Data for: Temporal, Spatial and Geochemical Evolution of Late Cenozoic Post-Subduction Magmatism in Central and Eastern Anatolia, Turkey

This study primarily relies on the compilation, integration and interpretation of published age and geochemical data from late Cenozoic igneous rocks in central and eastern Anatolia, Turkey. Most dates were obtained by K-Ar and 40Ar/39Ar dating techniques on igneous biotite, hornblende, feldspar, groundmass, and whole-rock material from volcanic rock samples. Those dates can be interpreted as crystallization ages, but are susceptible to alteration and partial to whole resetting, which may conspire to yield dates that may be too young. The previously-published lithogeochemical and Sr-Nd-Pb isotopic analyses from 28 late Cenozoic igneous units were carefully filtered to generate a working database. All of the analyses from altered or weathered samples, yielding a total volatile content (LOI) greater than 5 wt % and acquired from enclaves, cumulates or xenoliths were eliminated. Outlying compositions were discarded in order to increase the internal coherence of the database. Despite this screening procedure, the resultant database suffers from a lack of homogeneity, data control and analytical differences as analyses were obtained through different analytical packages including variable set of elements, instrument (XRF, ICP-MS, INAA, etc.) and dissolution methods (total fusion, aqua regia, etc.) from various laboratories (Bureau Veritas, ActLabs, ALS, universities, etc.). The report of Fe oxidation state in the literature suffers from some approximation despite a careful data compilation (e.g., Fe2O3, FeO, FeOt and Fe2O3t). Approximations also lie in sample age and location as this information is not always provided in the literature.Published Sr-Nd-Pb radiogenic isotope data were compiled from literature. We corrected the 87Sr/86Sr, 143Nd/144Nd, 206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb ratios to age to get initial isotopic ratios for those situations where the element concentration of Sr, Rb, Nd, Sm, Th, U and Pb was available. Most of the published Pb analyses were bracketed by the SRM981 standard. As reference values vary among publications, all the published Pb data were normalized to Galer and Abouchami (1998)

Data for: Temporal, Spatial and Geochemical Evolution of Late Cenozoic Post-Subduction Magmatism in Central and Eastern Anatolia, Turkey

This study primarily relies on the compilation, integration and interpretation of published age and geochemical data from late Cenozoic igneous rocks in central and eastern Anatolia, Turkey. Most dates were obtained by K-Ar and 40Ar/39Ar dating techniques on igneous biotite, hornblende, feldspar, groundmass, and whole-rock material from volcanic rock samples. Those dates can be interpreted as crystallization ages, but are susceptible to alteration and partial to whole resetting, which may conspire to yield dates that may be too young. The previously-published lithogeochemical and Sr-Nd-Pb isotopic analyses from 28 late Cenozoic igneous units were carefully filtered to generate a working database. All of the analyses from altered or weathered samples, yielding a total volatile content (LOI) greater than 5 wt % and acquired from enclaves, cumulates or xenoliths were eliminated. Outlying compositions were discarded in order to increase the internal coherence of the database. Despite this screening procedure, the resultant database suffers from a lack of homogeneity, data control and analytical differences as analyses were obtained through different analytical packages including variable set of elements, instrument (XRF, ICP-MS, INAA, etc.) and dissolution methods (total fusion, aqua regia, etc.) from various laboratories (Bureau Veritas, ActLabs, ALS, universities, etc.). The report of Fe oxidation state in the literature suffers from some approximation despite a careful data compilation (e.g., Fe2O3, FeO, FeOt and Fe2O3t). Approximations also lie in sample age and location as this information is not always provided in the literature.Published Sr-Nd-Pb radiogenic isotope data were compiled from literature. We corrected the 87Sr/86Sr, 143Nd/144Nd, 206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb ratios to age to get initial isotopic ratios for those situations where the element concentration of Sr, Rb, Nd, Sm, Th, U and Pb was available. Most of the published Pb analyses were bracketed by the SRM981 standard. As reference values vary among publications, all the published Pb data were normalized to Galer and Abouchami (1998).THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Typical medullary breast carcinomas have a basal/myoepithelial phenotype

Medullary breast cancer (MBC) is a rare, diagnostically difficult, pathological subtype. Despite being high grade, it has a good prognosis. MBC patients have an excess of BRCA1 germ-fine mutation and reliable identification of MBC could help to identify patients at risk of carrying germline BRCA1 mutations or in whom chemotherapy could be avoided. The aim of this study was therefore to improve diagnosis by establishing an MBC protein expression profile using immunohistochemistry (IHC) on tissue-microarrays (TMA). Using a series of 779 breast carcinomas ('EC' set), diagnosed initially as MBC, a double-reading session was carried out by several pathologists on all of the histological material to establish the diagnosis as firmly as possible using a 'medullary score'. Only MBCs with high scores, i.e. typical MBC (TMBC) (n = 44) and non-TMBC grade III with no or low scores (n = 160), were included in the IHC study. To validate the results obtained on this first set, a control series of TMBC (n = 17) and non-MBC grade III cases (n = 140) ('IPC' set) was studied. The expression of 18 proteins was studied in the 61 TMBCs and 300 grade III cases from the two sets. The global intra-observer concordance of the first reading for the diagnosis of TMBC was 94%, with almost perfect kappa (kappa) of 0.815. TMBC was characterized by a high degree of basal/myoepithelial differentiation. In multivariate analysis with logistic regression, TMBC was defined by the association of P-cadherin (R = 2.29), MIB1 > 50 (R = 3.80), ERBB2 negativity (R = 2.24) and p53 positivity (RR = 1.45). Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd