Getting to the Heart of the Matter Evaluation Report: Post-Acute Cardiac Rehabilitation Program to Reduce Hospital Readmissions

Launched in 2013, this innovative program was designed to help cardiac patients achieve success with their post-acute treatment regime, something that is especially important for older cardiac patients who are at an increased risk for complications. By "bridging the gap" between when patients are discharged from acute care until they are ready to start outpatient cardiac rehabilitation, the program aims to improve the quality of care and quality of life for older adults recovering from congestive heart failure, myocardial infarction, bypass surgery, and other heart diseases and reduce hospital readmissions

Charging NOx Emitters for Health Damages: An Exploratory Analysis

We present a proof-of-concept analysis of the measurement of the health damage of ozone (O3) produced from nitrogen oxides (NOx = NO NO2) emitted by individual large point sources in the eastern United States. We use a regional atmospheric model of the eastern United States, the Comprehensive Air Quality Model with Extensions (CAMx), to quantify the variable impact that a fixed quantity of NOx emitted from individual sources can have on the downwind concentration of surface O3, depending on temperature and local biogenic hydrocarbon emissions. We also examine the dependence of resulting ozone-related health damages on the size of the exposed population. The investigation is relevant to the increasingly widely used "cap and trade" approach to NOx regulation, which presumes that shifts of emissions over time and space, holding the total fixed over the course of the summer O3 season, will have minimal effect on the environmental outcome. By contrast, we show that a shift of a unit of NOx emissions from one place or time to another could result in large changes in the health effects due to ozone formation and exposure. We indicate how the type of modeling carried out here might be used to attach externality-correcting prices to emissions. Charging emitters fees that are commensurate with the damage caused by their NOx emissions would create an incentive for emitters to reduce emissions at times and in locations where they cause the largest damage.

Monitoring pit and fissures using transparent sealant and fluorescence intraoral camera, 12 months follow up

The aim of this in vivo study is to report on the combined use of a fluorescence intraoral camera and transparent sealant for the clinical monitoring of pits and fissures. 96 permanent molars with a ICDAS II code 0, 1, or 2, (in 48 patients aged 12–14) were registered at the First Observation Unit (Oral and Maxillofacial Sciences Department), Sapienza University, Rome. Clinically selected teeth were double-checked using a VistaCam iX Proof (Durr Dental AG) and sealed with a transparent sealant (ControlSeal, VOCO GmbH), following the established indications for use if a pit and fissure condition was confirmed within the camera’s internal cutoff point of 1.5 (“early enamel demineralization”). Clinical followup was performed using VistaCam at 6 and 12 months to assess sealant retention and any demineralization trend. At baseline, 57.4% of the registered teeth were sound, both visually and when using the fluorescence camera, 42.6% presented an early demineralization (<1.5 with VistaCam and ICDAS II 1- 2). Subsequent VistaCam assessment of surfaces underlying the transparent sealant totally confirmed initial evaluations. Complete sealant retention rated 95% at 6 months, and 91% at 12 months. No case of complete detachment was observed. At the 12-month follow-up, VistaCam measurements resulted stable in the whole sample, except for one permanent molar, which presented a demineralization increment and partial sealant retention. Visual and fluorescence assessments were consistent and feasible. Incomplete sealant retention occurred in 5% of cases at 6 months and 9% of cases at 12 months and was probably due to procedure imperfections. The combined use of transparent sealant and a fluorescence camera shows clinical effectiveness and diagnostic efficacy for occlusal surface monitoring

Charging NOx Emitters for Health Damages: An Exploratory Analysis

We present a proof-of-concept analysis of the measurement of the health damage of ozone (O3) produced from nitrogen oxides (NOx = NO + NO2) emitted by individual large point sources in the eastern United States. We use a regional atmospheric model of the eastern United States, the Comprehensive Air Quality Model with Extensions (CAMx), to quantify the variable impact that a fixed quantity of NOx emitted from individual sources can have on the downwind concentration of surface O3, depending on temperature and local biogenic hydrocarbon emissions. We also examine the dependence of resulting ozone-related health damages on the size of the exposed population. The investigation is relevant to the increasingly widely used “cap and trade” approach to NOx regulation, which presumes that shifts of emissions over time and space, holding the total fixed over the course of the summer O3 season, will have minimal effect on the environmental outcome. By contrast, we show that a shift of a unit of NOx emissions from one place or time to another could result in large changes in the health effects due to ozone formation and exposure. We indicate how the type of modeling carried out here might be used to attach externality-correcting prices to emissions. Charging emitters fees that are commensurate with the damage caused by their NOx emissions would create an incentive for emitters to reduce emissions at times and in locations where they cause the largest damage.surface ozone, NOx emissions, point sources, health impacts, mortality, morbidity, cap-and-trade

