Control of apple scab by curative applications of biocontrol agents

In organic apple growing protective applications with copper, sulphur or lime sulphur are used for apple scab control. Protective applications have to be repeated when new leaves unfold. The timing of protective sprays depends on the weather forecast. If forecasted infection conditions fail to appear, treatments were for nothing. With curative control agents available, the number of treatments could be reduced. In greenhouse trials we tested control agents for their protective and curative efficiency against apple scab after artificial inoculation of potted apple trees. Applications were done 2 hours before inoculation, 5 hours after inoculation on wet leaves, 5 hours after inoculation during simulated rainfall or 24 hours after inoculation on wet or dry leaves. The optimal time of application differed between the preparations tested. Vitisan and OmniProtect had their highest activity when sprayed curative 24 hours after inoculation. Combinations were found, which revealed a high efficiency against apple scab from 2h before to 24 hours after inoculation. In a field trial apple scab was effectively controlled by curative applications of OmniProtect

Coherence-controlled transparency and far-from-degenerate parametric gain in a strongly-absorbing Doppler-broadened medium

An inversionless gain of anti-Stokes radiation above the oscillation threshold in an optically-dense far-from-degenerate double-Lambda Doppler-broadened medium accompanied by Stokes gain is predicted. The outcomes are illustrated with numerical simulations applied to sodium dimer vapor. Optical switching from absorption to gain via transparency controlled by a small variation of the medium and of the driving radiation parameters which are at a level less than one photon per molecule is shown. Related video/audio clips see in: A.K. Popov, S.A. Myslivets, and T.F. George, Optics Express Vol. 7, No 3, 148 (2000)(http://epubs.osa.org/oearchive/source/22947.htm) or download: http://kirensky.krasn.ru/popov/opa/opa.htmComment: 4 pages, 3 eps figures, to be published in Optics Letters, vol.25, No 18 (2000), minor style changes and reference correctio

On the Nature of Incompressible Magnetohydrodynamic Turbulence

A novel model of incompressible magnetohydrodynamic turbulence in the presence of a strong external magnetic field is proposed for explanation of recent numerical results. According to the proposed model, in the presence of the strong external magnetic field, incompressible magnetohydrodynamic turbulence becomes nonlocal in the sense that low frequency modes cause decorrelation of interacting high frequency modes from the inertial interval. It is shown that the obtained nonlocal spectrum of the inertial range of incompressible magnetohydrodynamic turbulence represents an anisotropic analogue of Kraichnan's nonlocal spectrum of hydrodynamic turbulence. Based on the analysis performed in the framework of the weak coupling approximation, which represents one of the equivalent formulations of the direct interaction approximation, it is shown that incompressible magnetohydrodynamic turbulence could be both local and nonlocal and therefore anisotropic analogues of both the Kolmogorov and Kraichnan spectra are realizable in incompressible magnetohydrodynamic turbulence.Comment: Physics of Plasmas (Accepted). A small chapter added about 2D MHD turbulenc

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

Impaired diastolic filling is a main contributor to heart failure with preserved ejection fraction (HFpEF), a syndrome with increasing prevalence and no treatment. Both collagen and the giant sarcomeric protein titin determine diastolic function. Since titin's elastic properties can be adjusted physiologically, we evaluated titin-based stiffness as a therapeutic target. We adjusted RBM20-dependent cardiac isoform expression in the titin N2B knockout mouse with increased ventricular stiffness. A ~50 % reduction of RBM20 activity does not only maintain cardiac filling in diastole but also ameliorates cardiac atrophy and thus improves cardiac function in the N2B-deficient heart. Reduced RBM20 activity partially normalized gene expression related to muscle development and fatty acid metabolism. The adaptation of cardiac growth was related to hypertrophy signaling via four-and-a-half lim-domain proteins (FHLs) that translate mechanical input into hypertrophy signals. We provide a novel link between cardiac isoform expression and trophic signaling via FHLs and suggest cardiac splicing as a therapeutic target in diastolic dysfunction. KEY MESSAGE: Increasing the length of titin isoforms improves ventricular filling in heart disease. FHL proteins are regulated via RBM20 and adapt cardiac growth. RBM20 is a therapeutic target in diastolic dysfunction

AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions.

