FR.
- Nagas E Cehreli ZC, Durmaz V, Vallittu PK, Lassila LV.
- Oddoni PG Mello I, Coil JM, Antoniazzi JH.
- Onay EO Ungor M, Orucoglu H.
- Onay EO Ungor M, Ozdemir BH.
- Paque F Sirtes G.
- Pasqualini D Scotti N, Mollo L, et al.
- Pasqualini D Scotti N, Mollo L, et al.
- Pawiñska M Kierklo A, Tokajuk G, Sidun J.
- Pitout E Oberholzer TG, Blignaut E.
- Punia SK Nadig P, Punia V.
- Raina R Loushine RJ, Weller RN, Tay FR, Pashley DH.
- Resende LM Rached FJ Jr, Versiani MA, et al.
- Ribeiro FC Souza-Gabriel AE, Marchesan MA, Alfredo E, Silva-Sousa YT, Sousa-Neto MD.
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- Royal MJ Williamson AE, Drake DR.
- Sagsen B Er O, Kahraman Y, Akdogan G.
- Santos J TjÀderhane L, Ferraz C, et al.
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- Shashidhar C Shivanna V, Shivamurthy G, Shashidhar J.
- Shemesh H Souza EM, Wu MK, Wesselink PR.
- Shin SJ Jee SW, Song JS, Jung IY, Cha JH, Kim E.
- Shipper G Ărstavik D, Teixeira FB, Trope M.
- Shokouhinejad N Sabeti MA, Hasheminasab M, Shafiei F, Shamshiri AR.
- Shokouhinejad N Sharifian MR, Jafari M, Sabeti MA.
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- Skidmore LJ Berzins DW, Bahcall JK.
- Sly MM Moore BK, Platt JA, Brown CE.
- Somma F Cammarota G, Plotino G, Grande NM, Pameijer CH.
- Stratton RK Apicella MJ, Mines P.
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- Tanomaru-Filho M Orlando TA, Bortoluzzi EA, Silva GF, Tanomaru JM.
- Tay FR Loushine RJ, Weller RN, et al.
- TaĂŸdemir T Yildirim T, Celik D.
- Teixeira FB Teixeira EC, Thompson JY, Trope M.
- Ulusoy ĂĂ NayĂœr Y, Darendeliler-Yaman S.
- Ungor M Onay EO, Orucoglu H.
- Ureyen Kaya B Keçeci AD, Orhan H, Belli S.
- Wang CS Debelian GJ, Teixeira FB.
- Wedding JR Brown CE, Legan JJ, Moore BK, Vail MM.
- Wilkinson KL Beeson TJ, Kirkpatrick TC.
- Williamson AE Marker KL, Drake DR, Dawson DV, Walton RE.
- Zand V Salem-Milani A, Shahi S, Akhi MT, Vazifekhah S.
- Zarei M Shahrami F, Vatanpour M.
- Zmener O Pameijer CH, Serrano SA, Vidueira M, Macchi RL.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Cardiorenal end points in a trial of aliskiren for type 2 diabetes.
- Author
- Abe N
- Abedini S
- Abraham G
- Acker KV
- Adelberger V
- Adhikari P
- Agarwal N
- Ahmed F
- Aiello A
- Aizemberg D
- Aldigier JC
- Allemann Y
- Allison J 3rd
- Almeida F
- Altes U
- Altschuller A
- Amod A
- Anderson J
- Andre I
- Aniko S
- Antepara N
- Aoki S
- Arakaki R
- Aranda P
- Arango JL
- Araz M
- Arez L
- Arici M
- Armario P
- Arnouts P
- Aronson R
- Ates K
- Aucello G
- Azize GM
- Bacariza M
- Badariene J
- Baggen MG
- Bajaj M
- Bakker RC
- Bako B
- Banerjee D
- Bantwal G
- Barima YT
- Barranco E
- Barrera C
- Barrett B
- Barrios V
- Bartolacci I
- Batt R
- Bazzi A
- Beacom M
- Behnke T
- Belobradkova J
- Benacka J
- Berg J
- Berlingieri JC
- Berrizbeitia M
- Bevilacqua MT
- Bhana SA
- Bhattacharyya A
- Bianda T
- Bieler T
- Biernacki W
- Bilazarian S
- Bilous R
- Birne R
- Blacher J
- Blakney E
- Blanco D
- Boermans T
- Bonora E
- Botero R
- Botero R
- Bowden R
- Bowering K
- Branco P
- Brandao A
