17 research outputs found
Glycopeptide-functionalized gold nanoparticles for antibody induction against the tumor associated mucin-1 glycoprotein
No full textWe report the preparation of gold nanoparticle (AuNP)-based vaccine candidates against the tumor-associated form of the mucin-1 (MUC1) glycoprotein. Chimeric peptides, consisting of a glycopeptide sequence derived from MUC1 and the T-cell epitope P30 sequence were immobilized on PEGylated AuNPs and the ability to induce selective antibodies in vivo was investigated. After immunization, mice showed significant MHC-II mediated immune responses and their antisera recognized human MCF-7 breast cancer cells. Nanoparticles designed according to this report may become key players in the development of anticancer vaccines. (C) 2016 Elsevier Ltd. All rights reserved
DNA Framework-based Topological Aptamer for Differentiating Subtypes of Hepatocellular Carcinoma Cells
No full textDroplet Digital Enzyme-Linked Oligonucleotide Hybridization Assay for Absolute RNA Quantification
No full textQuantitative investigation of the poly-adenine DNA dissociation from the surface of gold nanoparticles
No full textMicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnostics
No full textSensitive detection of miRNA based on enzyme-propelled multiple photoinduced electron transfer strategy
No full textLateral flow nucleic acid biosensor for sensitive detection of microRNAs based on the dual amplification strategy of duplex-specific nuclease and hybridization chain reaction
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