78 research outputs found
Kinetics of the Polymorphic Transition in Isotactic Poly(1-butene) under Uniaxial Extension. New Insights From Designed Mechanical histories.
Full text linkAnalisi micromeccanica di un modello elementare di materiale composito conparticelle eterogenee
No full textMicromechanical analysis of a model of particulate composite materials with composite particles. Survey of craze initiation criteria
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A topological and geometrical outline for description and design of polymeric macromolecules with structure regularity
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Some physical properties of two homologous series of perfluoro-polyoxyalkylene oligomers
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Synthesis and pharmacological evaluation of poly(oxyethylene) derivatives of 4-isobutylphenyl-2-propionic acid (ibuprofen).
No full textThe synthesis of three oligomeric derivatives of 4-isobutylphenyl-2-propionic acid (ibuprofen), namely, the monoester of tetraethylene glycol (I) and the diesters of poly(oxyethylene) samples having molecular weights of 1000 (+/- 50) and 2000 (+/- 150) (II and III), has been performed via the imidazolide method. The antiinflammatory activity of I-III, and of equivalent amounts of free drug, was determined in the carrageenan-induced rat paw edema assay at different times after oral administration and found to be considerably prolonged in the case of the three derivatives. The lowest molecular weight derivative (I) also had an enhanced initial activity with regard to 4-isobutylphenyl-2-propionic acid. These results were confirmed by measuring the plasma levels of 4-isobutylphenyl-2-propionic acid in rats at different times after oral administratio
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