1,016 research outputs found
Breaking Instance-Independent Symmetries In Exact Graph Coloring
Code optimization and high level synthesis can be posed as constraint
satisfaction and optimization problems, such as graph coloring used in register
allocation. Graph coloring is also used to model more traditional CSPs relevant
to AI, such as planning, time-tabling and scheduling. Provably optimal
solutions may be desirable for commercial and defense applications.
Additionally, for applications such as register allocation and code
optimization, naturally-occurring instances of graph coloring are often small
and can be solved optimally. A recent wave of improvements in algorithms for
Boolean satisfiability (SAT) and 0-1 Integer Linear Programming (ILP) suggests
generic problem-reduction methods, rather than problem-specific heuristics,
because (1) heuristics may be upset by new constraints, (2) heuristics tend to
ignore structure, and (3) many relevant problems are provably inapproximable.
Problem reductions often lead to highly symmetric SAT instances, and
symmetries are known to slow down SAT solvers. In this work, we compare several
avenues for symmetry breaking, in particular when certain kinds of symmetry are
present in all generated instances. Our focus on reducing CSPs to SAT allows us
to leverage recent dramatic improvement in SAT solvers and automatically
benefit from future progress. We can use a variety of black-box SAT solvers
without modifying their source code because our symmetry-breaking techniques
are static, i.e., we detect symmetries and add symmetry breaking predicates
(SBPs) during pre-processing.
An important result of our work is that among the types of
instance-independent SBPs we studied and their combinations, the simplest and
least complete constructions are the most effective. Our experiments also
clearly indicate that instance-independent symmetries should mostly be
processed together with instance-specific symmetries rather than at the
specification level, contrary to what has been suggested in the literature
Gene Expression in Experimental Aortic Coarctation and Repair: Candidate Genes for Therapeutic Intervention?
Coarctation of the aorta (CoA) is a constriction of the proximal descending thoracic aorta and is one of the most common congenital cardiovascular defects. Treatments for CoA improve life expectancy, but morbidity persists, particularly due to the development of chronic hypertension (HTN). Identifying the mechanisms of morbidity is difficult in humans due to confounding variables such as age at repair, follow-up duration, coarctation severity and concurrent anomalies. We previously developed an experimental model that replicates aortic pathology in humans with CoA without these confounding variables, and mimics correction at various times using dissolvable suture. Here we present the most comprehensive description of differentially expressed genes (DEGs) to date from the pathology of CoA, which were obtained using this model. Aortic samples (n=4/group) from the ascending aorta that experiences elevated blood pressure (BP) from induction of CoA, and restoration of normal BP after its correction, were analyzed by gene expression microarray, and enriched genes were converted to human orthologues. 51 DEGs with \u3e6 fold-change (FC) were used to determine enriched Gene Ontology terms, altered pathways, and association with National Library of Medicine Medical Subject Headers (MeSH) IDs for HTN, cardiovascular disease (CVD) and CoA. The results generated 18 pathways, 4 of which (cell cycle, immune system, hemostasis and metabolism) were shared with MeSH ID’s for HTN and CVD, and individual genes were associated with the CoA MeSH ID. A thorough literature search further uncovered association with contractile, cytoskeletal and regulatory proteins related to excitation-contraction coupling and metabolism that may explain the structural and functional changes observed in our experimental model, and ultimately help to unravel the mechanisms responsible for persistent morbidity after treatment for CoA
On a q-difference Painlev\'e III equation: I. Derivation, symmetry and Riccati type solutions
A q-difference analogue of the Painlev\'e III equation is considered. Its
derivations, affine Weyl group symmetry, and two kinds of special function type
solutions are discussed.Comment: arxiv version is already officia
Quasi-point separation of variables for the Henon-Heiles system and a system with quartic potential
We examine the problem of integrability of two-dimensional Hamiltonian
systems by means of separation of variables. The systematic approach to
construction of the special non-pure coordinate separation of variables for
certain natural two-dimensional Hamiltonians is presented. The relations with
SUSY quantum mechanics are discussed.Comment: 11 pages, Late
Multiple-scale analysis of discrete nonlinear partial difference equations: the reduction of the lattice potential KdV
We consider multiple lattices and functions defined on them. We introduce
slow varying conditions for functions defined on the lattice and express the
variation of a function in terms of an asymptotic expansion with respect to the
slow varying lattices.
We use these results to perform the multiple--scale reduction of the lattice
potential Korteweg--de Vries equation.Comment: 17 pages. 1 figur
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