- Brandstetter R
- Brath H
- Braun RK
- Brenner BM
- Bressler P
- Brotons C
- Brown C
- Browne D
- Brunel P
- Bulliard C
- Burkhardt F
- Burnier M
- Burstein D
- Busch R
- Busick E
- Cabrera W
- Calatola P
- Calle A
- Calvert J
- Calvi\uf1o J
- Calvo C
- Capuano V
- Carillo E
- Carrillo E
- Carugo S
- Carvalho D
- Casalla F
- Casas L
- Catelao AM
- Catena C
- Cerasola G
- Cha D
- Cha J
- Chae D
- Chanchairujira T
- Charles H
- Charpentier G
- Chaturvedi N
- Chen HC
- Chen J
- Chen SC
- Chen X
- Cho W
- Chou CW
- Chouinard G
- Chowdhury S
- Christiansen JS
- Christiansen JS
- Chua T
- Cifkova R
- Cifkova R
- Cocchi R
- Comas A
- Comlekci A
- Comlekci A
- Connery L
- Constam EN
- Cooperman M
- Corona V
- Corsi A
- Coucke F
- Cournoyer S
- Cozzolino D
- Craig W
- Culak J
- Cunha R
- Cusachs AR
- D'Angelo AR
- D'Ospina A
- D\uf6m\uf6t\uf6r E
- da Costa AG
- da Silva GF
- da Silva PM
- Dani S
- Darko D
- Dattani D
- David S
- de Jong A
- de Paula RB
- De Pellegrin A
- de Roa ER
- De Teresa E
- de Zeeuw D
- Deak L
- Del Prato S
- dell Valle MH
- Dellanna F
- Demetry K
- Demirbas B
- Dendale P
- Desai AS
- Desai V
- Dharmalingam M
- Diaz M
- Dohnalova L
- Dong J
- Dotta F
- Downey H
- Drexel H
- Dudas M
- Dukat A
- Dukat A
- Dunselman PH
- Duprez D
- Dzuponova J
- East C
- Eavis P
- Egstrup K
- Eiam-Ong S
- Eickhoff F
- Ekoe JM
- Eng G
- Fabryova L
- Fagan T
- Falcone C
- Fanti P
- Farias E
- Fauvel JP
- Federici M
- Feenstra HJ
- Feis WL
- Feitosa G
- Felicio J
- Feng W
- Fern\ue1ndez-Cruz A
- Fernandez G
- Fernandez P
- Fernandez VL
- Ferri C
- Fery F
- Fiesselmann A
- Filetti S
- Filipova S
- Fisher M
- Fitz-Patrick D
- Foeger B
- Fogari R
- Forti A
- Fraile B
- Francesconi C
- Franco C
- Franke F
- Freedman Z
- Frisinghelli A
- Frontoni S
- Fu J
- Fucili A
- Fujita H
- Fukui T
- Fulop T
- Furuland H
- Gaal LV
- Gabriel J
- Gaillard CA
- Galceran JM
- Gallen I
- Gambardella S
- Garceau C
- Garcia JC
- Garcia M
- Garcia S
- Gerber P
- Gero L
- Gessner S
- Ghigo E
- Gil DV
- Gilbert J
- Giordano C
- Glorioso N
- Gnudi L
- Godin C
- Goebel R
- Gomez P
- Gonzalez JM
- Gonzalez R
- Gorson D
- Gorton S
- Gouet D
- Goumenos D
- Graf HJ
- Grandaliano G
- Gregoor PJ
- Grimm R
- Groeschel A
- Groeschel W
- Gronert J
- Groop PH
- Gu S
- Guarnieri A
- Gudnason S
- Guevara L
- Guija E
- Guneri S
- Gupta M
- Gurgun C
- Ha S
- Haack A
- Haase F
- Haffner SM
- Haller H
- Haller H
- Hanefeld M
- Hardin P
- Harris SB
- Hart T
- Harvey J
- Hayoz D
- He R
- Heeg JE
- Helin K
- Hernandez E
- Hernandez F
- Herrada B
- Herrmann HJ
- Hevendehl G
- Hilgenberg J
- Hiremath J
- Hissa MN
- Hohenstatt T
- Hollanders G
- Hominal M
- Hong T
- Horowitz B
- Ibrik O
- Iglesias FE
- Iglesias JN
- Ioannidis G
- Ipp E
- Isart J
- Istad H
- Itou T
- Iwaita Y
- Jacqmein J
- Jamerson K
- Jamerson K
- Jaramillo C
- Jardine A
- Ji Q
- Jia W
- Jimenez ML
- Jorde R
- Jorde R
- Juhl H
- Juncos L
- Juncos L
- Kaasjager HA
- Kajiyama S
- Kalender B
- Kananen K
- Kaneko S
- Kang S
- Kapocsi J
- Kasahara H
- Katayama SS
- Katz L
- Kawahara K
- Ke Y
- Kerrane J
- Kerstein H
- Khandwala H
- Kilbane A.