AMPA receptor (AMPAR) abundance and positioning at excitatory synapses regulates the strength of transmission. Changes in AMPAR localisation can enact synaptic plasticity, allowing long-term information storage, and is therefore tightly controlled. Multiple mechanisms regulating AMPAR synaptic anchoring have been described, but with limited coherence or comparison between reports, our understanding of this process is unclear. Here, combining synaptic recordings from mouse hippocampal slices and super-resolution imaging in dissociated cultures, we compare the contributions of three AMPAR interaction domains controlling transmission at hippocampal CA1 synapses. We show that the AMPAR C-termini play only a modulatory role, whereas the extracellular N-terminal domain (NTD) and PDZ interactions of the auxiliary subunit TARP γ8 are both crucial, and each is sufficient to maintain transmission. Our data support a model in which γ8 accumulates AMPARs at the postsynaptic density, where the NTD further tunes their positioning. This interplay between cytosolic (TARP γ8) and synaptic cleft (NTD) interactions provides versatility to regulate synaptic transmission and plasticity

Non-linear Pattern Matching with Backtracking for Non-free Data Types

Non-free data types are data types whose data have no canonical forms. For example, multisets are non-free data types because the multiset $\{a,b,b\}$ has two other equivalent but literally different forms $\{b,a,b\}$ and $\{b,b,a\}$. Pattern matching is known to provide a handy tool set to treat such data types. Although many studies on pattern matching and implementations for practical programming languages have been proposed so far, we observe that none of these studies satisfy all the criteria of practical pattern matching, which are as follows: i) efficiency of the backtracking algorithm for non-linear patterns, ii) extensibility of matching process, and iii) polymorphism in patterns. This paper aims to design a new pattern-matching-oriented programming language that satisfies all the above three criteria. The proposed language features clean Scheme-like syntax and efficient and extensible pattern matching semantics. This programming language is especially useful for the processing of complex non-free data types that not only include multisets and sets but also graphs and symbolic mathematical expressions. We discuss the importance of our criteria of practical pattern matching and how our language design naturally arises from the criteria. The proposed language has been already implemented and open-sourced as the Egison programming language

Shear Effects in Non-Homogeneous Turbulence

Motivated by recent experimental and numerical results, a simple unifying picture of intermittency in turbulent shear flows is suggested. Integral Structure Functions (ISF), taking into account explicitly the shear intensity, are introduced on phenomenological grounds. ISF can exhibit a universal scaling behavior, independent of the shear intensity. This picture is in satisfactory agreement with both experimental and numerical data. Possible extension to convective turbulence and implication on closure conditions for Large-Eddy Simulation of non-homogeneous flows are briefly discussed.Comment: 4 pages, 5 figure

Stochastic Optimal Robin Boundary Control Problems of Advection-Dominated Elliptic Equations

In this work we deal with a stochastic optimal Robin boundary control problem constrained by an advection-diffusion-reaction elliptic equation with advection-dominated term. We assume that the uncertainty comes from the advection field and consider a stochastic Robin boundary condition as control function. A stochastic saddle point system is formulated and proved to be equivalent to the first order optimality system for the optimal control problem, based on which we provide the existence and uniqueness of the optimal solution as well as some results on stochastic regularity with respect to the random variables. Stabilized finite element approximations in physical space and collocation approximations in stochastic space are applied to discretize the optimality system. A global error estimate in the product of physical space and stochastic space for the numerical approximation is derived. Illustrative numerical experiments are provided. \ua9 2013 Society for Industrial and Applied Mathematics

Rotational Correlation Functions of Single Molecules

Single molecule rotational correlation functions are analyzed for several reorientation geometries. Even for the simplest model of isotropic rotational diffusion our findings predict non-exponential correlation functions to be observed by polarization sensitive single molecule fluorescence microscopy. This may have a deep impact on interpreting the results of molecular reorientation measurements in heterogeneous environments.Comment: 5 pages, 4 figure