The moderating role of stigma in the relationship between depression and resilience: results of a cross-sectional study in university students

Background/objective: Depression is a growing concern in university students and resilience has shown to play a protective role. The impact of stigma is still under-explored, with reference to its moderating role between depression and resilience. The present study investigate such a relationship among Italian university students. Methods: A cross-sectional design was applied in a simple of 1,912 students to examine the interrelationships between depression (Patient Health Questionnaire-9), resilience (Nicholson McBride Resilience questionnaire), and stigma (Stigma-9). Correlation, predictor, and moderation analyses were applied in RStudio. Results: A negative correlation was found between depressive symptoms and resilience (r = −0.455, p < 0.001). A positive correlation was found between depressive symptoms and stigma (r = 0.207, p < 0.001). Lower levels of resilience and higher levels of stigma were significant predictors of depressive symptoms [F(df, n) = 190.8(3, 1884), p < 0.001, R2 = 0.236]. The moderation analysis showed a weakening of resilience protective effect against depression as stigma levels increase [F(df,n) = 186.7(3,1908), p < 0.001, R2 = 0.226]. Conclusion: Stigma influences the relationship between depression and resilience. Anti-stigma interventions and programs empowering resilience, should be implemented in university settings to protect students from depression

The moderating role of stigma in the relationship between depression and resilience: results of a cross-sectional study in university students.

Background/objective: Depression is a growing concern in university students and resilience has shown to play a protective role. The impact of stigma is still under-explored, with reference to its moderating role between depression and resilience. The present study investigate such a relationship among Italian university students. Methods: A cross-sectional design was applied in a simple of 1,912 students to examine the interrelationships between depression (Patient Health Questionnaire-9), resilience (Nicholson McBride Resilience questionnaire), and stigma (Stigma-9). Correlation, predictor, and moderation analyses were applied in RStudio. Results: A negative correlation was found between depressive symptoms and resilience (r = -0.455, p &lt; 0.001). A positive correlation was found between depressive symptoms and stigma (r = 0.207, p &lt; 0.001). Lower levels of resilience and higher levels of stigma were significant predictors of depressive symptoms [F-(df,F- n) = 190.8((3, 1884)), p &lt; 0.001, R-2 = 0.236]. The moderation analysis showed a weakening of resilience protective effect against depression as stigma levels increase [F-(df,F-n) = 186.7((3,1908)), p &lt; 0.001, R-2 = 0.226]. Conclusion: Stigma influences the relationship between depression and resilience. Anti-stigma interventions and programs empowering resilience, should be implemented in university settings to protect students from depression

Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes.

OBJECTIVE: Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medullary thyroid carcinoma (MTC) associated (MEN 2A and 2B) or not familial MTC (FMTC) with other endocrine neoplasia due to germline RET gene mutations. The prevalence of these rare genetic diseases and their corresponding RET mutations are unknown due to the small size of the study population. METHODS: We collected data on germline RET mutations of 250 families with hereditary MTC followed in 20 different Italian centres. RESULTS AND CONCLUSIONS: The most frequent RET amino acid substitution was Val804Met (19.6%) followed by Cys634Arg (13.6%). A total of 40 different germline RET mutations were present. Six families (2.4%) were negative for germline RET mutations. The comparison of the prevalence of RET germline mutations in the present study with those published by other European studies showed a higher prevalence of Val804Met and Ser891Ala mutations and a lower prevalence of Leu790Phe and Tyr791Phe (P<0.0001). A statistically significant higher prevalence of mutations affecting non-cysteine codons was also found (P<0.0001). Furthermore, the phenotype data collection showed an unexpected higher prevalence of FMTC (57.6%) with respect to other MEN 2 syndromes (34% MEN 2A and 6.8% of MEN 2B). In conclusion, we observed a statistically significant different pattern of RET mutations in Italian MEN 2 families with respect to other European studies and a higher prevalence of FMTC phenotype. The different ethnic origins of the patients and the particular attention given to analysing apparently sporadic MTC for RET germline mutations may explain these findings

From hysteria to somatic symptom disorders: Searching for a common psychopathological ground

After decades of manifold contributions aimed at defining hysteria, somatisation and conversion, such syndromes are still neglected and their nosographical definition is debated. The DSM and the ICD have undergone major changes, but their clinical utility with regards to these syndromes is still questionable. On the contrary, the Diagnostic Criteria for Psychosomatic Research represents a useful clinical instrument since it translates psychosocial variables derived from psychosomatic research into operational tools. The present paper offers an overview on the psychopathological description of syndromes such as alexithymia, hypochondriasis, health anxiety, thanatophobia, conversion symptoms, anniversary and reaction which are frequent in clinical practice, but often misdiagnosed due to their absence in the DSM and the ICD. In addition, the influence of culture and cultural changes on the modifications of psychopathological manifestations is described as a further possible source of misdiagnosing and underreporting. New psychopathologies (e.g., multiple chemical sensitivity, orthorexia/vigorexia) that resemble conversion and/or somatisation have been developed, but neither is included in nosography nor taught to clinicians. The aim of the present paper is thus to describe psychopathological manifestations of somatic symptoms and related disorders to help clinicians formulate their diagnosis on the presence of signs and symptoms that can be elicited during a clinical visit, rather than by way of exclusion of other organic or psychiatric disease only