24 research outputs found
Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides
Functionalized arylmagnesium halides, prepared via an iodineâmagnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN·2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities