35 research outputs found
Towards the classification of static vacuum spacetimes with negative cosmological constant
We present a systematic study of static solutions of the vacuum Einstein
equations with negative cosmological constant which asymptotically approach the
generalized Kottler (``Schwarzschild--anti-de Sitter'') solution, within
(mainly) a conformal framework. We show connectedness of conformal infinity for
appropriately regular such space-times. We give an explicit expression for the
Hamiltonian mass of the (not necessarily static) metrics within the class
considered; in the static case we show that they have a finite and well defined
Hawking mass. We prove inequalities relating the mass and the horizon area of
the (static) metrics considered to those of appropriate reference generalized
Kottler metrics. Those inequalities yield an inequality which is opposite to
the conjectured generalized Penrose inequality. They can thus be used to prove
a uniqueness theorem for the generalized Kottler black holes if the generalized
Penrose inequality can be established.Comment: the discussion of our results includes now some solutions of Horowitz
and Myers; typos corrected here and there; a shortened version of this
version will appear in Journal of Mathematical Physic
cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate regulation by the autonomic nervous system. We addressed this question using a knockin mouse line expressing cyclic adenosine monophosphate-insensitive HCN4 channels. This mouse line displayed a complex cardiac phenotype characterized by sinus dysrhythmia, severe sinus bradycardia, sinus pauses and chronotropic incompetence. Furthermore, the absence of CDR leads to inappropriately enhanced heart rate responses of the SAN to vagal nerve activity in vivo. The mechanism underlying these symptoms can be explained by the presence of nonfiring pacemaker cells. We provide evidence that a tonic and mutual interaction process (tonic entrainment) between firing and nonfiring cells slows down the overall rhythm of the SAN. Most importantly, we show that the proportion of firing cells can be increased by CDR of HCN4 to efficiently oppose enhanced responses to vagal activity. In conclusion, we provide evidence for a novel role of CDR of HCN4 for the central pacemaker process in the sinoatrial node
Change in obsessive beliefs as predictor and mediator of symptom change during treatment of obsessive-compulsive disorder – a process-outcome study
Citizen science’s transformative impact on science, citizen empowerment and socio-political processes
Citizen science (CS) can foster transformative impact for science, citizen empowerment and socio-political processes. To unleash this impact, a clearer understanding of its current status and challenges for its development is needed. Using quantitative indicators developed in a collaborative stakeholder process, our study provides a comprehensive overview of the current status of CS in Germany, Austria and Switzerland. Our online survey with 340 responses focused on CS impact through (1) scientific practices, (2) participant learning and empowerment, and (3) socio-political processes. With regard to scientific impact, we found that data quality control is an established component of CS practice, while publication of CS data and results has not yet been achieved by all project coordinators (55%). Key benefits for citizen scientists were the experience of collective impact (“making a difference together with others”) as well as gaining new knowledge. For the citizen scientists’ learning outcomes, different forms of social learning, such as systematic feedback or personal mentoring, were essential. While the majority of respondents attributed an important value to CS for decision-making, only few were confident that CS data were indeed utilized as evidence by decision-makers. Based on these results, we recommend (1) that project coordinators and researchers strengthen scientific impact by fostering data management and publications, (2) that project coordinators and citizen scientists enhance participant impact by promoting social learning opportunities and (3) that project initiators and CS networks foster socio-political impact through early engagement with decision-makers and alignment with ongoing policy processes. In this way, CS can evolve its transformative impact