2 research outputs found
Regulatory RNAs in Heart Failure
Cardiovascular disease is an enormous socioeconomic burden worldwide and remains a leading cause of mortality and disability despite significant efforts to improve treatments and personalize healthcare. Heart failure is the main manifestation of cardiovascular disease and has reached epidemic proportions. Heart failure follows a loss of cardiac homeostasis, which relies on a tight regulation of gene expression. This regulation is under the control of multiple types of RNA molecules, some encoding proteins (the so-called messenger RNAs) and others lacking protein-coding potential, named noncoding RNAs. In this review article, we aim to revisit the notion of regulatory RNA, which has been thus far mainly confined to noncoding RNA. Regulatory RNA, which we propose to abbreviate as regRNA, can include both protein-coding RNAs and noncoding RNAs, as long as they contribute, directly or indirectly, to the regulation of gene expression. We will address the regulation and functional role of messenger RNAs, microRNAs, long noncoding RNAs, and circular RNAs (ie, regRNAs) in heart failure. We will debate the utility of regRNAs to diagnose, prognosticate, and treat heart failure, and we will provide directions for future work
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Final NOMAD results on muon-neutrino ---> tau-neutrino and electron-neutrino ---> tau-neutrino oscillations including a new search for tau-neutrino appearance using hadronic tau decays.
Results from the ?t appearance search in a neutrino beam using the full NOMAD data sample are reported. A new analysis unifies all the hadronic t decays, significantly improving the overall sensitivity of the experiment to oscillations. The “blind analysis” of all topologies yields no evidence for an oscillation signal. In the two-family oscillation scenario, this sets a 90% CL allowed region in the sin22?µt–?m2 plane which includes sin22?µt<3.3×10-4 at large ?m2 and ?m2< 0.7 eV2/c4 at sin22?µt=1. The corresponding contour in the ?e??t oscillation hypothesis results in sin22?et<1.5×10-2 at large ?m2 and ?m2<5.9 eV2/c4 at sin22?et=1. We also derive limits on effective couplings of the t lepton to ?µ or ?e