- Kim S
- Kim S
- Kim SG
- Kim Y
- Kim Y
- Kiss I
- Kitiyakara C
- Klaff L
- Klausmann G
- Klepzig C
- Koc M
- Kocourkova B
- Koeper D
- Kojima S
- Koleny D
- Komroskova M
- Kooy A
- Kooy A
- Kopyt NP
- Koranyi L
- Kovalchuck AA
- Krapf R
- Krieger E
- Krishnan U
- Krzesinski JM
- Kumar J
- Kumar S
- Kuschnir E
- Kvapil M
- Kwak I
- Kwon Y
- Labutiniene IP
- Lachance P
- Lachin JM
- Lahtela J
- Lambiase C
- Lanier D
- Larnefelt H
- Lasala G
- Lau T
- Ledger G
- Lee CT
- Leendert RJ
- Lehmann G
- Leimbach W
- Leira VM
- Leiter L
- Leiter L
- Lema L
- Lembo G
- Lengyel Z
- Leotta S
- Lerman S
- Lervang HH
- Leurs PB
- Levenson D
- Levinson L
- Li H
- Li L
- Li Q
- Li Q
- Li\ue9nart F
- Lieverse AG
- Lim C
- Limone PP
- Lin H
- Lin SH
- Lipetz R
- Litchfield J
- Litwak L
- Liu B
- Liu X
- Liu Z
- Locatelli F
- Lock J
- Lok D
- Lok DJ
- Lopez A
- Lopez I
- Lopez JM
- Lopez R
- Lu J
- Luik AJ
- Lund R
- Lv X
- Ma J
- Maddux A
- Maeda Y
- Maggioni A
- Maglia G
- Majul C
- Makan H
- Maltezos E
- Mamish Z
- Mancebo JG
- Mannarino E
- Marchionni N
- Marechaud R
- Margulis F
- Marin M
- Marre M
- Marre M
- Martin D
- Martin E
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- Martin J
- Martinez F
- Martinez J
- Martinez V
- Martinka E
- Martins L
- Massari P
- Mateos C
- Mathieu C
- Matsubayashi S
- Matsumoto A
- Mayer G
- McGill J
- McMurray JJ
- Mediavilla JD
- Medina B
- Medina F
- Medina F
- Meeus G
- Mei C
- Mendez R
- Merke J
- Mersey J
- Michael S
- Middleton A
- Migdalis I
- Miglinas M
- Milesi R
- Minehart C
- Mion D Jr
- Moccetti T
- Modi KK
- Mohan V
- Monta\uf1a O
- Monterroso V
- Morosetti M
- Mos L
- Mostard G
- Moustafa M
- Mueller G
- Muirhead N
- Munger R
- Muros T
- Nadal JJ
- Naicker P
- Nanclares MS
- Narayan P
- Narimiya M
- Ng TG
- Nickenig G
- Nickenig G
- Nicolaides M
- Niepen PV
- Nierop PR
- Nolen T
- Nour K
- Novo S
- Nyirati G
- O'Hare P
- Oerter E
- Oestergaard O
- Ogawa Y
- Oh H
- Oigman W
- Okamoto H
- Olivan J
- Olsen H
- Onishi Y
- Ontiveros C
- Ooi TC
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- Zinman B
- Zushi S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2012
- Field of study
BACKGROUND: This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both.
METHODS: In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level.
RESULTS: The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P=0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, 656 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P<0.001 for both comparisons).
CONCLUSIONS: The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful
Adhesive Bonding to Computer-aided Design/Computer-aided Manufacturing Esthetic Dental Materials: An Overview
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- Pereira Lde L Campos F, Dal Piva AM, Gondim LD, Souza RO, Ăzcan M.
- Peumans M Valjakova EB, De Munck J, Mishevska CB, Van Meerbeek B.
- Piascik JR Swift EJ, Braswell K, Stoner BR.
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- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study