Cosmogenic neutrinos and gamma-rays and the redshift evolution of UHECR sources

If ultra-high-energy cosmic rays (UHECRs) have extragalactic origins, as is widely assumed to be the case at least for the majority of cosmic rays with energies above a few EeV, secondary neutrinos and photons can be expected to be produced during the propagation of UHECRs through intergalactic space via interactions with cosmic background photons. The fluxes of such secondary particles are strongly dependent on the redshift evolution of the emissivity (number density times luminosity) of UHECR sources. We show how cosmic rays, neutrinos, and gamma rays can potentially provide complementary information about UHECR source evolution.Comment: 6 pages, 3 figures; published in the proceedings of the Neutrino Oscillation Workshop, 4-11 September 2016, Otranto, Ital

Extracting circadian clock information from a single time point assay

A working internal circadian clock allows a healthy organism to keep time in order to anticipate transitions between night and day, allowing the temporal optimisation and control of internal processes. The internal circadian clock is regulated by a set of core genes that form a tightly coupled oscillator system. These oscillators are autonomous and robust to noise, but can be slowly reset by external signals that are processed by the master clock in the brain. In this thesis we explore the robustness of a tightly coupled oscillator model of the circadian clock, and show that its deterministic and stochastic forms are both significantly robust to noise. Using a simple linear algebra approach to rhythmicity detection, we show that a small set of circadian clock genes are rhythmic and synchronised in mouse tissues, and rhythmic and synchronised in a group of human individuals. These sets of tightly regulated, robust oscillators, are genes that we use to de ne the expected behaviour of a healthy circadian clock. We use these “time fingerprints" to design a model, dubbed “Time-Teller", that can be used to tell the time from single time point samples of mouse or human transcriptome. The dysfunction of the molecular circadian clock is implicated in several major diseases and there is significant evidence that disrupted circadian rhythm is a hallmark of many cancers. Convincing results showing the dysfunction of the circadian clock in solid tumours is lacking due to the difficulties of studying circadian rhythms in tumours within living mammals. Instead of developing biological assays to study this, we take advantage of the design of Time-Teller, using its underlying features to build a metric, ϴ, that indicates dysfunction of the circadian clock. We use Time-Teller to explore the clock function of samples from existing, publicly available tumour transcriptome data. Although multiple algorithms have been published with the aims of “time-telling" using transcriptome data, none of them have been reported to be able to tell the times of single samples, or provide metrics of clock dysfunction in single samples. Time-Teller is presented in this thesis as an algorithm that both tells the time of a single time-point sample, and provides a measure of clock function for that sample. In a case study, we use the clock function metric, , as a retrospective prognostic marker for breast cancer using data from a completed clinical trial. ϴ is shown to correlate with many prognostic markers of breast cancer, and we show how could also be a predictive marker for treatment efficacy and patient survival

Gambling Treatment Diversion Court: First in Nevada

The first Gambling Treatment Diversion Court was established in Las Vegas, Nevada in fall of 2018 following more than 25 years of effort by passionately concerned non-profit Executives, therapists, lawyers and judges. This panel represents one leader from each of those areas, including Judge Cheryl Moss, the first judge to open the Gambling Treatment Diversion Court (GTDC), Dayvid Figler, the first attorney to successfully represent a gambling client and refer her to the GTDC, Carol O\u27Hare, Executive Director of the non-profit Nevada Council on Problem Gambler with 25+ years leadership and advocacy for problem gamblers, Sydney Smith, M.A., Clinical Director of RISE treatment center in Las Vegas and nationally- and state-certified gambling counselor, and Denise F. Quirk, M.A., Clinical Director of the Reno Problem Gambling Center and nationally- and Nevada-certified problem gambling counselor and instructor at the University of Nevada, Reno. The panel will share the development of gambling diversion treatment, legal challenges and victories, the process of the GTDC, case studies of individuals with Gambling Disorder who have endured and succeeded in the legal process, and discussion relevant to the impact of the gambling diversion process at all levels of evaluation, advocacy, treatment and support for gamblers and communities

Evaluation of aesthetic integration between composite restorations and natural tooth in NCCL: a case report

NCCL (non carious cervical lesion) is defined as irreversible loss of dental hard tissue that does not involve bacteria. It consists of erosion, attrition, abrasion and abfraction that rarely occur alone. Dentinal hypersensitivity is an early symptom of NCCL. Preventive measures and restorative treatment can avoid the progress of NCCL. This paper reports a case of NCCL treatment with aesthetic purpose. The aesthetic evaluation was made by means of spectrophotometry as a standardized method. Spectrophotometric measurements such as International Commission on Illumination (CIE-Commission Internationale de l’Eclaraige) CIE L* a* b* and ΔE between the sound enamel and resin restoration, provide all the information about the outcome of the aesthetic restorative treatment