GENETICALLY ENCODED IRON SENSOR CELL LINE: A MODEL FOR STUDYING FERROPTOSIS AND CELLULAR IRON METABOLISM

Cell death is a biological process that is essential in proper cellular homeostasis, development, and function. Malfunction of this system can lead to different diseases and cancers. Ferroptosis is a form of cell death that occurs as a result of the accumulation of lipid peroxides, that are dependent on intracellular levels of iron. Iron is essential to multiple metabolic processes in the cell, including the catalyzation of lipid peroxides. Thus, intracellular iron levels must be tightly regulated. Our goal is to create a cellular model to study and detect changes in intracellular iron levels. Through the use of a genetically encoded fluorescent iron sensor, we have generated a stable cell line that provides fluorescent readout on intracellular iron levels. This model can be used to screen for genes, small molecules, and drugs that affect and regulate intracellular iron levels. These findings can then be used to discover new regulators of ferroptosis, data that could be essential to the treatment of ferroptosis-linked diseases

Coherent and generalized intelligent states for infinite square well potential and nonlinear oscillators

This article is an illustration of the construction of coherent and generalized intelligent states which has been recently proposed by us for an arbitrary quantum system $[ 1]$. We treat the quantum system submitted to the infinite square well potential and the nonlinear oscillators. By means of the analytical representation of the coherent states \`{a} la Gazeau-Klauder and those \`{a} la Klauder-Perelomov, we derive the generalized intelligent states in analytical ways

Phase operators, temporally stable phase states, mutually unbiased bases and exactly solvable quantum systems

We introduce a one-parameter generalized oscillator algebra A(k) (that covers the case of the harmonic oscillator algebra) and discuss its finite- and infinite-dimensional representations according to the sign of the parameter k. We define an (Hamiltonian) operator associated with A(k) and examine the degeneracies of its spectrum. For the finite (when k < 0) and the infinite (when k > 0 or = 0) representations of A(k), we construct the associated phase operators and build temporally stable phase states as eigenstates of the phase operators. To overcome the difficulties related to the phase operator in the infinite-dimensional case and to avoid the degeneracy problem for the finite-dimensional case, we introduce a truncation procedure which generalizes the one used by Pegg and Barnett for the harmonic oscillator. This yields a truncated generalized oscillator algebra A(k,s), where s denotes the truncation order. We construct two types of temporally stable states for A(k,s) (as eigenstates of a phase operator and as eigenstates of a polynomial in the generators of A(k,s)). Two applications are considered in this article. The first concerns physical realizations of A(k) and A(k,s) in the context of one-dimensional quantum systems with finite (Morse system) or infinite (Poeschl-Teller system) discrete spectra. The second deals with mutually unbiased bases used in quantum information.Comment: Accepted for publication in Journal of Physics A: Mathematical and Theoretical as a pape

Contributions of M. Daoud, F. Gieres and M. Kibler to the "Concise Encyclopedia of Supersymmetry"

Théori

Offshore wind power integration to support weak grid voltage for industrial loads using VSC-HVDC transmission system

This paper investigates the integration of the offshore wind power plant into the grid using voltage source converter high-voltage direct current (VSC-HVDC). The paper proposes both offshore and onshore converter stations control to support voltage variation in grid. Heavy industrial loads result in a weak grid. In this paper, the effect on industrial loads by the grid strength is shown. Then the paper proposes a solution for the grid voltage support for industrial loads connected to weak grids. The results showed that the increase of grid voltage from 0.7 pu to 1 pu at full load condition that provides a continuous operation without any interruption. The system was modelled using MATLAB/Simulink package